ChemicalBook > CAS DataBase List > DK-AH 269

DK-AH 269

Product Name
DK-AH 269
CAS No.
186097-54-1
Chemical Name
DK-AH 269
Synonyms
Cilobradine DK-AH;DK-AH 269;DKAH-269;Cilobradine (DK-AH 269;Cilobradine (hydrochloride);DK-AH 269 >=98% (HPLC), solid;(S)-3-((1-(3,4-Dimethoxyphenethyl)piperidin-3-yl)methyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride;(S)-(+)-7,8-Dimethoxy-3-[[1-(2-(3,4-dimethoxyphenyl)ethyl)-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride;Cilobradine hydrochloride, (S)-(+)-7,8-Dimethoxy-3-[[1-(2-(3,4-dimethoxyphenyl)ethyl)-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
CBNumber
CB0498054
Molecular Formula
C28H38N2O5.ClH
Formula Weight
519.078
MOL File
186097-54-1.mol
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DK-AH 269 Property

storage temp. 
2-8°C
solubility 
H2O: ~20 mg/mL
form 
solid
color 
white
Water Solubility 
H2O: ~20mg/mL
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D6942
Product name
DK-AH 269
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$222
Updated
2025/07/31
Sigma-Aldrich
Product number
D6942
Product name
DK-AH 269
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$420
Updated
2025/07/31
Cayman Chemical
Product number
21425
Product name
DK-AH 269
Purity
≥98%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
21425
Product name
DK-AH 269
Purity
≥98%
Packaging
5mg
Price
$168
Updated
2024/03/01
Cayman Chemical
Product number
21425
Product name
DK-AH 269
Purity
≥98%
Packaging
10mg
Price
$315
Updated
2024/03/01
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DK-AH 269 Chemical Properties,Usage,Production

Uses

DK-AH 269 has been used as a hyperpolarization-activated and cyclic nucleotide-gated channel (HCN) antagonist to study its effects on the inhibition of Ih?in?HCN-deficient hair cells of mice. It has also been used as an HCN blocker to study its effects on action potential firing in the suprachiasmatic nucleus (SCN) neurons.

Biochem/physiol Actions

DK-AH 269 is a bradycardiac agent.

in vivo

Cilobradine (4-40 mg/kg; s.c,; single dose) hydrochloride can prolong the latency of the a-wave or b-wave of the rat electroretinogram (ERG), and a dose-dependent waveform change after the b-wave occurs at a specific light stimulus brightness[4].
. Cilobradine (intracerebroventricular injection dose 0.6 μg; intraperitoneal injection dose 20 mg/kg; intracerebroventricular microinjection and i.p.; single dose) hydrochloride can reverse depressive-like behavior, and the effect lasts for about two weeks[5].

Animal Model:Male C57BL/6J mice (8-15 weeks old), chronic social defeat stress (CSDS) model[5]
Dosage:Intra-VTA injection 0.6 μg, intraperitoneal injection 20 mg/kg
Administration:Intra-VTA micro- infusion or intraperitoneal injection, single
Result:Reversed depressive-like behaviors within 1 h and the effect lasted for about two weeks.
Increased time in social interaction and reduced time in the corner zone.
Increased sucrose preference and reduced immobility time in the forced swim test.

DK-AH 269 Preparation Products And Raw materials

Raw materials

Preparation Products

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DK-AH 269 Suppliers

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186097-54-1, DK-AH 269Related Search:

Pyridine hydrochloride Trimethylamine hydrochloride Triethylamine hydrochloride Methylamine hydrochloride

  • Cilobradine (DK-AH 269
  • DK-AH 269;DKAH-269
  • Cilobradine (hydrochloride)
  • Cilobradine hydrochloride, (S)-(+)-7,8-Dimethoxy-3-[[1-(2-(3,4-dimethoxyphenyl)ethyl)-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
  • Cilobradine DK-AH
  • (S)-(+)-7,8-Dimethoxy-3-[[1-(2-(3,4-dimethoxyphenyl)ethyl)-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride
  • DK-AH 269 >=98% (HPLC), solid
  • (S)-3-((1-(3,4-Dimethoxyphenethyl)piperidin-3-yl)methyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride
  • 186097-54-1
  • C28H38N2O5HCl