D-Fructose 1,6-bisphosphate trisodium salt

ChemicalBook > CAS DataBase List > D-Fructose 1,6-bisphosphate trisodium salt

D-Fructose 1,6-bisphosphate trisodium salt

Biochem/physiol Actions

Product Name: D-Fructose 1,6-bisphosphate trisodium salt
CAS No.: 38099-82-0
Chemical Name: D-Fructose 1,6-bisphosphate trisodium salt
Synonyms: FDP,3Na;FDP-Na3H;D-Fructose-1;FDP trisodium;Einecs 253-778-0;HARDEN-YOUNG ESTER;HEXOSE DIPHOSPHATE;Esafosfan trisodium;hexose diphosphoric acid;Diphosphofructose trisodium
CBNumber: CB0493640
Molecular Formula: C6H15NaO12P2
Formula Weight: 364.11
MOL File: 38099-82-0.mol

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D-Fructose 1,6-bisphosphate trisodium salt Property

Melting point:: 127°C
storage temp.: −20°C
form: Powder
color: White to off-white
Water Solubility: Soluble in water at 50mg/ml
EPA Substance Registry System: D-Fructose, 1,6-bis(dihydrogen phosphate), trisodium salt (38099-82-0)

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Safety

WGK Germany: 3
F: 10-21

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F6803
Product name: D-Fructose 1,6-bisphosphate trisodium salt hydrate
Purity: ≥98% (TLC)
Packaging: 1g
Price: $92.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: F6803
Product name: D-Fructose 1,6-bisphosphate trisodium salt hydrate
Purity: ≥98% (TLC)
Packaging: 5g
Price: $322
Updated: 2024/03/01

Alfa Aesar

Product number: J66349
Product name: D-Fructose-1,6-bisphosphate trisodium salt
Packaging: 1g
Price: $19.65
Updated: 2024/03/01

Alfa Aesar

Product number: J66349
Product name: D-Fructose-1,6-bisphosphate trisodium salt
Packaging: 25g
Price: $99.65
Updated: 2024/03/01

Sigma-Aldrich

Product number: F6803
Product name: D-Fructose 1,6-bisphosphate trisodium salt hydrate
Purity: ≥98% (TLC)
Packaging: 10mg
Price: $31.4
Updated: 2024/03/01

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D-Fructose 1,6-bisphosphate trisodium salt Chemical Properties,Usage,Production

Biochem/physiol Actions

Fructose-1,6-biphosphate (F1,6P) is a glycolytic intermediate produced by the transfer of a phosphate from ATP to fructose-6-phosphate by the enzyme phosphofructokinase. Fructose-1,6-biphosphate, along with fructose-2,6-biphosphate, modulates the activity of phosphofructokinase-1 (PFK-1), the rate-limiting step in glycolysis. During glycolysis, aldolase splits Fructose-1,6-biphosphate into dihydroxacetone phosphate (DHAP) and glyceraldehyde phosphate. Fructose-1,6-biphosphate is also an allosteric activator of the M2 isoform of Pyruvate Kinase (PK-M2), the predominant form of pyruvate kinase in cancer cells.

Uses

D-Fructose-1,6-bisphosphate trisodium salt is used to reduce ischemia-reperfusion injury in rats.

Application

D-Fructose-1,6-bisphosphate (FBP), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It may be used as an allosteric activator of enzymes such as pyruvate kinase and NAD+-dependent L-(+)-lactate dehydrogenase, as an inhibitor of acetate kinase and as a substrate to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1,6-bisphosphatase(s). FBP is studied as a neuroprotective agent in brain injury.

Purification Methods

Fructose-1,6-diphosphate is best purified via the acid strychnine salt which is stable for several months. To remove the strychnine, dissolve 5g in H2O (150mL), and add 5N NaOH (or KOH to obtain the K salt) to pH 8.3 (phenolphthalein) with vigorous stirring. Remove the precipitate by centrifugation, wash with cold H2O (2x 25mL), extract with CHCl3 until the extract is free of strychnine (ca 8 to 10times, Mandelein spot test). Freeze-dry the aqueous solution to give the Na salt which is hygroscopic. It has been recrystallised from aqueous EtOH as the octahydrate, m 125o, [] D +2.6o (c 1, H2O). A neutral solution of the salt keeps well in a frozen state for over several months. [Neuberg et al. Arch Biochem 3 33 1943, Sable Biochemical Preparations 2 52 1952, Stumpf J Biol Chem 182 261 1950]. The calcium salt can be partially purified by dissolving in ice-cold N HCl (1g per 10mL) and re-precipitating by dropwise addition of 2N NaOH: the precipitate and supernatant are heated on a boiling water bath for a short time, then filtered, and the precipitate is washed with hot water. The magnesium salt can be precipitated from a cold aqueous solution by adding four volumes of EtOH. The tetramethyl ester is an oil with n D 1.4648, [] 18 +20.2 (c 0.4, MeOH). [Schulbach & Rauchenberger Chem Ber 60 1178 1927, Beilstein 1 IV 4424.]

D-Fructose 1,6-bisphosphate trisodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from D-Fructose 1,6-bisphosphate trisodium salt manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: D-Fructose 1,6-bisphosphate trisodium salt 38099-82-0
Price: US $0.00/G
Min. Order: 1G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-20

Hebei ZB Gamay Biological Technology Co.,Ltd

Product: Fructose Diphosphate Sodium 38099-82-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2022-11-22

Hebei Mujin Biotechnology Co.,Ltd

Product: D-Fructose 1,6-bisphosphate trisodium salt 38099-82-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2024-10-22

38099-82-0, D-Fructose 1,6-bisphosphate trisodium saltRelated Search:

D-fructose 6-(dihydrogen phosphate) Fructose sodium diphosphate Sodium citrate Trisodium phosphate D(-)-Fructose D-Fructose-1,6-diphosphate trisodium salt octahydrate chlorinated sodium phosphate beta-D-Fructopyranose FRUCTOSE Sodium phosphate tribasic dodecahydrate D-FRUCTOSE 2,6-DIPHOSPHATE, SODIUM SALT HYDRATE D-FRUCTOSE 1,6-DIPHOSPHATE SODIUM SALT trisodium D-FRUCTOSE 1,6-DIPHOSPHATE-UL-14C TETRASODIUM SALT D-Fructose 1,6-bisphosphate trisodium salt

acetic acid (12-acetyloxy-6,11-dioxo-1,2,3,4-tetrahydrotetracen-5-yl) ester

FDP-Na3H

D(+)FRUCTOFURANOSE 1,6-DIPHOSPHATE TRISODIUM SALT

D-FruCLose 1,6-bisphosphate trisodiuM salt

D-Fructose 1,6-bisphosphate hydrate trisodium salt

Harden-Young ester, Hexose diphosphate hydrate trisodium salt, D(+)Fructofuranose 1,6-diphosphate hydrate trisodium salt

D-Fructose-1,6-biphosphate trisodium salt octahydrate

HEXOSE DIPHOSPHATE TRISODIUM SALT

HEXOSE DIPHOSPHATE

HARDEN-YOUNG ESTER

D-Fructose 1,6-bisphosphate trisodium salt octahydrate

D-FRUCTOSE-1 6-DIPHOSPHORIC ACID TRISOD&

hexose diphosphoric acid

D-Fructose, 1,6-bis(dihydrogen phosphate), sodium salt (1:3)

Einecs 253-778-0

Fructose-1,6-bis(dihydrophosphate), trisodium salt

Hexose diphosphate trisodium salt hydrate

6-diphosphate trisodiuM salt octahydrate

D-Fructose-1

D-Fructose 1,6-bisphosphate trisodium salt anhydrous

D-FRUCTOSE 1,6-BISPHOSPHATE TRISODIUM SALT

D-FRUCTOSE 1,6-DIPHOSPHATE TRISODIUM SALT

d-fructose,1,6-bis(dihydrogenphosphate),trisodiumsalt

D-Fructose-1,6-Phosphate trisodiuM salt

D(+)Fructofuranose 1,6-diphosphate trisodium salt hydrate

D-Fructose 1,6-bisphosphate sodium salt

FDP,3Na

FDP trisodium

Esafosfan trisodium

Diphosphofructose trisodium

D-Fructose1,6-bisphosphatetrisodiumsal

D-Fructose 1,6-bisphosphate trisodium salt hydrate, ≥98%

Fructose bisphosphate sodium/Fosfructose trisodium

Fosfructose trisodium (Diphosphofructose (trisodium))

Fosfructose trisodium|||D-Fructose-1,6-diphosphate trisodium salt octahydrate|||FDP trisodium|||Diphosphofructose trisodium

D-Fructose 1,6-diphosphate trisodium salt, Common metabolic sugar

38099-82-0

C6H11Na3O12P2

C6H10O4OPO3H22

Carbohydrates

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Monosaccharide

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