6-Chloro-4-hydroxyquinazoline

Product Name: 6-Chloro-4-hydroxyquinazoline
CAS No.: 16064-14-5
Chemical Name: 6-Chloro-4-hydroxyquinazoline
Synonyms: 6-chloroquinazolin-4(1H)-one;6-CHLOROQUINAZOLIN-4(3H)-ONE;6-CHLORO-4-QUINAZOLONE;6-CHLOROQUINAZOLIN-4-OL;6-CHLORO-4-QUINAZOLINONE;6-chloro-4(3h)-quinazolinon;6-chlro-4-hydroxyquinazoline;6-CHLORO-3H-QUINAZOLIN-4-ONE;6-CHLORO-4(3H)-QUINAZOLINONE;6-CHLORO-4-HYDROXYQUINAZOLINE
CBNumber: CB3137947
Molecular Formula: C8H5ClN2O
Formula Weight: 180.59
MOL File: 16064-14-5.mol

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6-Chloro-4-hydroxyquinazoline Property

Melting point:: 263-265 °C
Boiling point:: 128.9°C (rough estimate)
Density: 1.4300 (rough estimate)
refractive index: 1.5430 (estimate)
storage temp.: Sealed in dry,Room Temperature
pka: 0.93±0.20(Predicted)
Appearance: Off-white to light brown Solid

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R745979
Product name: 6-CHLORO-4(3H)-QUINAZOLINONE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $113
Updated: 2025/07/31

Sigma-Aldrich

Product number: R745979
Product name: 6-CHLORO-4(3H)-QUINAZOLINONE
Purity: AldrichCPR
Packaging: 25MG
Price: $106
Updated: 2023/06/20

TRC

Product number: C429308
Product name: 6-Chloroquinazolin-4-ol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C429308
Product name: 6-Chloroquinazolin-4-ol
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: C429308
Product name: 6-Chloroquinazolin-4-ol
Packaging: 500mg
Price: $90
Updated: 2021/12/16

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6-Chloro-4-hydroxyquinazoline Chemical Properties,Usage,Production

Synthesis

77287-34-4

5202-85-7

16064-14-5

Yb(OTf)3 (0.20 mmol, 5.0 mol%) and homotrimethylbenzene (5.0 mL) were added to a 20 mL Pyrex flask equipped with a magnetic stirring bar and a reflux condenser under argon protection, using 2-amino-5-chlorobenzamide (1, 4.0 mmol) and formamide (2, 6.0 mmol). The reaction mixture was stirred at 120-165 °C (bath temperature) for 6 hours. After completion of the reaction, the mixture was cooled to room temperature and analyzed by GLC, GC-MS (EI) and LC-MS (ESI). After removal of homotrimethylbenzene by evaporation under vacuum, the product 6-chloroquinazolin-4-one (3) was separated by recrystallization from MeOH/hexanes and/or silica gel medium pressure column chromatography (eluent: EtOAc/hexanes = 50/50 to 100% EtOAc. for 3j, eluent: MeOH/CHCl3 = 50/50). The structures of the products were confirmed by 1H NMR (400 MHz, DMSO-d6) and 13C NMR (100 MHz, DMSO-d6) spectra. The analytical and spectral data of compounds 3a-e, 3f, 3g, 3h and 3j were in agreement with literature reports. The characterization data of product 3i are given below.

References

[1] Heterocycles, 2015, vol. 90, # 2, p. 857 - 865

6-Chloro-4-hydroxyquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-4-hydroxyquinazoline Suppliers

China 90 Germany 3 India 2 United Kingdom 3 United States 17 Global 115

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View Lastest Price from 6-Chloro-4-hydroxyquinazoline manufacturers

Career Henan Chemical Co

Product: 6-Chloro-4-hydroxyquinazoline 16064-14-5
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

16064-14-5, 6-Chloro-4-hydroxyquinazolineRelated Search:

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6-chloro-4(3h)-quinazolinon

6-CHLOROQUINAZOLIN-4(3H)-ONE

6-CHLOROQUINAZOLIN-4-OL

6-CHLORO-4-HYDROXYQUINAZOLINE

6-CHLORO-3H-QUINAZOLIN-4-ONE

6-CHLORO-4-QUINAZOLINONE

6-CHLORO-4-QUINAZOLONE

6-Chloroquinazolin-4-ol, 6-Chloro-4-hydroxyquinazoline

6-Chloroquinazolin-4(3H)-one 98%

6-chlro-4-hydroxyquinazoline

6-Chloro-3-hydroquinazolin-4-one

6-Chloro-3,4-dihydroquinazoline-4-one

6-chloroquinazolin-4(1H)-one

4(3H)-Quinazolinone, 6-chloro-

6-Chloro-4-hydroxyquinazoline ISO 9001：2015 REACH

6-CHLORO-4(3H)-QUINAZOLINONE

16064-14-5

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