ChemicalBook > CAS DataBase List > N-Acetyl-L-proline

N-Acetyl-L-proline

Product Name
N-Acetyl-L-proline
CAS No.
68-95-1
Chemical Name
N-Acetyl-L-proline
Synonyms
AC-PRO-OH;NSC 280718;AC-PROLINE;N-AC-L-PRO;N-Ac-Pro-OH;Ac-L-Pro-Oh;N-Acetyl-Pro;AC-PYRD(2)-OH;Acetylproline;N-ACETYL-L-PRO
CBNumber
CB0481658
Molecular Formula
C7H11NO3
Formula Weight
157.17
MOL File
68-95-1.mol
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N-Acetyl-L-proline Property

Melting point:
115-117 °C
alpha 
-86 º (c=1 EtOH)
Boiling point:
366.2±35.0 °C(Predicted)
Density 
1.274±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
pka
3.69±0.20(Predicted)
form 
Powder
color 
White to off-white
BRN 
83200
InChI
InChI=1S/C7H11NO3/c1-5(9)8-4-2-3-6(8)7(10)11/h6H,2-4H2,1H3,(H,10,11)/t6-/m0/s1
InChIKey
GNMSLDIYJOSUSW-LURJTMIESA-N
SMILES
C(O)(=O)[C@@H]1CCCN1C(C)=O
CAS DataBase Reference
68-95-1(CAS DataBase Reference)
NIST Chemistry Reference
L-proline, 1-acetyl-(68-95-1)
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Safety

Hazard Codes 
Xi
Safety Statements 
24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A0783
Product name
N-Acetyl-L-proline
Packaging
1g
Price
$64.4
Updated
2024/03/01
Sigma-Aldrich
Product number
A0783
Product name
N-Acetyl-L-proline
Packaging
5g
Price
$140
Updated
2023/06/20
Alfa Aesar
Product number
L14300
Product name
N-Acetyl-L-proline, 99%
Packaging
1g
Price
$36.3
Updated
2023/06/20
Alfa Aesar
Product number
L14300
Product name
N-Acetyl-L-proline, 99%
Packaging
5g
Price
$106
Updated
2023/06/20
Usbiological
Product number
235177
Product name
Acetyl-L-proline 99+%
Packaging
5g
Price
$200
Updated
2021/12/16
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N-Acetyl-L-proline Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

N-Acetyl-L-proline is an aminoacid used in the synthesis of pharmaceutical compounds useful in preventing and treating disorders and syndromes associated with the nervous, vascular, musculoskeletal, o r cutaneous systems.

Definition

ChEBI: N-acetyl-L-proline is a N-acetyl-L-amino acid, a N-acylpyrrolidine, a pyrrolidinemonocarboxylic acid and a L-proline derivative.

Biochem/physiol Actions

N-acetyl-L-proline is an analog of the COOH-terminal dipeptide portion of preferred substrates of angiotensin-converting enzyme (ACE). It may be used in studies of the binding of substrates and inhibitors by ACE and to differentiate the specificities of various aminoacylases.

References

[1] Jingxuan Qiu. “Solubility Behavior and Polymorphism of N-Acetyl-l-proline in 16 Individual Solvents from 283.15 to 323.15 K.” Journal of Chemical & Engineering Data 66 3 (2021): 1533–1542.

Description

N-Acetyl-L-proline (NALP) is an N-acetyl derivative of L-proline, which has wide application in medicine and is commonly utilized as a biologically active supplement. It can also act as an intermediate for synthesizing pharmaceuticals for preventing and treating some disorders and syndromes associated with the nervous, vascular, musculoskeletal, or cutaneous systems. In laboratories, it could play the role of a simple model for the secondary structure of proline-containing peptides. NALP can be acetylated from L-proline via a standard method, in the environment of acetic acid, or by the action of acetic anhydride on aqueous solutions of the products of the alkaline hydrolysis of gelatin followed by extraction. However,  these methods may result in the production of many byproducts[1]. 

N-Acetyl-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Acetyl-L-proline Suppliers

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View Lastest Price from N-Acetyl-L-proline manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
N-Acetyl-L-proline 68-95-1
Price
US $45.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-27
WUHAN FORTUNA CHEMICAL CO., LTD
Product
N-Acetyl-L-proline 68-95-1
Price
US $1.00/g
Min. Order
100g
Purity
98%
Supply Ability
200kg/month
Release date
2021-06-09
Hebei Kingfiner Technology Development Co.Ltd
Product
N-Acetyl-L-proline 68-95-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
50000kg
Release date
2024-06-03

68-95-1, N-Acetyl-L-prolineRelated Search:

N-Acetyl-L-cysteine L-Proline cis-4-Hydroxy-L-proline Acetylacetone Acetyl chloride D-Proline L-PROLINE-(4-3H(N)) N-Acetyl-L-valine AC-TYR-NH2 N-ALPHA-ACETYL-D-PROLINE,N-ACETYL-D-PROLINE,ACETYL-D-PROLINE Fosinopril sodium 4β-Cyclohexyl-1-[[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline,(4S)-4-Cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-L-proline Disodium Salt Fosinopril N-ALPHA-ACETYL-L-PROLINE AMIDE,ACETYL-L-PROLINE AMIDE N6-Trifluoroacetyl-L-lysyl-L-proline 1-ACETYLPYRROLIDINE 1-[(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-proline tert-Butyl Ester,7-Methoxycoumarin-4-Acetyl-L-proline tert-Butyl Ester (4S)-4-Cyclohexyl-1-[2-[hydroxy(4-phenyl-d5-butyl)phosphinyl]acetyl]-L-proline Sodium Salt

  • N-AN-Acetyl-L-prolineN-Acetyl-L-prolinecetyl-L-proline
  • (2S)-1-acetyl-2-pyrrolidinecarboxylate
  • (S)-N-Acetylproline
  • L-N-Acetylproline
  • NSC 280718
  • N-Ac-Pro-OH
  • ASINEX-REAG BAS 16579166
  • ACETYL-L-PROLINE
  • AC-PYRD(2)-OH
  • AC-PROLINE
  • AC-PRO-OH
  • N-ALPHA-ACETYL-L-PROLINE
  • N-ALPHA-ACETYL-L-PYRROLIDINE-2-CARBOXYLIC ACID
  • N-ACETYL-L-PRO
  • N-ACETYL-L-PROLINE
  • N-AC-L-PRO
  • (S)-1-ACETYL-PYRROLIDINE-2-CARBOXYLIC ACID
  • 1-Acetylproline
  • Acetylproline
  • L-Proline, 1-acetyl-
  • Proline, 1-acetyl-, L-
  • 1-acetyl-L-proline
  • Ac-L-Pro-Oh
  • L-Proline, 1-acetyl- (9CI)
  • (S)-Acetyl-pyrrolidine-2-carboxylic acid
  • Acetyl-L-proline99%
  • N-ACETYL-L-PROLINE (N-AC-L-PRO)
  • N-alpha-Actetyl-L-proline
  • N-Acethyl-L-proline
  • (+/-)-(3-Methoxy-4-hydroxyphenyl)-2-isopropylaminoethanol hydrochloride
  • Benzenemethanol, 4-hydroxy-3-methoxy-a-[[(1-methylethyl)amino]methyl]-, hydrochloride
  • Vanillyl alcohol, a-[(isopropylamino)methyl]-, hydrochloride
  • (2S)-1-Acetylpyrrolidine-2α-carboxylic acid
  • N-Acetyl-L-proline,99%
  • N-ACETYL-L-PROLINE (USP)
  • Ac-Pro-OH ,≥99%
  • (S)-(-)-N-Acetylproline
  • N-Acetyl-L-proline, 99% 1GR
  • l-proline n-acetyl
  • N-Acetyl-L-proline USP/EP/BP
  • N-Acetyl-L-Proline extrapure, 98%
  • N-Acetyl-Pro
  • 68-95-1
  • C7H10NO3
  • CARBOXYLIC ACID
  • Modified Amino Acids
  • Biochemicals and Reagents
  • BioChemical
  • A - H
  • Amino Acids and Peptides
  • A - H
  • Amino Acids
  • Modified Amino Acids
  • Amino Acid Derivatives
  • Amino Acids
  • chiral
  • N-Acetyl-Amino acid series
  • amino