4-(3'-Methylphenyl)amino-3-pyridinesulfonamide

ChemicalBook > CAS DataBase List > 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide

Product Name: 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
CAS No.: 72811-73-5
Chemical Name: 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
Synonyms: BM 960102;Torsemide Imp B;TORSEMIDE EP IMP B;4-(3'-Methylphenyl)a;TorseMide IMpurity B;SPECS AJ-333/25006115;Torasemide intermediate;Torsemide EP Impurity B;Torasemide EP Impurity B;Torasemide impurity B (EP)
CBNumber: CB0486466
Molecular Formula: C12H13N3O2S
Formula Weight: 263.32
MOL File: 72811-73-5.mol

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4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Property

Melting point:: 162-164?C
Boiling point:: 475.8±55.0 °C(Predicted)
Density: 1.357±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 9.53±0.60(Predicted)
color: White to Off-White
BRN: 5438165
InChIKey: ZXPCUGWAKUIOOF-UHFFFAOYSA-N
CAS DataBase Reference: 72811-73-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
HS Code: 2935909550

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1672315
Product name: Torsemide Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 75mg
Price: $1630
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR3145
Product name: Torsemide Related Compound A
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 150MG
Price: $466
Updated: 2022/05/15

TCI Chemical

Product number: T3007
Product name: 4-(m-Tolylamino)pyridine-3-sulfonamide
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $169
Updated: 2024/03/01

TCI Chemical

Product number: T3007
Product name: 4-(m-Tolylamino)pyridine-3-sulfonamide
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $834
Updated: 2021/12/16

TRC

Product number: M320675
Product name: 4-[(3-Methylphenyl)amino]-3-pyridinesulfonamide
Packaging: 5g
Price: $300
Updated: 2021/12/16

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4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

Torasemide intermediate.

Synthesis

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide is prepared by the reaction of 4-Chloropyridine-3-sulfonamide hydrochloride and 3-Methylaniline. The specific synthesis steps are as follows:
EXAMPLE 1; Preparation of 4-(3-methylphenyl)aminopyridine-sulfonamide; 2L three-neck flask, equipped with a mechanical stirrer, thermometer and condenser, was charged with water (500 ml) and 4-chloro-3- pyridinesulfonamide hydrochloride (100g, 0.44 mol). To this suspension was added m-toluidine (49.2 ml, 0.46 mol) at room temperature. The reaction mixture was heated to 90°C for a minimum period of 3 h. The progress of the reaction was followed by HPLC. After completion, the mixture was cooled to room temperature. The pH of the reaction was then adjusted carefully to pH 7-8 with sat. NaHC03 (ca. 1.1 l). The product was precipitated out and isolated by vacuum filtration as beige solid (126.2 g wet weight). The product was then dissolved in MeOH (1.0 l) at room temperature and charged with Darco KB (25g). The solution was refluxed for 0.5 h and then filtered through a patch of celite to remove Darco KB, while still hot, and rinsed with hot MeOH (200 ML). The filtrate was then charged with water (1.2 l) and stirred for a minimum of 1 h at room temperature. The product, which had precipitated out, was isolated by vacuum filtration to obtain a solid 106.3 g (92percent wet weight =>99.8percent purity a/a). 1H NMR (d6-DMSO) ; 2.30 (s, 3H), 7.00-7. 15 (m. 5H), 7.32 (m, 1H), 7.75 (brs, 1.5H), 8.05 (brs, 0.5H), 8.25 (d, 1H), 8.68 (s, 1H).

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide 72811-73-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-04-30

Hebei Zhanyao Biotechnology Co. Ltd

Product: 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide 72811-73-5
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-18

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(3"-Methylphenyl)amino-3-pyridinesulfonamide 72811-73-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

72811-73-5, 4-(3'-Methylphenyl)amino-3-pyridinesulfonamideRelated Search:

Torasemide Impurity 4-CHLORO-3-PYRIDINESULFONIC ACID 2-Pyridinesulfonamide,4-chloro-(9CI) 4-Hydroxypyridine-3-sulfonic acid 4-Chloro-3-Pyridine-sulfonyl-chloride Torsemide Related Compound 1 [[4-[(3-Methylphenyl)aMino]-3-pyridinyl]sulfonyl]carbaMic Acid Ethyl Ester Torsemide Impurity E 1-Ethyl-3-[[4-(m-toluidino)-3-pyridyl]sulfonyl]urea N-[(n-butylaMino)carbonyl]-4-[(3-Methylphenyl)aMino]-3-pyridinesulfonaMide Torasemide 4-(3-Methylphenyl)-2H-pyrido[4,3-e]-1,2,4-thiadiazin-3(4H)-one 1,1-Dioxide N-[[(1-Methylethyl-d7)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide 3-Pyridinesulfonamide Sulfamide 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Galosemide TORSEMIDE RELATED COMPOUND A (75 MG) (4-[(3-METHYLPHENYL)AMINO]-3-PYRIDINESULFONAMIDE)

Standard for Torasemide Impurity

Torasemide Impurity 2（Torasemide EP Impurity B）

Torasemide EP Impurity B

Torasemide impurity B (EP)

4-[(3-Methylphenyl)amino]-pyridin-3-sulfonamide

4-(-3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE

4-(3'-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE

3-SULFONAMIDO-4-(3-METHYLANILINO)-PYRIDINE

SPECS AJ-333/25006115

4-(3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE (SMPAP)

4-[3-Methyl phenyl] amino-3-pyridine sulphonamide

Torasemide intermediate

[4-(3-Methylphenyl)amino]pyrid

4-(3-methylphenyl)amino-3-pyridine sulfonamide (intermediate of torasemide)

4-(3-methylphenylamino) Pyridine-3-sulfonamide

[4-3-Methylphenyl)amino]pyridine-3-sulphonamide

4-(3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE 98%

4-(3'-Methylphenyl)a

TorseMide Related CoMpound A

BM 960102

4-(M-TolylaMino)pyridine-3-sulfonaMide

TorseMide IMpurity B

Torsemide USP Related Compound A

Torasemi Impurity B Standard

4[(3-Methyl Phenyl) amino] 3-Pyridine Sulfonamide (Torsamide Intermediate) (72811-73-5)

4-[(3-Methylphenyl)amino]pyridine-3

Torsemide EP Impurity B

3-Pyridinesulfonamide, 4-[(3-methylphenyl)amino]-

4-(3-Methylphenyl)amino-3-sulfamoylpyridine

4-(m-Tolylamino)-3-sulfamoylpyridine

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide ISO 9001：2015 REACH

Torsemide EP Impurity B/ Torsemide Related Compound A

Torsemide Impurity BQ: What is Torsemide Impurity B Q: What is the CAS Number of Torsemide Impurity B Q: What is the storage condition of Torsemide Impurity B Q: What are the applications of Torsemide Impurity B

TIANFU-CHEM_high purity of 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide

4-(3-methylanilinopyridine)-3-sulfonamide

Torasemide, Anhydrous Impurity B

Torasemide, Anhydrous EP Impurity B

4-(3-Methylphenyl)Amino-3-Pyridinesulfonamide (Torsemide Intermediate)

Torsemide Imp B

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide

TORSEMIDE EP IMP B

Torasemide (Torsemide) EP Impurity B (Torasemide (Torsemide) USP Related Compound A)

72811-73-5

C12H13N3O2S

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

INTERMEDIATESOFTORASEMIDE

Pyridines derivates

(intermediate of torasemide)

Pyridines

Torsemide

72811-73-5