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Clobetasone butyrate

Product Name
Clobetasone butyrate
CAS No.
25122-57-0
Chemical Name
Clobetasone butyrate
Synonyms
eumovate;Clobetasone-17-butyrate;sn203;Emovate;molivate;CCl 5537;GR 2/1214;Kindavate;(16-beta)-);17-Butyrate
CBNumber
CB0497976
Molecular Formula
C26H32ClFO5
Formula Weight
478.98
MOL File
25122-57-0.mol
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Clobetasone butyrate Property

Melting point:
90-100°
Boiling point:
573.3±50.0 °C(Predicted)
Density 
1.1736 (estimate)
storage temp. 
Refrigerator, Under Inert Atmosphere
solubility 
Practically insoluble in water, freely soluble in acetone and in methylene chloride, slightly soluble in ethanol (96 per cent).
color 
White to Off-White
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
FBRAWBYQGRLCEK-JGSYYNBSNA-N
SMILES
[C@]1(C(=O)CCl)(OC(=O)CCC)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]12C |&1:0,11,14,16,26,28,33,r|
CAS DataBase Reference
25122-57-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
40
Safety Statements 
22-36
WGK Germany 
3
RTECS 
TU4154083
HS Code 
29372290
Toxicity
mouse,LD50,intraperitoneal,500mg/kg (500mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 838, 1983.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C5548
Product name
Clobetasone butyrate
Purity
≥98%
Packaging
100mg
Price
$61.9
Updated
2024/03/01
Sigma-Aldrich
Product number
C2285000
Product name
Clobetasone butyrate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
c2285000
Price
$153
Updated
2024/03/01
TCI Chemical
Product number
C3510
Product name
Clobetasone Butyrate
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
C3510
Product name
Clobetasone Butyrate
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$194
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001137
Product name
Clobetasone butyrate for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001137
Price
$150
Updated
2024/03/01
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Clobetasone butyrate Chemical Properties,Usage,Production

Chemical Properties

White or almost white powder.

Uses

Clobetasone butyrate is a synthetic glucocorticoid which is used as an anti-inflammatory in the treatment of various skin disorders. As a steroid medicine, it can used on the skin to treat swelling, itching and irritation. Such as eczema, including ;contact dermatitis; psoriasis; insect bites and stings; nappy rash.

Definition

ChEBI: Clobetasone butyrate is an organic molecular entity.

Mechanism of action

Topical corticosteroids (Clobetasone butyrate) inhibit the migration of macrophages and leukocytes into areas of inflamed skin by reversing vascular dilation and permeability, resulting in decreased erythema, edema and pruritus.

Side effects

Some people get a burning or stinging feeling for a few minutes when they put clobetasone cream or ointment on their skin. Clobetasone cream contains cetostearyl alcohol and chlorocresol, which may cause local skin reactions or allergic reactions.

Clobetasone butyrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Clobetasone butyrate Suppliers

Americas 1 Canada 1 China 120 Europe 3 Germany 1 India 19 Japan 1 Switzerland 1 United Kingdom 2 United States 18 Global 167
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View Lastest Price from Clobetasone butyrate manufacturers

Henan Bao Enluo International TradeCo.，LTD
Product
Clobetasone butyrate 25122-57-0
Price
US $100.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-07-19
Hebei Mojin Biotechnology Co., Ltd
Product
Clobetasone butyrate 25122-57-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-06
Anhui Ruihan Technology Co., Ltd
Product
Clobetasone butyrate 25122-57-0
Price
US $25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100tons
Release date
2023-08-22

25122-57-0, Clobetasone butyrateRelated Search:

Tributyrin Hexyl butyrate Butyric Acid Clobetasol Sodium Butyrate Isoamyl butyrate Epichlorohydrin Chloromethyl butyrate Clobetasol propionate CHLOROPHOSPHONAZO III Ethanone, 2-chloro-1-cyclopentyl- (9CI) 2-FLUOROCYCLOHEXANONE 1-Chlorohexadecane METHOXYMELONAL FEMA 3332 Clobetasone Chloroacetic acid 1-ACETOXY-3-CHLOROACETONE

  • )-pregn-5-en-20-one
  • 3,17-Dihydroxy-16-methyl-(3&beta
  • )-3,17-Dihydroxy-2-(1-piperidinyl)androstan-16-yl]-1-methyl|piperidinium Bromide
  • )-16-Methyl-17,20:20,21-bis[methylenebis(oxy)]-pregna-1,4-diene-3,11-dione
  • )-3-(Acetyloxy)-17-hydroxy-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium Bromide-d3
  • -Hydroxytestosterone
  • )-11-Hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
  • )-17-Acetyloxy-3-hydroxy-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium Bromide
  • )-16-Methyl-17,21-bis(1-oxopropoxy)pregna-1,4,9(11)-triene-3,20-dione
  • 20R)-9-Fluoro-11,20-dihydroxy-16-methyl-3-oxopregna-1,4-dien-21-oic Acid|(Betamethasone Impurity)
  • )-3-(Acetyloxy)-17-hydroxy-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium Bromide
  • -Hydroxy Stanozolol
  • (16-beta)-)
  • 11,20-trione,21-chloro-9-fluoro-17-hydroxy-16-beta-methyl-pregna-4-diene-3
  • 21-chloro-9-fluoro-17-hydroxy-16-beta-methylpregna-1,4-diene,3,11,20-trione
  • eumovate
  • molivate
  • pregna-1,4-diene-3,11,20-trione,21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy
  • sn203
  • 21-chloro-9-fluoro-17-hydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione 17-butyrate
  • ClobetasolPropionate-Bp/Ep/Usp
  • Butyric acid, ester with 21-chloro-9-fluoro-17-hydroxy-16β-methylpregna-1,4-diene-3,11,20-trione (8CI)
  • CCl 5537
  • Emovate
  • GR 2/1214
  • Kindavate
  • Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-16-methyl-17-(1-oxobutoxy)-, (16β)-
  • Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-17-hydroxy-16β-methyl-, butyrate (8CI)
  • 21-Chloro-9-fluoro-17-hydroxy-16b-methylpregna-1,4-diene-3,11,20-trione 17-butyrate
  • Clobetasone butyrate
  • Clobetasone-17-butyrate
  • H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione|(Deflazacort Impurity)
  • )-9-Fluoro-11,17,21-trihydroxy-16-methylpregn-4-ene-3,20-dione
  • )-17,21-Bis(acetyloxy)-16-methyl-pregna-1,4,9(11)-triene-3,20-dione
  • -Hydroxy-17-epi-norethisterone
  • H-Pregna-1,4-dieno[17,16-d]oxazole-3,11,20-trione
  • -Hydroxymestanolone
  • )-6-Bromo-9-fluoro-11,17-dihydroxy-16-methyl-21-[(1-oxopentyl)oxy]-pregna-1,4-diene-3,20-dione
  • CLOBETASOLE BUTYRATE
  • 21-Chloro-9-fluoro-16β-methyl-17-(1-oxobutoxy)pregna-1,4-diene-3,11,20-trione
  • 21-Chloro-9-fluoro-17-hydroxy-16β-methylpregna-1,4-diene-3,11,20-trione=butyrate
  • [(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] butanoate
  • [(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroethanoyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] butanoate
  • butyric acid [(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-3,11-diketo-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-yl] ester
  • 17-Butyrate
  • Clonazepam impurity B CRS
  • Clobetasone butyrate for system suitability CRS
  • Clobetasone butyrate CRS
  • Clobetasone butyrate solution in Acetonitrile，100μg/mL
  • Clobetasone ButyrateQ: What is Clobetasone Butyrate Q: What is the CAS Number of Clobetasone Butyrate Q: What is the storage condition of Clobetasone Butyrate
  • 4-(methylamino)-3-nitro-
  • 21-chloro-9-fluoro-16β-methyl-3,11,20-trioxopregna-1,4-dien-17-ylbutanoate
  • Simvastatin Impurity 44
  • 25122-57-0
  • C26H32ClFO5
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids