Cetylpyridinium chloride
- Product Name
- Cetylpyridinium chloride
- CAS No.
- 123-03-5
- Chemical Name
- Cetylpyridinium chloride
- Synonyms
- 1-palmitylpyridiniumchloride;1-HEXADECYLPYRIDINIUM CHLORIDE;ceprim;ceepryn;cepacol;aktivex;biosept;merocet;cetamium;dobendan
- CBNumber
- CB0492441
- Molecular Formula
- C21H38ClN
- Formula Weight
- 339.99
- MOL File
- 123-03-5.mol
Cetylpyridinium chloride Property
- Melting point:
- 77°C
- Boiling point:
- 496.25°C (rough estimate)
- Density
- 0.9362 (rough estimate)
- vapor pressure
- 0Pa at 25℃
- refractive index
- 1.6000 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Freely soluble in water; very soluble in chloroform; very slightly soluble in ether; insoluble in acetone, acetic acid, and ethanol.
- form
- White Crystalline Powder
- Odor
- at 100.00?%. pyridine
- Water Solubility
- 111g/L at 20℃
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
- LogP
- 1.71 at 20℃
- CAS DataBase Reference
- 123-03-5(CAS DataBase Reference)
- EPA Substance Registry System
- Cetylpyridinium chloride (123-03-5)
Safety
- RIDADR
- 2811
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 2933399990
- Hazardous Substances Data
- 123-03-5(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H330Fatal if inhaled
H335May cause respiratory irritation
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 21983
- Product name
- Cetylpyridinium (chloride)
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $26
- Updated
- 2024/03/01
- Product number
- 21983
- Product name
- Cetylpyridinium (chloride)
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $68
- Updated
- 2023/06/20
- Product number
- 21983
- Product name
- Cetylpyridinium (chloride)
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $106
- Updated
- 2023/06/20
- Product number
- 21983
- Product name
- Cetylpyridinium (chloride)
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $373
- Updated
- 2023/06/20
- Product number
- C281605
- Product name
- Cetylpyridinium chloride
- Packaging
- 25g
- Price
- $185
- Updated
- 2021/12/16
Cetylpyridinium chloride Chemical Properties,Usage,Production
Description
Cetylpyridinium is a quaternary ammonium with broad-spectrum antiseptic activities. It is active against S. mutans, S. sanguis, E. coli, Oxford Staphylococcus, and C. albicans in media (MICs = 1.25-62.5 μg/ml) and against Oxford Staphylococcus in pooled human saliva (MICs = 7.8-15.6 μg/ml). Cetylpyridinium slows plaque formation for at least 21 days compared to a deionized water control in a rat incisor plaque model when applied topically at concentrations ranging from 0.025 to 2%. Formulations containing cetylpyridinium have been used as antiseptic agents in the treatment of gingivitis and as antimicrobial agents in raw food processing.
Chemical Properties
Cetylpyridinium chloride (CPC) is a white powder or crystals with a characteristic odor. It is slightly soapy to the touch.
Cetylpyridinium chloride is a quaternary ammonium compound and is the active chemical in some human mouthwashes on the market. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat. The antimicrobial activity is due to an interaction of basic cetylpyridinium ions with acidic molecules on bacteria, which subsequently inhibits bacterial metabolism by forming weak ionic compounds that interfere with bacterial respiration.
Uses
quaternary ammonium compound used as a preservative in cosmetics and pharmaceuticals; topical anti-infective and disinfectant; used on the surface of latex gloves .
Uses
Antibacterial in cough lozenges and syrups; emulsifier.
Definition
ChEBI: A pyridinium salt that has N-hexadecylpyridinium as the cation and chloride as the anion. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat.
Production Methods
Cetylpyridinium chloride is prepared from cetyl chloride by treatment with pyridine.
brand name
Ceepryn (Marion Merrell Dow); Cepacol (Marion Merrell Dow).
Flammability and Explosibility
Non flammable
Pharmaceutical Applications
Cetylpyridinium chloride is a quaternary ammonium cationic
surfactant, used in pharmaceutical and cosmetic formulations as
an antimicrobial preservative. It is used therapeutically
as an antiseptic agent; used alone or in combination with
other drugs for oral and throat care; used in nonparenteral
formulations licensed in the UK; and used in oral and inhalation
preparations at concentrations of 0.02–1.5 mg.
Mouthwashes containing cetylpyridinium chloride have been
shown to inhibit plaque formation,(1–3) although efficacy is variable
owing to limited published data.
Clinical Use
1-Hexadecylpyridinium chloride is a white powder that isvery soluble in water and alcohol. In this compound, thequaternary nitrogen atom is a member of an aromatic pyridinering.
The cetyl derivative is the most active of a series ofalkylpyridinium compounds. It is used as a general antisepticin concentrations of 1:100 to 1:1,000 for intact skin,1:1,000 for minor lacerations, and 1:2,000 to 1:10,000 forthe irrigation of mucous membranes. Cetylpyridinium chlorideis also available in the form of throat lozenges and amouthwash at a 1:20,000 dilution.
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by skin contact. A skin and eye irritant. When E heated to decomposiuon it emits very toxic fumes of NOx and Cl-.
Safety
Cetylpyridinium chloride is used widely in mouthwashes as a
bactericidal antiseptic. It is generally regarded as a relatively
nontoxic material when used at a concentration of 0.05% w/v,
although minor side effects such as mild burning sensations on the
tongue have been reported.
At higher concentrations, cetylpyridinium chloride may damage
the mucous membranes in the mouth. It is harmful when ingested or
inhaled. It can cause eye irritation, and is irritant to the respiratory
system and the skin.
LD50 (rat, IP): 0.006 g/kg
LD50 (rat, IV): 0.03 g/kg
LD50 (rat, oral): 0.2 g/kg
LD50 (rat, SC): 0.25 g/kg
LD50 (mouse, IP): 0.01 g/kg
LD50 (mouse, oral): 0.108 g/kg
LD50 (rabbit, oral): 0.4 g/kg
LD50 (rabbit, IV): 0.036 g/kg
storage
Cetylpyridinium chloride is stable under normal conditions. It should be stored in well-closed containers.
Incompatibilities
Incompatible with strong oxidizing agents and bases. It is also
incompatible with methylcellulose.
Magnesium stearate suspensions in cetylpyridinium chloride
have been shown to significantly reduce its antimicrobial activity.
This is due to the absorption of cetylpyridinium chloride on
magnesium stearate. The cetylpyridinium chloride ion also
interacts with gelatin, resulting in reduced bioavailability.
Regulatory Status
Included in nonparenteral formulations licensed in the UK. Included in the FDA Inactive Ingredients Database, for use in inhalation and oral preparations. Reported in the EPA TSCA Inventory. It is not approved for use in Japan. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Cetylpyridinium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cetylpyridinium chloride manufacturers
- Product
- cetylpyridinium chloride 123-03-5
- Price
- US $15.00/kg
- Min. Order
- 1kg
- Purity
- 99.912%
- Supply Ability
- 10ton
- Release date
- 2024-04-24
- Product
- cetylpyridinium chloride 123-03-5
- Price
- US $70.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-04-23
- Product
- cetylpyridinium chloride 123-03-5
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-09