5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9α)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester

Product Name: 5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9α)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester
CAS No.: 1841134-72-2
Chemical Name: 5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9α)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester
Synonyms: BCN-exo-PEG3-NH2;exo BCN-PEG3-NH2;exo BCN-PEG3-amine;BCN-PEG3-AMINE (EXO);5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester
CBNumber: CB04809469
Molecular Formula: C19H32N2O5
Formula Weight: 368.47
MOL File: 1841134-72-2.mol

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5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9α)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester Property

Boiling point:: 519.6±40.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: Storage temp. -20°C
pka: 12.05±0.46(Predicted)
form: Liquid (Density: 1.14±0.1 g/cm3)
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9α)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester Chemical Properties,Usage,Production

Uses

BCN- exo- PEG3- NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. BCN- exo- PEG3- NH2 is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Biological Activity

BCN-exo-PEG3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC 50

PEGs

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9α)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9α)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester Suppliers

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Changzhou Hopschain Chemical Co.,Ltd.

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Xi'an Confluore Biological Technology Co., Ltd.

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View Lastest Price from 5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9α)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: exo BCN-PEG3-amine 1841134-72-2
Price: US $0.00/mg
Min. Order: 50mg
Purity: >95.00%
Supply Ability: 250mg
Release date: 2024-03-20

1841134-72-2, 5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9α)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl esterRelated Search:

BCN-OH endo-BCN-PEG4-acid - exo BCN-O-PNB endo BCN-O-PNB endo-BCN-PEG4-NHS ester (1R,8S,9r)-bicyclo[6.1.0]nonan-9-ylmethanol

BCN-PEG3-AMINE (EXO)

exo BCN-PEG3-NH2

BCN-exo-PEG3-NH2

exo BCN-PEG3-amine

5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester

1841134-72-2

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