MPEP HYDROCHLORIDE
- Product Name
- MPEP HYDROCHLORIDE
- CAS No.
- 219911-35-0
- Chemical Name
- MPEP HYDROCHLORIDE
- Synonyms
- NSC1876;NSC-1876;NSC 1876;MPEP Hydrochloride, >98%;MPEP hydrochloride, 10 mM in DMSO;6-methyl-2-(phenylethynyl)pyridine;MPEP hydrochloride (DMSO Solution);MPEP hydrochloride, mGlu5 antagonist;Pyridine, 6-methyl-2-(phenylethynyl)-;2-methyl-6-(phenylethynyl)pyridine(MPEP)
- CBNumber
- CB0498261
- Molecular Formula
- C14H11N.ClH
- Formula Weight
- 229.709
- MOL File
- 219911-35-0.mol
MPEP HYDROCHLORIDE Property
- Melting point:
- 145-146℃
- storage temp.
- room temp
- solubility
- DMSO: 10 mg/mL
- form
- solid
- color
- off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
- InChIKey
- PKDHDJBNEKXCBI-UHFFFAOYSA-N
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H320Causes eye irritation
H336May cause drowsiness or dizziness
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M5435
- Product name
- 6-Methyl-2-(phenylethynyl)pyridine hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $118
- Updated
- 2025/07/31
- Product number
- M5435
- Product name
- 6-Methyl-2-(phenylethynyl)pyridine hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $398
- Updated
- 2025/07/31
- Product number
- 14536
- Product name
- MPEP (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 14536
- Product name
- MPEP (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $82
- Updated
- 2024/03/01
- Product number
- 14536
- Product name
- MPEP (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $190
- Updated
- 2024/03/01
MPEP HYDROCHLORIDE Chemical Properties,Usage,Production
Description
Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-
Uses
Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7 and 8) inhibit adenylyl cyclase. MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 μM. MPEP is centrally active following systemic administration in vivo, inducing anxiolytic-like effects in rodent models of anxiety and depression when administered at 1-30 mg/kg. MPEP has also been reported as a positive allosteric modulator of mGluR4 at μM concentrations.
Uses
MPEP is a potent and highly selective non-competitive mGlu5a receptor antagonist (1,2). It is also a positive allosteric modulator at mGlu4 receptors.MPEP exhibits anxiolytic and antidepressant properties that may be applicable for treating schizophrenia (3).
Definition
ChEBI: A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
General Description
GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) codes for N-methyl d-aspartate receptor subtype 2B (GluN2B). It belongs to the N-methyl-D-aspartate receptor (NMDAR) gene family. It is located on chromosome 12p13.1.
Biochem/physiol Actions
GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) plays an important role in the growth of neurons and is highly essential for learning and memory. GRIN2B mutation is associated with neuropsychiatric and developmental disorders like schizophrenia, Parkinson′s disease and bipolar disorder. MPEP (2-methyl-6-(phenylethynyl)pyridine?hydrochloride) is used to treat Alzheimer′s disease (AD).
in vitro
in recombinant expressed cells human mglu5a receptor, mpep inhibited quisqualate-stimulated phosphoinositide hydrolysis completely with an ic50 value of 36 nm whereas with no agonist or antagonist activities at cells expressing the human mglu1b receptor. mpep did not show agonist or antagonist activity on human mglu2, -3, -4a, -7b, and -8a receptors [1].
in vivo
in rat neonatal brain slices, mpep inhibited dhpg-stimulated phosphoinositide hydrolysis with a potency and selectivity similar to that observed on human mglu receptors. moreover, in extracellular recordings in the hippocampus ca1 area of anesthetized rats, the microiontophoretic application of dhpg induced neuronal firing that was blocked when mpep was administered [1].
IC 50
36 nm
storage
+4°C (desiccate)
References
[1] FABRIZIO GASPARINI . 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist[J]. Neuropharmacology, 1999, 38 10: Pages 1493-1503. DOI:10.1016/s0028-3908(99)00082-9
[2] JESPER MOSOLFF MATHIESEN. Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP[J]. British Journal of Pharmacology, 2009, 138 6: 1026-1030. DOI:10.1038/sj.bjp.0705159
[3] NICOLAS MORIN . Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys[J]. Neuropharmacology, 2010, 58 7: Pages 981-986. DOI:10.1016/j.neuropharm.2009.12.024
[4] NICOLAS MORIN . MPEP, an mGlu5 receptor antagonist, reduces the development of l-DOPA-induced motor complications in de novo parkinsonian monkeys: Biochemical correlates[J]. Neuropharmacology, 2013, 66: Pages 355-364. DOI:10.1016/j.neuropharm.2012.07.036
[5] AUBIN MICHALON. Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.[J]. Neuron, 2012, 74 1: 49-56. DOI:10.1016/j.neuron.2012.03.009
[6] YOAN MIHOV G H. Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window.[J]. International Journal of Neuropsychopharmacology, 2016, 19 1. DOI:10.1093/ijnp/pyw002
MPEP HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
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View Lastest Price from MPEP HYDROCHLORIDE manufacturers
- Product
- MPEP HYDROCHLORIDE 219911-35-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02
- Product
- MPEP hydrochloride/219911-35-0/99% purity with low price in stock 219911-35-0
- Price
- US $1.00/kg
- Min. Order
- 1 KG
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2019-03-26