(Diacetoxyiodo)benzene
- Product Name
- (Diacetoxyiodo)benzene
- CAS No.
- 3240-34-4
- Chemical Name
- (Diacetoxyiodo)benzene
- Synonyms
- PhI(OAc)2;BAIB;IODOBENZENE DIACETATE;DAIB;[Bis(acetoxy)iodo]benzene;PIA;PHENYLIODINE DIACETATE;IODOSOBENZENE DIACETATE;Phenyliodoso diacetate;IODOBENZENE I,I-DIACETATE
- CBNumber
- CB2222138
- Molecular Formula
- C10H11IO4
- Formula Weight
- 322.1
- MOL File
- 3240-34-4.mol
(Diacetoxyiodo)benzene Property
- Melting point:
- 161-163 °C (lit.)
- Density
- 1.6865 (estimate)
- refractive index
- n/D 1.444
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- INSOLUBLE
- form
- Solution
- color
- Clear to cloudy colorless to yellow
- biological source
- mouse
- Water Solubility
- INSOLUBLE
- Sensitive
- Light Sensitive
- BRN
- 1879369
- Stability:
- Light and Moisture sensitive
- InChIKey
- ZBIKORITPGTTGI-UHFFFAOYSA-N
- CAS DataBase Reference
- 3240-34-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Iodobenzene diacetate(3240-34-4)
- EPA Substance Registry System
- Iodine, bis(acetato-.kappa.O)phenyl- (3240-34-4)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-37/39-26-36/37/39-27
- RIDADR
- 1479
- WGK Germany
- 3
- RTECS
- DA3525000
- F
- 4.10-8
- Hazard Note
- Irritant
- TSCA
- Yes
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29310095
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 178721
- Product name
- (Diacetoxyiodo)benzene
- Purity
- 98%
- Packaging
- 5g
- Price
- $26
- Updated
- 2025/07/31
- Product number
- 178721
- Product name
- (Diacetoxyiodo)benzene
- Purity
- 98%
- Packaging
- 25g
- Price
- $71.5
- Updated
- 2025/07/31
- Product number
- WH0253260M1
- Product name
- Monoclonal Anti-RICTOR antibody produced in mouse
- Purity
- clone 1F3, purified immunoglobulin, buffered aqueous solution
- Packaging
- 100 μg
- Price
- $406
- Updated
- 2025/07/31
- Product number
- SAB5300210
- Product name
- Monoclonal Anti-RICTOR antibody produced in mouse
- Purity
- clone 7B3, ascites fluid
- Packaging
- 100 μL
- Price
- $541
- Updated
- 2025/07/31
- Product number
- I0330
- Product name
- Iodobenzene Diacetate
- Purity
- >97.0%(T)
- Packaging
- 10g
- Price
- $27
- Updated
- 2025/07/31
(Diacetoxyiodo)benzene Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
(Diacetoxyiodo)benzene is a hypervalent iodine reagent that is used in conjunction with catalytic amount of sodium azide in acetonitrile, which enables oxidative decarboxylation of 2-aryl carboxylic acid into the corresponding aldehydes, ketones and nitriles.
Application
(Diacetoxyiodo)benzene, an oxidizing agent, has a wide range of applications. (Diacetoxyiodo)benzene, also known as Diacetoxy Iodobenzene, is used in wide range of medicals industrial applications as well as in human and animal nutrition products such as antiseptics and disinfectants, pharmaceutical intermediates, polarizing films for liquid crystal display [LCD] chemicals.
Origin
This reagent was originally prepared by Conrad Willgerod by reacting iodobenzene with a mixture of acetic acid and peracetic acid：
C6H5I + CH3CO3H + CH3CO2H → C6H5I(O2CCH3)2 + H2O
reaction suitability
reagent type: catalyst
reagent type: oxidant
reaction type: C-H Activation
Biological Activity
RPTOR independent companion of MTOR complex 2 (RICTOR) maintains stability of the mechanistic target of rapamycin (mTOR) complex 2. It also has a role in neutrophil chemotaxis and has been linked to prostate cancer.
Synthesis
591-50-4
75-07-0
3240-34-4
GENERAL STEPS: In a typical experiment, glacial acetic acid (2 mL), iodobenzene (0.401 mmol), and cobalt chloride hexahydrate (0.004 mmol, 1 mol%) were added to a 20 mL scintillation vial and a rubber septum was assembled. The reaction vessel was purged with oxygen for 5 min, and then acetaldehyde (4.07 mmol, 10.2 eq.) was added all at once. The reaction mixture was stirred at 1 atmosphere of oxygen and reacted at 23°C for 5 h via an inflated balloon. After completion of the reaction, the solvent was removed under vacuum and the residue was dissolved in dichloromethane. The organic layer was washed with distilled water and extracted with dichloromethane (3 x 7 mL). The organic layers were combined, dried with anhydrous magnesium sulfate and the solvent was removed in vacuum to give iodobenzene diacetic acid. The isolated compounds were characterized by 1H NMR and 13C NMR spectroscopy.
Purification Methods
The purity of diacetoxyiodobenzene can be checked by treatment with H2SO4 then KI and the liberated I2 is estimated with standard thiosulfate. It has been recrystallised from 5M acetic acid and dried overnight in a vacuum desiccator over CaCl2. The surface of the crystals may become slightly yellow but this does not affect its usefulness. [Sharefkin & Saltzman Org Synth Coll Vol V 600 1973, Beilstein 5 IV 693.]
References
[1] Nature Chemistry, 2018, vol. 10, # 2, p. 200 - 204
(Diacetoxyiodo)benzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (Diacetoxyiodo)benzene manufacturers
- Product
- (Diacetoxyiodo)benzene 3240-34-4
- Price
- US $1.50/g
- Min. Order
- 1g
- Purity
- 99.0% Min
- Supply Ability
- 10 Tons
- Release date
- 2025-06-25
- Product
- (Diacetoxyiodo)benzene 3240-34-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-22
- Product
- Iodobenzene diacetate 3240-34-4
- Price
- US $50.00-80.00/kg
- Min. Order
- 100kg
- Purity
- 99%
- Supply Ability
- 200mt
- Release date
- 2019-03-15