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D-Fructose 1,6-bisphosphate trisodium salt

Biochem/physiol Actions
Product Name
D-Fructose 1,6-bisphosphate trisodium salt
CAS No.
38099-82-0
Chemical Name
D-Fructose 1,6-bisphosphate trisodium salt
Synonyms
FDP,3Na;FDP-Na3H;D-Fructose-1;FDP trisodium;Einecs 253-778-0;HARDEN-YOUNG ESTER;HEXOSE DIPHOSPHATE;Esafosfan trisodium;hexose diphosphoric acid;Diphosphofructose trisodium
CBNumber
CB0493640
Molecular Formula
C6H15NaO12P2
Formula Weight
364.11
MOL File
38099-82-0.mol
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D-Fructose 1,6-bisphosphate trisodium salt Property

Melting point:
127°C
storage temp. 
−20°C
form 
Powder
color 
White to off-white
Water Solubility 
Soluble in water at 50mg/ml
EPA Substance Registry System
D-Fructose, 1,6-bis(dihydrogen phosphate), trisodium salt (38099-82-0)
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Safety

WGK Germany 
3
10-21
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F6803
Product name
D-Fructose 1,6-bisphosphate trisodium salt hydrate
Purity
≥98% (TLC)
Packaging
1g
Price
$92.9
Updated
2024/03/01
Sigma-Aldrich
Product number
F6803
Product name
D-Fructose 1,6-bisphosphate trisodium salt hydrate
Purity
≥98% (TLC)
Packaging
5g
Price
$322
Updated
2024/03/01
Alfa Aesar
Product number
J66349
Product name
D-Fructose-1,6-bisphosphate trisodium salt
Packaging
1g
Price
$19.65
Updated
2024/03/01
Alfa Aesar
Product number
J66349
Product name
D-Fructose-1,6-bisphosphate trisodium salt
Packaging
25g
Price
$99.65
Updated
2024/03/01
Sigma-Aldrich
Product number
F6803
Product name
D-Fructose 1,6-bisphosphate trisodium salt hydrate
Purity
≥98% (TLC)
Packaging
10mg
Price
$31.4
Updated
2024/03/01
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D-Fructose 1,6-bisphosphate trisodium salt Chemical Properties,Usage,Production

Biochem/physiol Actions

Fructose-1,6-biphosphate (F1,6P) is a glycolytic intermediate produced by the transfer of a phosphate from ATP to fructose-6-phosphate by the enzyme phosphofructokinase. Fructose-1,6-biphosphate, along with fructose-2,6-biphosphate, modulates the activity of phosphofructokinase-1 (PFK-1), the rate-limiting step in glycolysis. During glycolysis, aldolase splits Fructose-1,6-biphosphate into dihydroxacetone phosphate (DHAP) and glyceraldehyde phosphate. Fructose-1,6-biphosphate is also an allosteric activator of the M2 isoform of Pyruvate Kinase (PK-M2), the predominant form of pyruvate kinase in cancer cells.

Uses

D-Fructose-1,6-bisphosphate trisodium salt is used to reduce ischemia-reperfusion injury in rats.

Application

D-Fructose-1,6-bisphosphate (FBP), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It may be used as an allosteric activator of enzymes such as pyruvate kinase and NAD+-dependent L-(+)-lactate dehydrogenase, as an inhibitor of acetate kinase and as a substrate to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1,6-bisphosphatase(s). FBP is studied as a neuroprotective agent in brain injury.

Purification Methods

Fructose-1,6-diphosphate is best purified via the acid strychnine salt which is stable for several months. To remove the strychnine, dissolve 5g in H2O (150mL), and add 5N NaOH (or KOH to obtain the K salt) to pH 8.3 (phenolphthalein) with vigorous stirring. Remove the precipitate by centrifugation, wash with cold H2O (2x 25mL), extract with CHCl3 until the extract is free of strychnine (ca 8 to 10times, Mandelein spot test). Freeze-dry the aqueous solution to give the Na salt which is hygroscopic. It has been recrystallised from aqueous EtOH as the octahydrate, m 125o, [] D +2.6o (c 1, H2O). A neutral solution of the salt keeps well in a frozen state for over several months. [Neuberg et al. Arch Biochem 3 33 1943, Sable Biochemical Preparations 2 52 1952, Stumpf J Biol Chem 182 261 1950]. The calcium salt can be partially purified by dissolving in ice-cold N HCl (1g per 10mL) and re-precipitating by dropwise addition of 2N NaOH: the precipitate and supernatant are heated on a boiling water bath for a short time, then filtered, and the precipitate is washed with hot water. The magnesium salt can be precipitated from a cold aqueous solution by adding four volumes of EtOH. The tetramethyl ester is an oil with n D 1.4648, [] 18 +20.2 (c 0.4, MeOH). [Schulbach & Rauchenberger Chem Ber 60 1178 1927, Beilstein 1 IV 4424.]

D-Fructose 1,6-bisphosphate trisodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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D-Fructose 1,6-bisphosphate trisodium salt Suppliers

Hebei Zhongbei Jiamei Biological Technology Co., Ltd.
Tel
0311-89171450 15373918792
Email
3265217077@qq.com
Country
China
ProdList
45
Advantage
58
Jiangsu Huayu Chemical Co., Ltd.
Tel
25-83241163
Fax
+86-25-83241173
Email
sales@elegantnutri.com
Country
China
ProdList
55
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
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View Lastest Price from D-Fructose 1,6-bisphosphate trisodium salt manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
D-Fructose 1,6-bisphosphate trisodium salt 38099-82-0
Price
US $0.00/G
Min. Order
1G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-20
Hebei ZB Gamay Biological Technology Co.,Ltd
Product
Fructose Diphosphate Sodium 38099-82-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2022-11-22
Hebei Mojin Biotechnology Co., Ltd
Product
D-Fructose 1,6-bisphosphate trisodium salt 38099-82-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2024-10-22

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