ChemicalBook > CAS DataBase List > VU 0409106

VU 0409106

Product Name
VU 0409106
CAS No.
1276617-62-9
Chemical Name
VU 0409106
Synonyms
VU 0409106;3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide;Benzamide, 3-fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)-
CBNumber
CB04726384
Molecular Formula
C15H11FN4O2S
Formula Weight
330.34
MOL File
1276617-62-9.mol
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VU 0409106 Property

Density 
1.445±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
6.61±0.50(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
5322
Product name
VU0409106
Purity
≥98%(HPLC)
Packaging
10
Price
$164
Updated
2021/12/16
TRC
Product number
V787573
Product name
VU0409106
Packaging
100mg
Price
$1080
Updated
2021/12/16
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VU 0409106 Chemical Properties,Usage,Production

Uses

VU 0409106 is a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5). VU0409106 also was effective in a mouse marble burying anxiety behaviour.

in vivo

VU0409106 (10 mg/kg; i.p.; once) penetrates the blood-brain barrier (BBB) and demonstrates good brain to plasma ratio that near unity[1].

Animal Model:CD-1 mice[1]
Dosage:10 mg/kg (10% Tween 80 formulation)
Administration:Intraperitoneal injection.
Result:1.19Pharmacokinetic Parameters of VU0409106 in CD-1 mice[1].
IP (10 mg/kg)
Plasma Tmax (h)0.25
Plasma Cmax (ng/mL)1450
Brain Tmax (h)0.25
Brain Cmax (ng/mL)1350
AUCplasma (ng/mL?h)702
AUCbrain (ng/mL?h)696
B/P ratio0.99

IC 50

mGlu5: 24 nM (IC50)

VU 0409106 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU 0409106 Suppliers

China 4 India 1 Japan 1 United Kingdom 1 United States 4 USA 1 Global 12
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
996
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Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2966
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58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
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58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19699
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58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19881
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58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52924
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58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38630
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58

1276617-62-9, VU 0409106Related Search:

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  • VU 0409106
  • 3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide
  • Benzamide, 3-fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)-
  • 1276617-62-9