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4-METHYL-3(2H)-PYRIDAZINONE

Product Name
4-METHYL-3(2H)-PYRIDAZINONE
CAS No.
33471-40-8
Chemical Name
4-METHYL-3(2H)-PYRIDAZINONE
Synonyms
4-Methylpyridazin-3(2H);4-Methyl-pyridazin-3-ol;4-METHYL-3(2H)-PYRIDAZINONE;4-Methylpyridazin-3(2H)-one;4-Methylpyridazin-3(2H)-o...;3-HYDROXY-4-METHYLPYRIDAZINE;3(2H)-Pyridazinone, 4-methyl-;4-methyl-2,3-dihydropyridazin-3-one;4-METHYL-3(2H)-PYRIDAZINONE ISO 9001：2015 REACH;4-Methylpyridazin-3-ol, 3-Hydroxy-4-methyl-1,2-diazine
CBNumber
CB7848478
Molecular Formula
C5H6N2O
Formula Weight
110.11
MOL File
33471-40-8.mol
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4-METHYL-3(2H)-PYRIDAZINONE Property

Melting point:
158-159 °C
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
11.51±0.40(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
M327005
Product name
4-Methyl-3(2H)-pyridazinone
Packaging
1g
Price
$1320
Updated
2021/12/16
AK Scientific
Product number
X0378
Product name
4-Methyl-3(2H)-pyridazinone
Packaging
250mg
Price
$136
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-1-HS
Product name
4-Methyl-2,3-dihydropyridazin-3-one
Purity
97.0%
Packaging
250mg
Price
$290
Updated
2021/12/16
Matrix Scientific
Product number
132053
Product name
4-Methylpyridazin-3-ol
Purity
97%
Packaging
1g
Price
$396
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-1-HS
Product name
4-Methyl-2,3-dihydropyridazin-3-one
Purity
97.0%
Packaging
1g
Price
$798
Updated
2021/12/16
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4-METHYL-3(2H)-PYRIDAZINONE Chemical Properties,Usage,Production

Uses

4-Methyl-3(2H)-pyridazinone, is used as a building block for more complex compounds. It is also found within the structure of several pharmaceutical drugs. It can be used for the synthesis of a series of aminopyridazine derivatives of γ-aminobutyric acid acting as selective GABA-A antagonists.

Synthesis

105537-87-9

33471-40-8

The general procedure for the synthesis of 4-methyl-3(2H)-pyridazinone using 4-methyl-4,5-dihydropyridazin-3(2H)-one as a starting material was as follows: bromine (27.4 mL, 0.535 mol) was dissolved in glacial acetic acid (70 mL), and the solution was added slowly dropwise to 4-methyl-4,5-dihydropyridazin-3(2H)-one (25.8 g, 0.232 mol) dissolved in glacial acetic acid (330 mL), maintaining a temperature of about 50 °C during the reaction. After dropwise addition was completed, the reaction mixture was heated to 80 °C and maintained for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated to dryness under reduced pressure. The solid residue obtained was ground with ether and then the solid was dissolved in saturated sodium bicarbonate (NaHCO3) solution and extracted with ethyl acetate. The organic extracts were combined, dried with anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure to give a light brown solid product (12.2 g, 48% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 11.50 (1H, s), 7.71 (1H, d, J = 4.0 Hz), 7.10 (1H, d, J = 2.8 Hz), 2.23 (3H, d, J = 1.1 Hz) ppm.

References

[1] Patent: WO2004/74290, 2004, A1. Location in patent: Page 78-79
[2] Journal of Medicinal Chemistry, 1987, vol. 30, # 2, p. 239 - 249

4-METHYL-3(2H)-PYRIDAZINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHYL-3(2H)-PYRIDAZINONE Suppliers

China 96 Germany 2 India 1 United Kingdom 1 United States 12 Global 112
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
Porphyrin Systems
Tel
--
Fax
--
Email
hombrecher@porphyrin-systems.de
Country
Germany
ProdList
444
Advantage
50
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View Lastest Price from 4-METHYL-3(2H)-PYRIDAZINONE manufacturers

Shanghai Rlavie Technology Co ltd
Product
4-methyl-2,3-dihydropyridazin-3-one 33471-40-8
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
97%minHPLC
Supply Ability
10kgs/month
Release date
2021-11-15
Dideu Industries Group Limited
Product
4-METHYL-3(2H)-PYRIDAZINONE 33471-40-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-11-02
Career Henan Chemical Co
Product
4-METHYL-3(2H)-PYRIDAZINONE 33471-40-8
Price
US $5.00/KG
Min. Order
5KG
Purity
99%
Supply Ability
1ton
Release date
2019-08-02

33471-40-8, 4-METHYL-3(2H)-PYRIDAZINONERelated Search:

Cetohexazine (2E)-3-[4-(METHYLSULFONYL)PHENYL]PROPENOIC ACID 3,6-Dihydroxy-4-methylpyridazine 4-METHYL-3(2H)-PYRIDAZINONE 3,6-Dihydroxy-4,5-dimethylpyridazine 3(2H)-Pyridazinone 4-Methylpyridazine 6-PHENYL-3(2H)-PYRIDAZINONE-4-CARBOXYLIC ACID ETHYL ESTER METHYL 5-CYANO-1-(4-FLUOROPHENYL)-4-METHYL-6-OXO-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE Ridaflone 3-HYDROXY-6-(PYRROL-2-YL)-4-(TRIFLUOROMETHYL)PYRIDAZINE CBI-BB ZERO/005459 6-(BENZO-[B]-FURAN-2-YL)-3-HYDROXY-4-(TRIFLUOROMETHYL)PYRIDAZINE 4-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5,6-DIMETHYL-3-PYRIDAZINOL 3-(4-FLUOROPHENOXY)-6-PHENYL-4-PYRIDAZINECARBONITRILE BUTTPARK 126\40-63 ETHYL 3-PHENOXY-6-PHENYL-4-PYRIDAZINECARBOXYLATE 3-(4-CHLOROPHENOXY)-6-PHENYL-4-PYRIDAZINECARBONITRILE

  • 3-HYDROXY-4-METHYLPYRIDAZINE
  • 4-methyl-2,3-dihydropyridazin-3-one
  • 4-METHYL-3(2H)-PYRIDAZINONE
  • 4-Methyl-pyridazin-3-ol
  • 4-Methylpyridazin-3(2H)-one
  • 4-Methylpyridazin-3(2H)-o...
  • 4-Methylpyridazin-3-ol, 3-Hydroxy-4-methyl-1,2-diazine
  • 4-Methylpyridazin-3(2H)
  • 4-Methyl-2H-pyridazin-3-one 3-hydroxy-4-methylpyridazine
  • 3(2H)-Pyridazinone, 4-methyl-
  • 4-METHYL-3(2H)-PYRIDAZINONE ISO 9001：2015 REACH
  • 33471-40-8