4-BROMO-2-METHOXY-BENZONITRILE

Product Name: 4-BROMO-2-METHOXY-BENZONITRILE
CAS No.: 330793-38-9
Chemical Name: 4-BROMO-2-METHOXY-BENZONITRILE
Synonyms: 4-BROMO-2-METHOXY-BENZONITRILE;Benzonitrile, 4-bromo-2-methoxy-
CBNumber: CB0494283
Molecular Formula: C8H6BrNO
Formula Weight: 212.04
MOL File: 330793-38-9.mol

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4-BROMO-2-METHOXY-BENZONITRILE Property

Boiling point:: 289.1±20.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: crystalline solid
color: Off-white

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Safety

Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39
RIDADR: 3439
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 072472
Product name: 4-Bromo-2-methoxybenzonitrile
Purity: 95+%
Packaging: 1g
Price: $10
Updated: 2021/12/16

AK Scientific

Product number: AMTH100
Product name: 4-Bromo-2-methoxybenzonitrile
Packaging: 5g
Price: $30
Updated: 2021/12/16

Matrix Scientific

Product number: 072472
Product name: 4-Bromo-2-methoxybenzonitrile
Purity: 95+%
Packaging: 5g
Price: $30
Updated: 2021/12/16

Matrix Scientific

Product number: 072472
Product name: 4-Bromo-2-methoxybenzonitrile
Purity: 95+%
Packaging: 10g
Price: $46
Updated: 2021/12/16

Apolloscientific

Product number: OR907624
Product name: 4-Bromo-2-methoxybenzonitrile
Purity: 97%
Packaging: 25g
Price: $99
Updated: 2021/12/16

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4-BROMO-2-METHOXY-BENZONITRILE Chemical Properties,Usage,Production

Uses

4-Bromo-2-methoxybenzonitrile is a useful intermediate for organic synthesis.

Synthesis

67-56-1

105942-08-3

330793-38-9

General procedure for the synthesis of 2-methoxy-4-bromobenzonitrile from methanol and 4-bromo-2-fluorobenzonitrile: 4-bromo-2-fluorobenzonitrile (15.0 g, 75.0 mmol), methanol (30.4 mL, 350 mmol), and potassium carbonate (31.1 g, 225 mmol) were dissolved in N,N-dimethylformamide (DMF, 150 mL) and the reaction was stirred overnight at 55°C under argon protection. The reaction was stirred at 55°C overnight under argon protection. Upon completion of the reaction, thin layer chromatography (TLC, spreading agent 100% dichloromethane) showed complete consumption of the material. The reaction mixture was poured into a mixture of ether (300 mL) and water (150 mL) and the organic layer was separated. The organic layer was washed sequentially with water (150 mL) and brine (50 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 2-methoxy-4-bromobenzonitrile (15.2 g, 95.5% yield) as a white solid. The structure of the product was confirmed by hydrogen nuclear magnetic resonance (1H-NMR, CDCl3) and gas chromatography (GC-MS): 1H-NMR (CDCl3) δ 7.41 (d, J = 8.1 Hz, 1H), 7.16 (dd, J = 8.1, 1.6 Hz, 1H), 7.13 (d, J = 1.6 Hz, 1H), 3.93 (s, 3H); GC- MS m/z = 211 (M+), retention time (RT) = 6.15 min.

References

[1] Patent: WO2005/14566, 2005, A1. Location in patent: Page/Page column 60
[2] Patent: WO2009/7747, 2009, A2. Location in patent: Page/Page column 43
[3] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 57
[4] Patent: WO2008/25509, 2008, A1. Location in patent: Page/Page column 91-92

4-BROMO-2-METHOXY-BENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMO-2-METHOXY-BENZONITRILE Suppliers

China 132 Germany 1 India 3 Switzerland 1 United Kingdom 2 United States 16 Global 155

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330793-38-9, 4-BROMO-2-METHOXY-BENZONITRILERelated Search:

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4-BROMO-2-METHOXY-BENZONITRILE

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330793-38-9

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