exo BCN-O-PNB

Product Name: exo BCN-O-PNB
CAS No.: 1380006-72-3
Chemical Name: exo BCN-O-PNB
Synonyms: exo BCN-PNP;exo BCN-O-PNP;BCN-PNP (EXO);exo BCN-O-PNB;exo BCN - active ester (p-NPC);exo BCN - active ester (p-NPE);exo-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (4-Nitrophenyl) Carbonate;((1R,8S,9R)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl 4-nitrophenyl carbonate;rel-((1R,8S,9r)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (4-nitrophenyl) carbonate;Carbonic acid, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl 4-nitrophenyl ester
CBNumber: CB54665284
Molecular Formula: C17H17NO5
Formula Weight: 315.33
MOL File: 1380006-72-3.mol

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exo BCN-O-PNB Property

Boiling point:: 475.7±37.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
solubility: good in DMF, DMSO, acetonitrile
form: Solid
color: White to off-white
Appearance: off-white solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-20505
Product name: ((1R,8S,9r)-bicyclo[6.1.0]non-4-yn-9-yl)methyl4-nitrophenylcarbonate
Packaging: 100mg
Price: $430
Updated: 2021/12/16

BroadPharm

Product number: BP-20505
Product name: ((1R,8S,9r)-bicyclo[6.1.0]non-4-yn-9-yl)methyl4-nitrophenylcarbonate
Packaging: 500mg
Price: $1450
Updated: 2021/12/16

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exo BCN-O-PNB Chemical Properties,Usage,Production

Description

BCN-PNP carbonate is a tool to introduce BCN moety via carbamate linkage with primary amino groups of substrate. Reaction conditions is similar to NHS-amino linkage but PNP ester provides less off-target hydrolysis and higher conjugation yield forming hydrolytically stable bond with substrate.

Bicyclononyne (BCN) is one of the most reactive cyclooctynes for copper-free click chemistry. Both exo- and endo- isomers are active and have near the same power of reactions konstants [1,2]. BCN reacts even faster than DBCO [1] with aromatic azides and comparing to dibenzofused systems has two advantages. First, it contains a plane of symmetry which prevents the formation of mixtures of stereoisomeric products. Second, BCN provides lower lipophilicity which is typically more beneficial when reaction is performed in aqueous solutions. Unlike DBCO, BCN reactivity is not only limited to azides (SPAAC) and nitrones (SPANC), but also covers tetrazines (IEDDA) [2] and more recently tetrazoles (photoclick) [3] providing exceptional reaction rates.

Uses

exo BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. exo BCN-O-PNB is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

exo BCN-O-PNB Preparation Products And Raw materials

Raw materials

Preparation Products

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exo BCN-O-PNB Suppliers

China 24 United States 2 Global 26

Shanghai Jiyi Biological Technology Co., LTD

Tel: 021-54135696 18516235431
Fax: 50815371
Email: shgegenetech@163.com
Country: China
ProdList: 469
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
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ProdList: 10784
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Hangzhou Taorui Biotechnology Co., Ltd

Tel: 4000-360-990 15268198094
Email: sales@torreybio.com
Country: China
ProdList: 3806
Advantage: 58

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 0431-80514535 19917294565
Email: ET-market@chemextension.com
Country: China
ProdList: 4673
Advantage: 58

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View Lastest Price from exo BCN-O-PNB manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: exo BCN-O-PNB 1380006-72-3
Price: US $0.00/mg
Min. Order: 100mg
Purity: >95.00%
Supply Ability: 1g
Release date: 2024-03-20

1380006-72-3, exo BCN-O-PNBRelated Search:

BCN-OH endo-BCN-PEG4-acid - endo BCN-O-PNB endo-BCN-PEG4-NHS ester - (1R,8S,9r)-bicyclo[6.1.0]nonan-9-ylmethanol

exo BCN-O-PNB

BCN-PNP (EXO)

exo BCN-O-PNP

exo BCN - active ester (p-NPE)

exo BCN - active ester (p-NPC)

Carbonic acid, (1α,8α,9α)-bicyclo[6.1.0]non-4-yn-9-ylmethyl 4-nitrophenyl ester

((1R,8S,9R)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl 4-nitrophenyl carbonate

rel-((1R,8S,9r)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (4-nitrophenyl) carbonate

exo BCN-PNP

exo-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (4-Nitrophenyl) Carbonate

1380006-72-3

SiChem