ChemicalBook > CAS DataBase List > TYROPANOATE SODIUM

TYROPANOATE SODIUM

Product Name
TYROPANOATE SODIUM
CAS No.
7246-21-1
Chemical Name
TYROPANOATE SODIUM
Synonyms
bilopac;tyropaque;bilopaque;lumopaque;Win 8851-2;nsc-107434;Tyropanic acid;tyropanoatesodium;sodiumtyropanoate;KTVKGXZZBQCBGD-UHFFFAOYSA-M
CBNumber
CB0500555
Molecular Formula
C9H14NNaO2
Formula Weight
191.20273
MOL File
7246-21-1.mol
More
Less

TYROPANOATE SODIUM Property

Melting point:
208-210°
storage temp. 
Refrigerator
solubility 
Methanol (Slightly)
form 
Solid
color 
Off-White to Pale Pink
More
Less

Safety

Toxicity
LD50 i.v. in mice: 720 mg/kg (Hoppe)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
T947900
Product name
TyropanoateSodium
Packaging
500mg
Price
$810
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
42570
Product name
TyropanoateSodium
Packaging
1g
Price
$2200
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0142280
Product name
SODIUM TYROPANOATE
Purity
95.00%
Packaging
5MG
Price
$500.15
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
42570
Product name
TyropanoateSodium
Packaging
100mg
Price
$650
Updated
2021/12/16
More
Less

TYROPANOATE SODIUM Chemical Properties,Usage,Production

Originator

Bilopaque,Winthrop,US,1972

Uses

Tyropanoate Sodium is used for radiographic analysis of the gallbladder via oral cholecystography. Iodinated contrast agent.

Definition

ChEBI: Tyropanoate sodium is a member of benzenes and a monocarboxylic acid.

Manufacturing Process

A solution of 5.0 g of α-ethyl-β-(aminophenyl)propionic acid in 100 ml of water containing 5 ml of concentrated hydrochloric acid was added over a period of ? hour to a stirred solution of 3.2 ml of iodine monochloride in 25 ml of water and 25 ml of concentrated hydrochloric acid heated to 60°C. After addition was complete, the heating was continued for ? hour longer at 60° to 70°C. A black oil separated which gradually solidified. The mixture was then cooled and sodium bisulfite was added to decolorize. Recrystallization of the product from methanol gave about 8 g of α-ethyl-β-(2,4,6-triiodo-3- aminophenyl)-propionic acid, MP 147° to 150°C. The product could be further purified by precipitation of its morpholine salt from ether solution and regeneration of the free amino acid by treatment of a methanol solution of the morpholine salt with sulfur dioxide. The pure amino acid had the MP 155° to 156.5°C (corr).
A mixture of 57.1 g (0.1 mol) of α-ethyl-β-(3-amino-2,4,6- triiodophenyl)propionic acid, 250 ml of butyric anhydride and 1 ml of 70% perchloric acid was heated at 105°C for 5 hours. After cooling, the reaction mixture was poured onto ice, diluted to a volume of 3 liters with water, and heated on a steam bath with addition of solid sodium carbonate to keep the mixture basic. After all the excess butyric anhydride had been hydrolyzed, the mixture was made acid with dilute hydrochloric acid, the aqueous layer decanted from the resulting gummy solid, and the latter was then washed several times with water. The product was dissolved in acetic acid, decolorized with activated charcoal, and the solution while hot diluted with water to the point of turbidity. The product was collected by filtration and dried, giving 40 g of α-ethyl-β-(3-dibutyramido-2,4,6-triiodophenyl)propionic acid, MP 166° to 169.5°C (corr.) when recrystallized from acetic acid. Reaction with sodium hydroxide gives the final product.

brand name

Bilopaque (GE Healthcare).

Therapeutic Function

Diagnostic aid (radiopaque medium)

TYROPANOATE SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

7246-21-1, TYROPANOATE SODIUM Related Search:


  • TYROPANOATE SODIUM (500 MG)
  • 3-butyramido-alpha-ethyl-2,4,6-triiodohydrocinnamicacidsodiumsalt
  • sodiumtyropanoate
  • tyropanoatesodium
  • tyropaque
  • tyropanoic acid sodium salt
  • 3-Butyrylamino-α-ethyl-2,4,6-triiodohydrocinnamic acid sodium
  • Win 8851-2
  • KTVKGXZZBQCBGD-UHFFFAOYSA-M
  • 3-butyramido-alpha-ethyl-2,4,6-triiodo-hydrocinnamicacisodiumsalt
  • alpha-ethyl-2,4,6-triiodo-3-((1-oxobutyl)amino)-benzenepropanoicacimono
  • alpha-ethyl-beta-(2,4,6-triiodo-3-butyramidophenyl)propionicacidsodiumsalt
  • bilopac
  • bilopaque
  • lumopaque
  • nsc-107434
  • sodium3-butyramido-alpha-ethyl-2,4,6-triiodohydrocinnamate
  • Tyropanic acid
  • sodium,2-[[3-(butanoylamino)-2,4,6-triiodophenyl]methyl]butanoate
  • 7246-21-1
  • C15H17I3NNaO3