Iopanoic acid
- Product Name
- Iopanoic acid
- CAS No.
- 96-83-3
- Chemical Name
- Iopanoic acid
- Synonyms
- colepax;win2011;Bilipac;cistobil;cholevid;COPANOIC;Iopanoic;Bilumbal;choladine;bilijodon
- CBNumber
- CB0753539
- Molecular Formula
- C11H12I3NO2
- Formula Weight
- 570.93
- MOL File
- 96-83-3.mol
Iopanoic acid Property
- Melting point:
- 153 °C
- Boiling point:
- 529.1±50.0 °C(Predicted)
- Density
- 2.2567 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO, Methanol
- form
- Solid
- pka
- 4.8(at 25℃)
- color
- Light Brown
- Water Solubility
- 348.3mg/L(37 ºC)
- Merck
- 14,5058
- BCS Class
- 2
- CAS DataBase Reference
- 96-83-3(CAS DataBase Reference)
- EPA Substance Registry System
- Benzenepropanoic acid, 3-amino-.alpha.-ethyl-2,4,6-triiodo- (96-83-3)
Safety
- Risk Statements
- 20/21/22
- Safety Statements
- 22-26-36/37/39
- WGK Germany
- 1
- RTECS
- NW5075000
- HS Code
- 2922.49.3700
- Hazardous Substances Data
- 96-83-3(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I0330000
- Product name
- Iopanoic acid
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- i0330000
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 14131
- Product name
- Iopanoic acid
- Purity
- analytical standard
- Packaging
- 100mg
- Price
- $78.4
- Updated
- 2021/12/16
- Product number
- I0300
- Product name
- Iopanoic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $209
- Updated
- 2024/03/01
- Product number
- I0300
- Product name
- Iopanoic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $840
- Updated
- 2024/03/01
- Product number
- I717400
- Product name
- IodopanoicAcid
- Packaging
- 10g
- Price
- $990
- Updated
- 2021/12/16
Iopanoic acid Chemical Properties,Usage,Production
Chemical Properties
Light Brown Solid
Originator
Telepaque,Winthrop,US,1952
Uses
antiulcer
Uses
Iodopanoic Acid is an iodine-containing radiocontrast medium used in cholecystography. Iodopanoic Acid is a potent inhibitor of thyroid hormone release from thyroid gland.
Definition
ChEBI: Iopanoic acid is a monocarboxylic acid.
Manufacturing Process
(A) Preparation of α-Ethyl-m-Nitrocinnamic Acid: This acid is prepared from
100 g of m-nitrobenzaldehyde, 210 g of butyric anhydride and 73 g of sodium
butyrate. The crude α-ethyl-m-nitrocinnamicacid is crystallized from ethanol
giving about 105 g, MP 140° to 142°C. From the filtrates there may be
isolated a small amount of a stereoisomer, which when pure melts at 105° to
106°C.
(B) Preparation of m-Amino-α-Ethylhydrocinnamic Acid: A mixture of 50 g of
α-ethyl-m-nitrocinnamic acid, 9.1 g of sodium hydroxide, 600 cc of water and
5 teaspoons of Raney nickel catalyst is shaken at 32°C in an atmosphere ofhydrogen at an initial pressure of 450 psi until the calculated amount of
hydrogen is absorbed. The filtered solution is acidified with hydrochloric acid,
made basic with ammonium hydroxide and again acidified with acetic acid.
Upon concentration of this solution, an oil separates which crystallizes upon
standing, giving about 20 g, MP 60° to 68°C. Complete evaporation of the
filtrate and extraction of the residue of inorganic salts with ether gives about
20 g of additional material, MP 54° to 59°C. Recrystallization of the combined
product from benzene petroleum ether gives about 35 g of m-amino-α-
ethylhydrocinnamic acid, MP 67° to 70°C.
(C) Preparation of β-(3-Amino-2,4,6-Triiodophenyll-α-Ethylpropionic Acid: A
solution of 5.0 g of m-amino-α-ethylhydrocinnamic acid in 100 cc of water
containing 5 cc of concentrated hydrochloric acid is added over a period of ?
hour to a stirred solution of 3.2 cc of iodine monochloride in 25 cc of water
and 25 cc of concentrated hydrochloric acid heated to 60°C. After addition is
complete, the heating is continued for one hour longer at 60° to 70°C. A black
oil separates which gradually solidifies.
The mixture is then cooled and sodium bisulfite added to decolorize.
Recrystallization of the product from methanol gives about 8 g, MP 147° to
150°C. The β-(3-amino-2,4,6-triiodophenyl)-α-ethylpropionic acid may be
purified further by precipitation of the morpholine salt from ether solution and
regeneration of the free amino acid by treatment of a methanol solution of the
morpholine salt with sulfur dioxide. The pure amino acid has the MP 155° to
156.5°C.
Therapeutic Function
Diagnostic aid (radiopaque medium)
Iopanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Iopanoic acid Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94657
- Advantage
- 76
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 847-367-3680
- Fax
- 847-367-3681
- sales@arkpharminc.com
- Country
- United States
- ProdList
- 1670
- Advantage
- 56
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44689
- Advantage
- 61
- Tel
- 1-(800)-881-8210
- Fax
- 615-250-9817
- inquiries@lgmpharma.com
- Country
- United States
- ProdList
- 2123
- Advantage
- 70
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from Iopanoic acid manufacturers
- Product
- Iopanoic acid 96-83-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Iopanoic acidv 96-83-3
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2019-12-31