DESMETHYL LOPERAMIDE

Product Name: DESMETHYL LOPERAMIDE
CAS No.: 66164-07-6
Chemical Name: DESMETHYL LOPERAMIDE
Synonyms: dLop;R 20905;DESMETHYL LOPERAMIDE;N-Desmethyl Loperamid;N-Desmethyl Loperamide;Desmethylloperamide D5;Desmethyl loperamide HCl;Loperamide-N-desmethyl 100 μg/mL in Acetonitrile;4-(4-Chlorophenyl)-4-hydroxy-N-methyl-a,a-diphenyl-1-piperidinebutanamide;4-(4-Chlorophenyl)-4-hydroxy-N-Methyl-α,α-diphenyl-1-piperidinebutanaMide
CBNumber: CB0462831
Molecular Formula: C28H31ClN2O2
Formula Weight: 463.01
MOL File: 66164-07-6.mol

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DESMETHYL LOPERAMIDE Property

Melting point:: 219-221?C
Boiling point:: 678.3±55.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMF: 2 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml
form: A crystalline solid
pka: 13.85±0.20(Predicted)

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Safety

HS Code: 9999999999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16126
Product name: N-Desmethyl-loperamide
Purity: ≥98%
Packaging: 500μg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 16126
Product name: N-Desmethyl-loperamide
Purity: ≥98%
Packaging: 1mg
Price: $330
Updated: 2024/03/01

Cayman Chemical

Product number: 16126
Product name: N-Desmethyl-loperamide
Purity: ≥98%
Packaging: 5mg
Price: $984
Updated: 2024/03/01

TRC

Product number: D291840
Product name: N-DesmethylLoperamide
Packaging: 2mg
Price: $365
Updated: 2021/12/16

Usbiological

Product number: 008596
Product name: N-Desmethyl Loperamide
Packaging: 1mg
Price: $475
Updated: 2021/12/16

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DESMETHYL LOPERAMIDE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A metabolite of Loperamide; a new and improved PET radiotracer for imaging P-gp function

Uses

Loperamide is an opiate which potently and selectively activates μ opioid receptors (Ki = 0.16 nM) exclusively in the periphery. N-Desmethyl-loperamide (dLop) is a major metabolite of loperamide. Like loperamide, dLop is a substrate of the ATP-dependent efflux transporter, P-glycoprotein. As a result, both the parent compound and the metabolite display restricted passage through the blood-brain barrier. dLop in biological samples can be analyzed by a variety of methods.

Definition

ChEBI: A monocarboxylic acid amide that is the methylamide of 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylbutanoic acid.

DESMETHYL LOPERAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DESMETHYL LOPERAMIDE Suppliers

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View Lastest Price from DESMETHYL LOPERAMIDE manufacturers

Zhejiang J&C Biological Technology Co.,Limited

Product: DESMETHYL LOPERAMIDE 66164-07-6
Price: US $0.00/gram
Min. Order: 1gram
Purity: 99%
Supply Ability: 10kg
Release date: 2022-02-17

66164-07-6, DESMETHYL LOPERAMIDERelated Search:

Levofloxacin hydrochloride Cisapride Norvoncomycin hydrochloride Loperamide hydrochloride Fluperamide DESMETHYL LOPERAMIDE Loperamide Loperamide

DESMETHYL LOPERAMIDE

4-(4-Chlorophenyl)-4-hydroxy-N-methyl-a,a-diphenyl-1-piperidinebutanamide

N-Desmethyl Loperamide

R 20905

Desmethyl loperamide HCl

Desmethylloperamide D5

4-(4-Chlorophenyl)-4-hydroxy-N-Methyl-α,α-diphenyl-1-piperidinebutanaMide

1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N-methyl-α,α-diphenyl-

dLop

N-Desmethyl Loperamid

4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-methyl-2,2-diphenylbutanamide

Loperamide-N-desmethyl 100 μg/mL in Acetonitrile

66164-07-6

C28H31ClN2O2HCl

C28H31ClN2O2

Amines

Heterocycles

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals