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API-2

Product Name
API-2
CAS No.
35943-35-2
Chemical Name
API-2
Synonyms
TCN;IAP1;MIHC;MYHL;BBMI;API-2;BIRC3;RNF49;MYO1A;DFNA48
CBNumber
CB3270000
Molecular Formula
C13H16N6O4
Formula Weight
320.3
MOL File
35943-35-2.mol
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API-2 Property

Melting point:
207 °C (decomp)
Boiling point:
459.21°C (rough estimate)
Density 
1.2633 (rough estimate)
refractive index 
1.7000 (estimate)
storage temp. 
Store at RT
solubility 
DMSO: >10mg/mL
form 
powder
pka
12.35±0.70(Predicted)
color 
tan
InChIKey
HOGVTUZUJGHKPL-HTVVRFAVSA-N
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Safety

WGK Germany 
3
RTECS 
RY8455000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T3830
Product name
Triciribine hydrate
Purity
≥97% (HPLC)
Packaging
5mg
Price
$274
Updated
2024/03/01
Sigma-Aldrich
Product number
124038
Product name
InSolution? Akt Inhibitor V, Triciribine
Packaging
2mg
Price
$345
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB1303874
Product name
ANTI-MYO1A (CENTER S291) antibody produced in rabbit
Purity
IgG fraction of antiserum, buffered aqueous solution
Packaging
400μL
Price
$461
Updated
2023/01/07
Cayman Chemical
Product number
10010237
Product name
Triciribine
Purity
≥98%
Packaging
1mg
Price
$47
Updated
2024/03/01
Cayman Chemical
Product number
10010237
Product name
Triciribine
Purity
≥98%
Packaging
5mg
Price
$107
Updated
2024/03/01
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API-2 Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is also a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.

Uses

Triciribine hydrate has been used to study the effect of diethyldithiocarbamate (DDC) on matrix metalloproteinase-1 (MMP-1) in hepatic stellate cells1. It has also been used to analyze ADAM 10 activation by (-)-epigallocatechin-3-gallate (EGCG) in N2a cells overexpressing Swedish mutant APP (SweAPP N2a cells)2.

Definition

ChEBI: Triciribine is a nucleoside analogue in which the nucleobase portion is a 1,4,5,6,8-pentaazaacenaphthylene ring system substituted with an amino group at position 3, and a methyl group at position 5 and is bound to the beta-D-ribofuranosyl moiety by an N(1)-glycosidic linkage. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor.

Biological Activity

Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumors. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.

Biochem/physiol Actions

Triciribine is a highly selective Akt/PKB inhibitor, that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3.

storage

Store at RT

API-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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API-2 Suppliers

Canada 1 China 121 Germany 2 India 1 Switzerland 1 United Kingdom 4 United States 24 Global 154
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View Lastest Price from API-2 manufacturers

Wuhan Haorong Biotechnology Co.,Ltd
Product
API-2 / TRICIRIBINE 35943-35-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000
Release date
2023-08-07
Wuhan Nutra Biotechnology Co.,Ltd
Product
Triciribine hydrate;TCN 35943-35-2
Price
US $0.00-0.00/g
Min. Order
10g
Purity
98%+
Supply Ability
100kgs
Release date
2021-05-27
Wuhan Cell Pharmaceutical Co., Ltd
Product
API-2 35943-35-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2023-04-14

35943-35-2, API-2Related Search:

triciribine phosphate,Triciribine 5'-phosphate API API-2 4-Amino-7H-pyrrolo[2,3-d]pyrimidine API94-02UNLEADEDGASOLINEVAPOUR API`sIntermediate LUPRAGEN(R) API,N-(3-AMINOPROPYL)IMDAZOLE (JD API) Acenaphthene 7-DEAZA-2'-DEOXYADENOSINE TUBERCIDIN N-METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE Sulphate API broth,Sulphate API agar TRICIRIBINE,[3H] G1969-85001 API-TOF-REFERENCE MASS apoptosis inhibitor API5L1 ACTIVE PHARMACEUTICAL INGREDIENTS (API) MULTIPLIER PE-SCIEX API2000 SULPHATE REDUCING AGAR ACC. TO API

  • API-2
  • 6-AMINO-4-METHYL-8-(BETA-D-RIBOFURANOSYL)-4H,8H-PYRROLO[4,3,2-DE]PYRIMIDO[4,5-C]PYRIDAZINE
  • AKT/PKB SIGNALING INHIBITOR-2
  • AKT INHIBITOR V
  • 1,5-DIHYDRO-5-METHYL-1-BETA-D-RIBOFURANOSYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE
  • 1,4,5,6,8-pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-beta-d-ribofura
  • API-2 (Tricirbine)
  • TRICIRIBINE
  • NSC 154020
  • TCN
  • 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
  • (1,4,5,6,8-Pentaazaacenaphthylen-3-aMine,1,5-dihydro-5-Methyl-1-b-D-ribofuranosyl-)
  • 6-AMino-4-Methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyriMido[4,5-c]pyridazine
  • (2R,3R,4S,5R)-2-(3-aMino-5-Methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
  • VD-0002
  • 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine Triciribine
  • Triciribine 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
  • Inhibitor V
  • (1R,2S,3R,5R)-3-(3-Amino-5-methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxymethyl)c
  • InSolution? Akt Inhibitor V, Triciribine
  • Triciribine hydrate
  • ANTI-CIAP2 (BIRC3)(N-TERMINAL) antibody produced in rabbit
  • BIRC3
  • IAP1
  • MIHC
  • RNF49
  • ANTI-MYO1A (CENTER S291) antibody produced in rabbit
  • Brush border myosin I
  • MYHL
  • Myosin-Ia
  • Anti-MYO1A antibody produced in rabbit
  • BBMI
  • DFNA48
  • MYO1A
  • Anti-Dfna48
  • Anti-Myhl
  • Anti-Myosin ia
  • Triciribine, >=98%
  • CS-542
  • API-2; NSC 154020; TCN
  • CS-690
  • Triciribine, NSC 154020, TCN
  • InSolution Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem
  • 1,4,5,6,8-pentaazaacenaphthylene,3-amino-1,5-dihydro-5-methyl-1-beta-d-ribof
  • 3-amine
  • 3-amino-1,5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1,4,5,6,8-pentaazaacenap
  • 4,5,6,8-pentaazaacenaphthylen-5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1
  • hthylene
  • nosyl-
  • pentaazacentopthylene
  • uranosyl-
  • TRICYCLIC NUCLEOSIDE
  • Triciribine (NSC-154020)
  • Triciribine, 98%, a DNA synthesis inhibitor
  • Tricirbine
  • 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-β-D-ribofuranosyl-
  • API-2 USP/EP/BP
  • Triciribine 13CD3