ChemicalBook > CAS DataBase List > IITZ-01

IITZ-01

Product Name
IITZ-01
CAS No.
1807988-47-1
Chemical Name
IITZ-01
Synonyms
IITZ-01;CS-2857;Autophagy inhibitor IITZ-01;AUTOPHAGY INHIBITOR;IITZ 01;IITZ01;AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01;Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K;N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine;1,3,5-Triazine-2,4-diamine, N2-[4-(1H-benzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-
CBNumber
CB04668033
Molecular Formula
C26H23FN8O
Formula Weight
482.51
MOL File
1807988-47-1.mol
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IITZ-01 Property

Boiling point:
747.0±70.0 °C(Predicted)
Density 
1.420±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO:100.0(Max Conc. mg/mL);207.24(Max Conc. mM)
pka
11.55±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0067546
Product name
IITZ-01
Purity
99.80%
Packaging
5mg
Price
$120
Updated
2021/12/16
AK Scientific
Product number
8048EL
Product name
4-N-[4-(1H-Benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine
Packaging
5mg
Price
$162
Updated
2021/12/16
ChemScene
Product number
CS-0067546
Product name
IITZ-01
Purity
99.80%
Packaging
10mg
Price
$210
Updated
2021/12/16
ChemScene
Product number
CS-0067546
Product name
IITZ-01
Purity
99.80%
Packaging
25mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-0067546
Product name
IITZ-01
Purity
99.80%
Packaging
50mg
Price
$680
Updated
2021/12/16
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IITZ-01 Chemical Properties,Usage,Production

Biological Activity

IITZ-01 is a potent lysosomal autophagy inhibitor with antitumor activity, with IC50 value of 2.62 μM for PI3Kγ.

in vivo

IITZ-01 (45 mg/kg, ip every alternate day for 4 weeks) inhibits average breast tumor growth when compared with control from third day of treatment in triple-negative breast tumor models in mice.

Animal Model: MDA-MB-231 (TNBC)/green fluorescent protein (GFP) orthotropic breast cancer xenografts were developed in CrTac:NCr- Foxn nu BALB/c female nude mice.
Dosage: 45 mg/kg.
Administration: Intraperitoneal every alternate day for 4 weeks.
Result: Inhibited average breast tumor growth when compared with control from third day of treatment.

target

PI3Kγ

2.62 μM (IC 50 )

Autophagy

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IITZ-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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IITZ-01 Suppliers

China 50 India 1 United States 5 Global 56
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4121
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
993
Advantage
55
Shanghai Send Pharmaceutical Technology Co., Ltd.
Tel
021-50266790 Q3382968513
Fax
QQ3382968513
Email
Hailey@shsendpharm.com
Country
China
ProdList
3161
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8003
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2982
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
Country
China
ProdList
9737
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
7565
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29797
Advantage
68
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12308
Advantage
58

1807988-47-1, IITZ-01Related Search:


  • IITZ-01
  • AUTOPHAGY INHIBITOR;IITZ 01;IITZ01
  • Autophagy inhibitor IITZ-01
  • AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01
  • CS-2857
  • 1,3,5-Triazine-2,4-diamine, N2-[4-(1H-benzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-
  • N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine
  • Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K
  • 1807988-47-1
  • C26H23FN8O
  • API