5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester

Product Name: 5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester
CAS No.: 1883512-27-3
Chemical Name: 5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester
Synonyms: BCN-endo-PEG3-NH2;endo BCN-PEG3-NH2;endo-BCN-PEG3-amine;BCN-PEG3-AMINE (ENDO);5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-, (1α,8α,9β)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester
CBNumber: CB74809468
Molecular Formula: C19H32N2O5
Formula Weight: 368.47
MOL File: 1883512-27-3.mol

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5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester Property

Boiling point:: 519.6±40.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: -20°C, sealed storage, away from moisture and light
form: Oil
pka: 12.05±0.46(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24510
Product name: endo-BCN-PEG3-amine
Purity: 98%
Packaging: 100mg
Price: $350
Updated: 2021/12/16

BroadPharm

Product number: BP-24510
Product name: endo-BCN-PEG3-amine
Purity: 98%
Packaging: 250mg
Price: $650
Updated: 2021/12/16

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5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester Chemical Properties,Usage,Production

Description

endo-BCN-PEG3-amine is a click chemistry linker containing a BCN and an amine group. The BCN group can react with azide-tagged biomolecules under mile condition. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Uses

endo-BCN-PEG3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG3-NH2 is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester Suppliers

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Changzhou Hopschain Chemical Co.,Ltd.

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Zhengzhou convergence chemical co., LTD

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Beijing Jin Ming Biotechnology Co., Ltd.

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View Lastest Price from 5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: endo BCN-PEG3-amine 1883512-27-3
Price: US $0.00/mg
Min. Order: 50mg
Purity: >95.00%
Supply Ability: 250mg
Release date: 2024-03-20

1883512-27-3, 5,?8,?11-?Trioxa-?2-?azatridecanoic acid, 13-?amino-?, (1α,?8α,?9β)?-?bicyclo[6.1.0]?non-?4-?yn-?9-?ylmethyl esterRelated Search:

BCN-OH endo-BCN-PEG4-acid exo BCN-O-PNB endo BCN-O-PNB endo-BCN-PEG4-NHS ester - (1R,8S,9r)-bicyclo[6.1.0]nonan-9-ylmethanol

BCN-PEG3-AMINE (ENDO)

endo BCN-PEG3-NH2

BCN-endo-PEG3-NH2

endo-BCN-PEG3-amine

5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-, (1α,8α,9β)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester

1883512-27-3

SiChem