ChemicalBook > CAS DataBase List > IITZ-01

IITZ-01

Product Name
IITZ-01
CAS No.
1807988-47-1
Chemical Name
IITZ-01
Synonyms
IITZ-01;CS-2857;IITZ-01 ，S8764;IITZ-01, 10 mM in DMSO;Autophagy inhibitor IITZ-01;AUTOPHAGY INHIBITOR;IITZ 01;IITZ01;AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01;Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K;N2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine;N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine
CBNumber
CB04668033
Molecular Formula
C26H23FN8O
Formula Weight
482.51
MOL File
1807988-47-1.mol
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IITZ-01 Property

Boiling point:
747.0±70.0 °C(Predicted)
Density 
1.420±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO:100.0(Max Conc. mg/mL);207.24(Max Conc. mM)
pka
11.55±0.10(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0067546
Product name
IITZ-01
Purity
99.80%
Packaging
5mg
Price
$120
Updated
2021/12/16
AK Scientific
Product number
8048EL
Product name
4-N-[4-(1H-Benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine
Packaging
5mg
Price
$162
Updated
2021/12/16
ChemScene
Product number
CS-0067546
Product name
IITZ-01
Purity
99.80%
Packaging
10mg
Price
$210
Updated
2021/12/16
ChemScene
Product number
CS-0067546
Product name
IITZ-01
Purity
99.80%
Packaging
25mg
Price
$420
Updated
2021/12/16
ChemScene
Product number
CS-0067546
Product name
IITZ-01
Purity
99.80%
Packaging
50mg
Price
$680
Updated
2021/12/16
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IITZ-01 Chemical Properties,Usage,Production

Uses

IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ.

Biological Activity

IITZ-01 is a potent lysosomal autophagy inhibitor with antitumor activity, with IC50 value of 2.62 μM for PI3Kγ.

in vivo

IITZ-01 (45 mg/kg, ip every alternate day for 4 weeks) inhibits average breast tumor growth when compared with control from third day of treatment in triple-negative breast tumor models in mice.

Animal Model: MDA-MB-231 (TNBC)/green fluorescent protein (GFP) orthotropic breast cancer xenografts were developed in CrTac:NCr- Foxn nu BALB/c female nude mice.
Dosage: 45 mg/kg.
Administration: Intraperitoneal every alternate day for 4 weeks.
Result: Inhibited average breast tumor growth when compared with control from third day of treatment.

target

PI3Kγ

2.62 μM (IC 50 )

Autophagy

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IC 50

PI3Kγ: 2.62 μM (IC50); Autophagy

References

[1] Guntuku L, et al. IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. Oncogene. 2018 Aug 30. DOI:10.1038/s41388-018-0446-2

IITZ-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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IITZ-01 Suppliers

China 71 India 1 United States 7 Global 79
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Abcam Limited
Tel
--
Fax
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Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1807988-47-1, IITZ-01Related Search:


  • IITZ-01
  • AUTOPHAGY INHIBITOR;IITZ 01;IITZ01
  • Autophagy inhibitor IITZ-01
  • AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01
  • CS-2857
  • 1,3,5-Triazine-2,4-diamine, N2-[4-(1H-benzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-
  • N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine
  • Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K
  • N2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine
  • IITZ-01, 10 mM in DMSO
  • IITZ-01 ，S8764
  • 1807988-47-1
  • C26H23FN8O
  • API