ChemicalBook > CAS DataBase List > 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide

Product Name
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
CAS No.
72811-73-5
Chemical Name
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
Synonyms
BM 960102;Torsemide Imp B;TORSEMIDE EP IMP B;4-(3'-Methylphenyl)a;TorseMide IMpurity B;SPECS AJ-333/25006115;Torasemide intermediate;Torsemide EP Impurity B;Torasemide EP Impurity B;Torasemide impurity B (EP)
CBNumber
CB0486466
Molecular Formula
C12H13N3O2S
Formula Weight
263.32
MOL File
72811-73-5.mol
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4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Property

Melting point:
162-164?C
Boiling point:
475.8±55.0 °C(Predicted)
Density 
1.357±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
9.53±0.60(Predicted)
color 
White to Off-White
BRN 
5438165
InChIKey
ZXPCUGWAKUIOOF-UHFFFAOYSA-N
CAS DataBase Reference
72811-73-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
HS Code 
2935909550
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1672315
Product name
Torsemide Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
75mg
Price
$1630
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR3145
Product name
Torsemide Related Compound A
Purity
pharmaceutical secondary standard, certified reference material
Packaging
150MG
Price
$466
Updated
2022/05/15
TCI Chemical
Product number
T3007
Product name
4-(m-Tolylamino)pyridine-3-sulfonamide
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$169
Updated
2024/03/01
TCI Chemical
Product number
T3007
Product name
4-(m-Tolylamino)pyridine-3-sulfonamide
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$834
Updated
2021/12/16
TRC
Product number
M320675
Product name
4-[(3-Methylphenyl)amino]-3-pyridinesulfonamide
Packaging
5g
Price
$300
Updated
2021/12/16
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4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

Torasemide intermediate.

Synthesis

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide is prepared by the reaction of 4-Chloropyridine-3-sulfonamide hydrochloride and 3-Methylaniline. The specific synthesis steps are as follows:
EXAMPLE 1; Preparation of 4-(3-methylphenyl)aminopyridine-sulfonamide; 2L three-neck flask, equipped with a mechanical stirrer, thermometer and condenser, was charged with water (500 ml) and 4-chloro-3- pyridinesulfonamide hydrochloride (100g, 0.44 mol). To this suspension was added m-toluidine (49.2 ml, 0.46 mol) at room temperature. The reaction mixture was heated to 90°C for a minimum period of 3 h. The progress of the reaction was followed by HPLC. After completion, the mixture was cooled to room temperature. The pH of the reaction was then adjusted carefully to pH 7-8 with sat. NaHC03 (ca. 1.1 l). The product was precipitated out and isolated by vacuum filtration as beige solid (126.2 g wet weight). The product was then dissolved in MeOH (1.0 l) at room temperature and charged with Darco KB (25g). The solution was refluxed for 0.5 h and then filtered through a patch of celite to remove Darco KB, while still hot, and rinsed with hot MeOH (200 ML). The filtrate was then charged with water (1.2 l) and stirred for a minimum of 1 h at room temperature. The product, which had precipitated out, was isolated by vacuum filtration to obtain a solid 106.3 g (92percent wet weight =>99.8percent purity a/a). 1H NMR (d6-DMSO) ; 2.30 (s, 3H), 7.00-7. 15 (m. 5H), 7.32 (m, 1H), 7.75 (brs, 1.5H), 8.05 (brs, 0.5H), 8.25 (d, 1H), 8.68 (s, 1H).

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Suppliers

Canada 1 China 251 Europe 2 France 1 Germany 2 India 20 Japan 1 The Netherlands 1 Ukraine 1 United Kingdom 7 United States 32 Global 319
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide 72811-73-5
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-04-30
Hebei Zhanyao Biotechnology Co. Ltd
Product
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide 72811-73-5
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-18
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-(3"-Methylphenyl)amino-3-pyridinesulfonamide 72811-73-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

72811-73-5, 4-(3'-Methylphenyl)amino-3-pyridinesulfonamideRelated Search:

Torasemide Impurity 4-CHLORO-3-PYRIDINESULFONIC ACID 2-Pyridinesulfonamide,4-chloro-(9CI) 4-Hydroxypyridine-3-sulfonic acid 4-Chloro-3-Pyridine-sulfonyl-chloride Torsemide Related Compound 1 [[4-[(3-Methylphenyl)aMino]-3-pyridinyl]sulfonyl]carbaMic Acid Ethyl Ester Torsemide Impurity E 1-Ethyl-3-[[4-(m-toluidino)-3-pyridyl]sulfonyl]urea N-[(n-butylaMino)carbonyl]-4-[(3-Methylphenyl)aMino]-3-pyridinesulfonaMide Torasemide 4-(3-Methylphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazin-3(4H)-one 1,1-Dioxide N-[[(1-Methylethyl-d7)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide 3-Pyridinesulfonamide Sulfamide 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Galosemide TORSEMIDE RELATED COMPOUND A (75 MG) (4-[(3-METHYLPHENYL)AMINO]-3-PYRIDINESULFONAMIDE)

  • Standard for Torasemide Impurity
  • Torasemide Impurity 2（Torasemide EP Impurity B）
  • Torasemide EP Impurity B
  • Torasemide impurity B (EP)
  • 4-[(3-Methylphenyl)amino]-pyridin-3-sulfonamide
  • 4-(-3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE
  • 4-(3'-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE
  • 3-SULFONAMIDO-4-(3-METHYLANILINO)-PYRIDINE
  • SPECS AJ-333/25006115
  • 4-(3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE (SMPAP)
  • 4-[3-Methyl phenyl] amino-3-pyridine sulphonamide
  • Torasemide intermediate
  • [4-(3-Methylphenyl)amino]pyrid
  • 4-(3-methylphenyl)amino-3-pyridine sulfonamide (intermediate of torasemide)
  • 4-(3-methylphenylamino) Pyridine-3-sulfonamide
  • [4-3-Methylphenyl)amino]pyridine-3-sulphonamide
  • 4-(3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE 98%
  • 4-(3'-Methylphenyl)a
  • TorseMide Related CoMpound A
  • BM 960102
  • 4-(M-TolylaMino)pyridine-3-sulfonaMide
  • TorseMide IMpurity B
  • Torsemide USP Related Compound A
  • Torasemi Impurity B Standard
  • 4[(3-Methyl Phenyl) amino] 3-Pyridine Sulfonamide (Torsamide Intermediate) (72811-73-5)
  • 4-[(3-Methylphenyl)amino]pyridine-3
  • Torsemide EP Impurity B
  • 3-Pyridinesulfonamide, 4-[(3-methylphenyl)amino]-
  • 4-(3-Methylphenyl)amino-3-sulfamoylpyridine
  • 4-(m-Tolylamino)-3-sulfamoylpyridine
  • 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide ISO 9001：2015 REACH
  • Torsemide EP Impurity B/ Torsemide Related Compound A
  • Torsemide Impurity BQ: What is Torsemide Impurity B Q: What is the CAS Number of Torsemide Impurity B Q: What is the storage condition of Torsemide Impurity B Q: What are the applications of Torsemide Impurity B
  • TIANFU-CHEM_high purity of 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
  • 4-(3-methylanilinopyridine)-3-sulfonamide
  • Torasemide, Anhydrous Impurity B
  • Torasemide, Anhydrous EP Impurity B
  • 4-(3-Methylphenyl)Amino-3-Pyridinesulfonamide (Torsemide Intermediate)
  • Torsemide Imp B
  • 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
  • TORSEMIDE EP IMP B
  • Torasemide (Torsemide) EP Impurity B (Torasemide (Torsemide) USP Related Compound A)
  • 72811-73-5
  • C12H13N3O2S
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • INTERMEDIATESOFTORASEMIDE
  • Pyridines derivates
  • (intermediate of torasemide)
  • Pyridines
  • Torsemide
  • 72811-73-5