4-METHYL-3(2H)-PYRIDAZINONE
- Product Name
- 4-METHYL-3(2H)-PYRIDAZINONE
- CAS No.
- 33471-40-8
- Chemical Name
- 4-METHYL-3(2H)-PYRIDAZINONE
- Synonyms
- 4-Methylpyridazin-3(2H);4-Methyl-pyridazin-3-ol;4-METHYL-3(2H)-PYRIDAZINONE;4-Methylpyridazin-3(2H)-one;4-Methylpyridazin-3(2H)-o...;3-HYDROXY-4-METHYLPYRIDAZINE;3(2H)-Pyridazinone, 4-methyl-;4-methyl-2,3-dihydropyridazin-3-one;4-METHYL-3(2H)-PYRIDAZINONE ISO 9001：2015 REACH;4-Methylpyridazin-3-ol, 3-Hydroxy-4-methyl-1,2-diazine
- CBNumber
- CB7848478
- Molecular Formula
- C5H6N2O
- Formula Weight
- 110.11
- MOL File
- 33471-40-8.mol
4-METHYL-3(2H)-PYRIDAZINONE Property
- Melting point:
- 158-159 °C
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.51±0.40(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- M327005
- Product name
- 4-Methyl-3(2H)-pyridazinone
- Packaging
- 1g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- 132053
- Product name
- 4-Methylpyridazin-3-ol
- Purity
- 97%
- Packaging
- 5g
- Price
- $1108
- Updated
- 2021/12/16
- Product number
- 66213
- Product name
- 4-Methyl-3(2H)-pyridazinone
- Packaging
- 1g
- Price
- $2200
- Updated
- 2021/12/16
- Product number
- 4H48-1-HS
- Product name
- 4-Methyl-2,3-dihydropyridazin-3-one
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $798
- Updated
- 2021/12/16
- Product number
- X0378
- Product name
- 4-Methyl-3(2H)-pyridazinone
- Packaging
- 250mg
- Price
- $136
- Updated
- 2021/12/16
4-METHYL-3(2H)-PYRIDAZINONE Chemical Properties,Usage,Production
Uses
4-Methyl-3(2H)-pyridazinone, is used as a building block for more complex compounds. It is also found within the structure of several pharmaceutical drugs. It can be used for the synthesis of a series of aminopyridazine derivatives of γ-aminobutyric acid acting as selective GABA-A antagonists.
Synthesis
105537-87-9
33471-40-8
The general procedure for the synthesis of 4-methyl-3(2H)-pyridazinone using 4-methyl-4,5-dihydropyridazin-3(2H)-one as a starting material was as follows: bromine (27.4 mL, 0.535 mol) was dissolved in glacial acetic acid (70 mL), and the solution was added slowly dropwise to 4-methyl-4,5-dihydropyridazin-3(2H)-one (25.8 g, 0.232 mol) dissolved in glacial acetic acid (330 mL), maintaining a temperature of about 50 °C during the reaction. After dropwise addition was completed, the reaction mixture was heated to 80 °C and maintained for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated to dryness under reduced pressure. The solid residue obtained was ground with ether and then the solid was dissolved in saturated sodium bicarbonate (NaHCO3) solution and extracted with ethyl acetate. The organic extracts were combined, dried with anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure to give a light brown solid product (12.2 g, 48% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 11.50 (1H, s), 7.71 (1H, d, J = 4.0 Hz), 7.10 (1H, d, J = 2.8 Hz), 2.23 (3H, d, J = 1.1 Hz) ppm.
References
[1] Patent: WO2004/74290, 2004, A1. Location in patent: Page 78-79
[2] Journal of Medicinal Chemistry, 1987, vol. 30, # 2, p. 239 - 249
4-METHYL-3(2H)-PYRIDAZINONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-METHYL-3(2H)-PYRIDAZINONE manufacturers
- Product
- 4-methyl-2,3-dihydropyridazin-3-one 33471-40-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 97%minHPLC
- Supply Ability
- 10kgs/month
- Release date
- 2021-11-15
- Product
- 4-METHYL-3(2H)-PYRIDAZINONE 33471-40-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-02
- Product
- 4-METHYL-3(2H)-PYRIDAZINONE 33471-40-8
- Price
- US $5.00/KG
- Min. Order
- 5KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-08-02