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Cetylpyridinium chloride

Product Name
Cetylpyridinium chloride
CAS No.
123-03-5
Chemical Name
Cetylpyridinium chloride
Synonyms
1-palmitylpyridiniumchloride;1-HEXADECYLPYRIDINIUM CHLORIDE;ceprim;ceepryn;cepacol;aktivex;biosept;merocet;cetamium;dobendan
CBNumber
CB0492441
Molecular Formula
C21H38ClN
Formula Weight
339.99
MOL File
123-03-5.mol
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Cetylpyridinium chloride Property

Melting point:
77°C
Boiling point:
496.25°C (rough estimate)
Density 
0.9362 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.6000 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Freely soluble in water; very soluble in chloroform; very slightly soluble in ether; insoluble in acetone, acetic acid, and ethanol.
form 
White Crystalline Powder
color 
White to off-white
Odor
at 100.00?%. pyridine
Water Solubility 
111g/L at 20℃
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
LogP
1.71 at 20℃
CAS DataBase Reference
123-03-5(CAS DataBase Reference)
EPA Substance Registry System
Cetylpyridinium chloride (123-03-5)
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Safety

RIDADR 
2811
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2933399990
Hazardous Substances Data
123-03-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H330Fatal if inhaled

H335May cause respiratory irritation

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21983
Product name
Cetylpyridinium (chloride)
Purity
≥98%
Packaging
100mg
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
21983
Product name
Cetylpyridinium (chloride)
Purity
≥98%
Packaging
250mg
Price
$68
Updated
2023/06/20
Cayman Chemical
Product number
21983
Product name
Cetylpyridinium (chloride)
Purity
≥98%
Packaging
1g
Price
$106
Updated
2023/06/20
Cayman Chemical
Product number
21983
Product name
Cetylpyridinium (chloride)
Purity
≥98%
Packaging
5g
Price
$373
Updated
2023/06/20
TRC
Product number
C281605
Product name
Cetylpyridinium chloride
Packaging
25g
Price
$185
Updated
2021/12/16
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Cetylpyridinium chloride Chemical Properties,Usage,Production

Description

Cetylpyridinium is a quaternary ammonium with broad-spectrum antiseptic activities. It is active against S. mutans, S. sanguis, E. coli, Oxford Staphylococcus, and C. albicans in media (MICs = 1.25-62.5 μg/ml) and against Oxford Staphylococcus in pooled human saliva (MICs = 7.8-15.6 μg/ml). Cetylpyridinium slows plaque formation for at least 21 days compared to a deionized water control in a rat incisor plaque model when applied topically at concentrations ranging from 0.025 to 2%. Formulations containing cetylpyridinium have been used as antiseptic agents in the treatment of gingivitis and as antimicrobial agents in raw food processing.

Chemical Properties

Cetylpyridinium chloride (CPC) is a white powder or crystals with a characteristic odor. It is slightly soapy to the touch.

Cetylpyridinium chloride is a quaternary ammonium compound and is the active chemical in some human mouthwashes on the market. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat. The antimicrobial activity is due to an interaction of basic cetylpyridinium ions with acidic molecules on bacteria, which subsequently inhibits bacterial metabolism by forming weak ionic compounds that interfere with bacterial respiration.

Uses

quaternary ammonium compound used as a preservative in cosmetics and pharmaceuticals; topical anti-infective and disinfectant; used on the surface of latex gloves .

Uses

Antibacterial in cough lozenges and syrups; emulsifier.

Definition

ChEBI: A pyridinium salt that has N-hexadecylpyridinium as the cation and chloride as the anion. It has antiseptic properties and is used in solutions or lozenges for the treatment of minor infections of the mouth and throat.

Production Methods

Cetylpyridinium chloride is prepared from cetyl chloride by treatment with pyridine.

brand name

Ceepryn (Marion Merrell Dow); Cepacol (Marion Merrell Dow).

Flammability and Explosibility

Non flammable

Pharmaceutical Applications

Cetylpyridinium chloride is a quaternary ammonium cationic surfactant, used in pharmaceutical and cosmetic formulations as an antimicrobial preservative. It is used therapeutically as an antiseptic agent; used alone or in combination with other drugs for oral and throat care; used in nonparenteral formulations licensed in the UK; and used in oral and inhalation preparations at concentrations of 0.02–1.5 mg.
Mouthwashes containing cetylpyridinium chloride have been shown to inhibit plaque formation,(1–3) although efficacy is variable owing to limited published data.

Clinical Use

1-Hexadecylpyridinium chloride is a white powder that isvery soluble in water and alcohol. In this compound, thequaternary nitrogen atom is a member of an aromatic pyridinering.
The cetyl derivative is the most active of a series ofalkylpyridinium compounds. It is used as a general antisepticin concentrations of 1:100 to 1:1,000 for intact skin,1:1,000 for minor lacerations, and 1:2,000 to 1:10,000 forthe irrigation of mucous membranes. Cetylpyridinium chlorideis also available in the form of throat lozenges and amouthwash at a 1:20,000 dilution.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by skin contact. A skin and eye irritant. When E heated to decomposiuon it emits very toxic fumes of NOx and Cl-.

Safety

Cetylpyridinium chloride is used widely in mouthwashes as a bactericidal antiseptic. It is generally regarded as a relatively nontoxic material when used at a concentration of 0.05% w/v, although minor side effects such as mild burning sensations on the tongue have been reported.
At higher concentrations, cetylpyridinium chloride may damage the mucous membranes in the mouth. It is harmful when ingested or inhaled. It can cause eye irritation, and is irritant to the respiratory system and the skin.
LD50 (rat, IP): 0.006 g/kg
LD50 (rat, IV): 0.03 g/kg
LD50 (rat, oral): 0.2 g/kg
LD50 (rat, SC): 0.25 g/kg
LD50 (mouse, IP): 0.01 g/kg
LD50 (mouse, oral): 0.108 g/kg
LD50 (rabbit, oral): 0.4 g/kg
LD50 (rabbit, IV): 0.036 g/kg

storage

Cetylpyridinium chloride is stable under normal conditions. It should be stored in well-closed containers.

Incompatibilities

Incompatible with strong oxidizing agents and bases. It is also incompatible with methylcellulose.
Magnesium stearate suspensions in cetylpyridinium chloride have been shown to significantly reduce its antimicrobial activity. This is due to the absorption of cetylpyridinium chloride on magnesium stearate. The cetylpyridinium chloride ion also interacts with gelatin, resulting in reduced bioavailability.

Regulatory Status

Included in nonparenteral formulations licensed in the UK. Included in the FDA Inactive Ingredients Database, for use in inhalation and oral preparations. Reported in the EPA TSCA Inventory. It is not approved for use in Japan. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Cetylpyridinium chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Cetylpyridinium chloride Suppliers

Shengbaolai Biotechnology Co., Ltd
Tel
86-027-59105235 15527244834
Email
shengblai@126.com
Country
China
ProdList
496
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58
Jiangsu Huayu Chemical Co., Ltd.
Tel
25-83241163
Fax
+86-25-83241173
Email
sales@elegantnutri.com
Country
China
ProdList
55
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55
Shanghai Yuanyuan Biotechnology Co. , Ltd.
Tel
021-58796960 13585883992
Email
herochem021@163.com
Country
China
ProdList
27
Advantage
58
Wuhan Xinli Biotechnology Co., Ltd
Tel
027-027-83305579 13697349395
Fax
027-83305570
Email
409374507@qq.com
Country
China
ProdList
27
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58
Shandong Chenyi Environmental Protection Technology Co., Ltd
Tel
0531-83179999 13395316108
Email
cyhbkjyxgs@163.com
Country
China
ProdList
126
Advantage
58
Jubilant Life Sciences(Shanghai)Ltd.
Tel
021-63907388-21 18017369769
Email
jerry_zhang@jubl.com
Country
China
ProdList
188
Advantage
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LANZHOU DAYUAN NEW MATERIAL TECHNOLOGY CO.,LTD
Tel
13992067598 13992067598
Email
wpthisage@163.com
Country
China
ProdList
5
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
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61
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View Lastest Price from Cetylpyridinium chloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
cetylpyridinium chloride 123-03-5
Price
US $70.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-04-23
Hebei Weibang Biotechnology Co., Ltd
Product
Cetylpyridinium chloride 123-03-5
Price
US $1.00/PCS
Min. Order
1PCS
Purity
99%
Supply Ability
10 mt
Release date
2024-10-28
airuikechemical co., ltd.
Product
cetylpyridinium chloride 123-03-5
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-09

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