ChemicalBook > CAS DataBase List > 7-CHLORO-4-QUINAZOLINOL

7-CHLORO-4-QUINAZOLINOL

Product Name
7-CHLORO-4-QUINAZOLINOL
CAS No.
31374-18-2
Chemical Name
7-CHLORO-4-QUINAZOLINOL
Synonyms
Compound Fr12428;7-CHLORO-4-QUINAZOLINOL;7-CHLOROQUINAZOLIN-4-OL;7-Chloroquinazolin-4-one;7-Chloro-4(3H)-quinazolone;7-Chloro-3H-quizolin-4-one;7-CHOROQUINAZOLIN-4(3H)-ONE;7-Chloroquinazolin-4(1H)-one;7-chloro-1H-quinazolin-4-one;7-Chloroquinazolin-4(3H)-one
CBNumber
CB0470643
Molecular Formula
C8H5ClN2O
Formula Weight
180.59
MOL File
31374-18-2.mol
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7-CHLORO-4-QUINAZOLINOL Property

Melting point:
251-253 °C
Boiling point:
331.7±44.0 °C(Predicted)
Density 
1.50±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
0.36±0.20(Predicted)
Appearance
Off-white to light brown Solid
InChI
InChI=1S/C8H5ClN2O/c9-5-1-2-6-7(3-5)10-4-11-8(6)12/h1-4H,(H,10,11,12)
InChIKey
PMLONMIODRHERC-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC(Cl)=C2)C(=O)NC=1
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3720
Product name
7-Chloroquinazolin-4(1H)-one
Purity
min. 98.0 %
Packaging
1G
Price
$40
Updated
2025/07/31
TCI Chemical
Product number
C3720
Product name
7-Chloroquinazolin-4(1H)-one
Purity
min. 98.0 %
Packaging
5G
Price
$121
Updated
2025/07/31
TRC
Product number
C381203
Product name
7-Chloro-4-hydroxyquinazoline
Packaging
50mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
073870
Product name
7-Chloro-4-hydroxyquinazoline
Purity
95+%
Packaging
1g
Price
$15
Updated
2021/12/16
Matrix Scientific
Product number
073870
Product name
7-Chloro-4-hydroxyquinazoline
Purity
95+%
Packaging
5g
Price
$44
Updated
2021/12/16
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7-CHLORO-4-QUINAZOLINOL Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1305, 1946 DOI: 10.1021/ja01211a058

Synthesis

3473-63-0

89-77-0

31374-18-2

The general procedure for the synthesis of 7-chloro-4(3H)-quinazolinone from formamidine acetate and 2-amino-4-chlorobenzoic acid was as follows: 10 g of 2-amino-4-chlorobenzoic acid (BB1) and 8 g of formamidine acetate (1.3 eq.) were added to a 100 ml eggplant flask and mixed thoroughly. The mixture was placed in a microwave reactor and reacted at 60% power for 4 min. After completion of the reaction, it was cooled to room temperature, 30 ml of water was added, stirred and the solid product was collected by filtration. The resulting product was 7-chloro-4(3H)-quinazolinone (BB2) in a yield of 10 g with 95% yield.

References

[1] Patent: CN103570738, 2016, B. Location in patent: Paragraph 0303; 0304; 0306
[2] Patent: CN103382182, 2016, B. Location in patent: Paragraph 0272-0275
[3] Patent: WO2012/88712, 2012, A1. Location in patent: Page/Page column 16
[4] MedChemComm, 2015, vol. 6, # 1, p. 222 - 229

7-CHLORO-4-QUINAZOLINOL Preparation Products And Raw materials

Raw materials

Preparation Products

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7-CHLORO-4-QUINAZOLINOL Suppliers

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View Lastest Price from 7-CHLORO-4-QUINAZOLINOL manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
7-CHLORO-4-QUINAZOLINOL 31374-18-2
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-20
Career Henan Chemical Co
Product
7-CHLORO-4-QUINAZOLINOL 31374-18-2
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2018-07-31

31374-18-2, 7-CHLORO-4-QUINAZOLINOLRelated Search:

7-CHLORO-3,4-DIHYDROQUINAZOLIN-4-ONE 7-CHLORO-4-QUINAZOLINOL 7-chloroquinazoline-2,4(1H,3H)-dione 5-Chloro-3H-quinazolin-4-one 6-Chloro-4-hydroxyquinazoline 7-Bromo-6-chloro-4-quinazolinone 4-Hydroxyquinazoline 6-Nitro-7-Chloro-4-HydroxyQuinazoline 6-BROMO-7-CHLOROQUINAZOLIN-4-OL 7-CHLORO-2-METHYL-1H-QUINAZOLIN-4-ONE 7-CHLORO-2-METHYL-3-(5-METHYL-2-PYRIDINYL)-4(3H)-QUINAZOLINONE 7-CHLORO-2-METHYL-3-(1H-1,2,4-TRIAZOL-3-YL)-4(3H)-QUINAZOLINONE 3-(1H-1,3-BENZIMIDAZOL-2-YL)-7-CHLORO-2-METHYL-4(3H)-QUINAZOLINONE 7-CHLORO-3-(2,4-DICHLORO-5-METHOXYPHENYL)-2-SULFANYL-4(3H)-QUINAZOLINONE 7-CHLORO-2-METHYL-3-(1,3-THIAZOL-2-YL)-4(3H)-QUINAZOLINONE 7-CHLORO-2-METHYL-3-(1,3,4-THIADIAZOL-2-YL)-4(3H)-QUINAZOLINONE 2,7-DICHLOROQUINAZOLIN-4-OL 7-CHLORO-3-(2,4-DICHLORO-5-ISOPROPOXYPHENYL)-2-(METHYLSULFANYL)-4(3H)-QUINAZOLINONE

  • 7-CHLOROQUINAZOLIN-4-OL
  • 7-CHLORO-4(1H)-QUINAZOLINONE
  • 7-CHLORO-4-QUINAZOLINOL
  • 7-CHLORO-4-HYDROXYQUINAZOLINE
  • 7-Chloro-4(3H)-quinazolone
  • 7-Chloroquinazolin-4(3H)-one
  • 7-Chloroquinazolin-4-one
  • 7-chloro-1H-quinazolin-4-one
  • 4(3H)-Quinazolinone, 7-chloro-
  • 7-Chloroquinazolin-4(1H)-one
  • 7-Chloro-4(3H-quinazolin-4-one
  • 7-Chloro-3<i>H</i>-quinazolin-4-one
  • 7-chloro-4(3H)-quinazolinone
  • 7-CHLORO-4-QUINAZOLINOL###31374-18-2
  • 7-Chloro-4-Hydroxyquinazoline(WX636185)
  • 7-Chloro-3H-quizolin-4-one
  • 7-chloro-1,4-dihydroquinazolin-4-one
  • 7-CHOROQUINAZOLIN-4(3H)-ONE
  • Cyclopropanamine,1-ethyl-,hydrochloride(1:5)
  • Benzenesulfonylchloride,9-ethoxy-
  • Compound Fr12428
  • 31374-18-2
  • 128517-87-2
  • Alcohols and Derivatives
  • Heterocycles