ChemicalBook > CAS DataBase List > 6-Methylpyridazin-3(2H)-one

6-Methylpyridazin-3(2H)-one

Product Name
6-Methylpyridazin-3(2H)-one
CAS No.
13327-27-0
Chemical Name
6-Methylpyridazin-3(2H)-one
Synonyms
6Me3OxoPyridaz;SPECS AC-907/25005370;6-Methyl-3-pyridazone;6-Methyl-3-pyridazinone;6-Methylpyridazin-3-one;3-pyridazinol, 6-methyl-;3-methyl-1H-pyridazin-6-one;6-METHYL-2H-PYRIDAZIN-3-ONE;6-METHYL-3(2H)-PYRIDAZINONE;6-METHYLPYRIDAZIN-3[2H]-ONE
CBNumber
CB0463313
Molecular Formula
C5H6N2O
Formula Weight
110.11
MOL File
13327-27-0.mol
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6-Methylpyridazin-3(2H)-one Property

Melting point:
143-145°C
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
11.51±0.40(Predicted)
form 
powder to crystal
color 
Light yellow to Amber to Dark green
BRN 
109928
InChI
InChI=1S/C5H6N2O/c1-4-2-3-5(8)7-6-4/h2-3H,1H3,(H,7,8)
InChIKey
QZWIXLPWMGHDDD-UHFFFAOYSA-N
SMILES
C1(=O)NN=C(C)C=C1
CAS DataBase Reference
13327-27-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
22-24/25-37-26
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2344
Product name
6-Methyl-3(2H)-pyridazinone
Purity
>98.0%(GC)
Packaging
1g
Price
$16
Updated
2023/06/20
TCI Chemical
Product number
M2344
Product name
6-Methyl-3(2H)-pyridazinone
Purity
>98.0%(GC)
Packaging
5g
Price
$48
Updated
2023/06/20
TRC
Product number
M327060
Product name
6-​Methyl-​3-​pyridazinone
Packaging
5g
Price
$140
Updated
2021/12/16
AK Scientific
Product number
X0304
Product name
6-Methylpyridazin-3(2H)-one
Packaging
5g
Price
$41
Updated
2021/12/16
Matrix Scientific
Product number
134775
Product name
6-Methyl-2,3-dihydropyridazin-3-one
Purity
95%+
Packaging
2.500g
Price
$215
Updated
2021/12/16
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6-Methylpyridazin-3(2H)-one Chemical Properties,Usage,Production

Uses

6-?Methyl-?3-?pyridazinone is a lignin-based dye used on wool. 6-?Methyl-?3-?pyridazinone is also used as a reactant for the synthesis of C-?(1-?aryl-?cyclohexyl)?-?methylamine derivatives as selective, orally available inhibitors of dipeptidyl peptidase IV, imidazopyridazinone derivatives as PDE7 inhibitors and pyridazinone derivatives with an arylpiperazinylalkyl chain as a potentent, orally active, antinociceptive agent.

Definition

ChEBI: 6-Methylpyridazin-3(2H)-one is a member of pyridazines.

Synthesis Reference(s)

Synthesis, p. 1158, 1994 DOI: 10.1055/s-1994-25663

Synthesis

5157-08-4

13327-27-0

General procedure for the synthesis of 6-methyl-3(2H)-pyridazinone from 4,5-dihydro-6-methylpyridazin-3(2H)-one: bromine (7.68 g, 48.05 mmol) was added slowly and dropwise to a solution of 6-methyl-4,5-dihydropyridazin-3(2H)-one (9.0 g, 80.26 mmol) in acetic acid (90 mL) at 90 °C. The reaction mixture was stirred continuously at 90 °C for 5-6 hours. Upon completion of the reaction, the excess acetic acid was removed by distillation under reduced pressure. The resulting residue was neutralized with aqueous sodium bicarbonate solution, followed by filtration to collect the solid product. The filter cake was dried to give the title compound 6-methyl-3(2H)-pyridazinone (6.0 g, 68% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 12.73 (s, 1H), 7.30 (d, J = 9.6 Hz, 1H), 6.80 (d, J = 9.9 Hz, 1H), 2.14 (s, 3H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 19, p. 6286 - 6291
[2] Journal of Chemical Research, Miniprint, 1995, # 8, p. 1840 - 1852
[3] Journal of the Chemical Society, 1947, p. 239,242
[4] Journal of the Chemical Society, 1947, p. 239,242
[5] Patent: US4595521, 1986, A

6-Methylpyridazin-3(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Methylpyridazin-3(2H)-one manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
6-Methylpyridazin-3(2H)-one 13327-27-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2025-03-10
Henan Aochuang Chemical Co.,Ltd.
Product
6-Methylpyridazin-3(2H)-one 13327-27-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-10
Shanghai Rlavie Technology Co ltd
Product
6-Methylpyridazin-3(2H)-one 13327-27-0
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%minHPLC
Supply Ability
100kgs/month
Release date
2021-11-10

13327-27-0, 6-Methylpyridazin-3(2H)-oneRelated Search:

Thioridazine Pyridaphenthion Hydralazine Sulfamethoxypyridazine 3(2H)-Pyridazinone SULFACHLOROPYRIDAZINE Sulfachloropyridazine sodium 6-Oxo-1,6-dihydro-pyridazine-3-carboxylicacid 4-METHYL-3(2H)-PYRIDAZINONE 6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone 5-Methyl-3(2H)-pyridazinone (R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone 6-Methylpyridazin-3(2H)-one 2-tert-Butyl-4,5-dichloro-3-2H-pyridazinone 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridainone(dl,d-,l-) METHYL 1-(2,4-DICHLOROPHENYL)-4-HYDROXY-6-OXO-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE 6-(2-THIENYL)-3(2H)-PYRIDAZINONE 5-ACETYL-4-AMINO-2,6-DIMETHYL-2,3-DIHYDROPYRIDAZIN-3-ONE

  • 6-Methyl-2,3-dihydropyridazine-3-one
  • 3-pyridazinol, 6-methyl-
  • 3-methyl-1H-pyridazin-6-one
  • 6-Methyl-2H-pyridazin-3-o...
  • 3-Hydroxy-6-methylpyridazine
  • 6-Methylpyridazine-3[2H]-one
  • 6-Methyl-1,2-dihydropyriMidin-2-one
  • 6-Methyl-3-pyridazinone
  • 6-Methyl-2H-pyridazine-3-one hydrobrMide salt
  • 4-ChlorothiobenzaMide, 97%, 97%
  • 6-Methyl-3(2H)-pyridazinone,98%
  • 6Me3OxoPyridaz
  • 6-Methyl-3(2<i>H</i>)-pyridazinone
  • SPECS AC-907/25005370
  • 6-METHYL-2H-PYRIDAZIN-3-ONE
  • 6-METHYL-3(2H)-PYRIDAZINONE
  • 6-METHYLPYRIDAZIN-3[2H]-ONE
  • 3(2H)-Pyridazinone,6-methyl-
  • 6-METHYL-2,3-DIHYDROPYRIDAZIN-3-ONE
  • 6-Methylpyridazin-3-one
  • 6-Methylpyridazin-32Hü-one, 98%
  • 6-Methyl-3-pyridazone
  • 3-Hydroxy-6-methylpyridazine 97%
  • 6-Methyl-3(2H)-pyridazinone&gt
  • 6-Methylpyridazin-3(2H)-one ISO 9001：2015 REACH
  • 6-Methyl-3-pyridazinone-98%
  • 6-methyl-3 (2H) - pyridazine ketone
  • 13327-27-0