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Astragaloside IV

Product Name
Astragaloside IV
CAS No.
83207-58-3
Chemical Name
Astragaloside IV
Synonyms
Astragaloside IV;Astramembrannin i;Astragalin A;astragaloside A;Astragaloside IV;Astragaloside A 5%;ASTRAGALOSIDE IV(P);Astragaloside IV(A);Astragaloside IV CRS;Astragaloside IV ,98%
CBNumber
CB0500944
Molecular Formula
C41H68O14
Formula Weight
784.97
MOL File
83207-58-3.mol
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Astragaloside IV Property

Boiling point:
895.7±65.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
form 
A crystalline solid
pka
12.91±0.70(Predicted)
InChI
InChI=1/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24?,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/s3
InChIKey
QMNWISYXSJWHRY-APZLXCBQNA-N
SMILES
[C@@]123CC[C@]4(C)[C@]([H])([C@@H](O)C[C@@]4(C)[C@]1([H])C[C@H](O[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)[C@@]1([H])C(C)(C)C(O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)CC[C@]21C3)[C@@]1(C)CC[C@@H](C(O)(C)C)O1 |&1:0,3,5,7,10,12,15,17,18,20,21,23,28,35,38,40,42,46,48,52,r|
LogP
0.628 (est)
CAS DataBase Reference
83207-58-3
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Safety

HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16677
Product name
Astragaloside A
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
16677
Product name
Astragaloside A
Purity
≥98%
Packaging
5mg
Price
$233
Updated
2024/03/01
Cayman Chemical
Product number
16677
Product name
Astragaloside A
Purity
≥98%
Packaging
10mg
Price
$412
Updated
2024/03/01
Cayman Chemical
Product number
16677
Product name
Astragaloside A
Purity
≥98%
Packaging
50mg
Price
$1092
Updated
2024/03/01
TRC
Product number
A790125
Product name
AstragalosideA
Packaging
1mg
Price
$45
Updated
2021/12/16
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Astragaloside IV Chemical Properties,Usage,Production

Uses

Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes from apoptosis resulting from ischemia/reperfusion and inhibits inflammation signaled through TNF-α. Furthermore, astragaloside A stimulates angiogenesis, promotes the differentiation of neural stem cells, and increases neuroregeneration.

Definition

ChEBI: A pentacyclic triterpenoid that is cycloastragenol having beta-D-xylopyranosyl and beta-D-glucopyranosyl residues attached at positions O-3 and O-6 respectively. It is isolated from <ital Astragalus membranaceus var mongholicus.

benefits

Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. It is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. Astragaloside IV improves post-ischemic heart function and ameliorated reperfusion arrhythmias accompanied by a significant increase in myocardial antioxidative enzyme superoxide dismutase activity in rat hearts in vitro. While, Astragaloside IV's protective effect on heart function can be partially abrogated by the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methyl ester.

Health effects

As the main active ingredient of the Chinese medicine Astragalus membranaceus, Astragaloside A has a good regulatory effect on the heart. It can protect against ischemic and hypoxic cardiomyocytes, protect the heart structure, and enhance heart function.

Pharmaceutical Applications

Astrageloside A has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, Astragaloside A possesses potential for broad application in many diseases.

Mode of action

Astragaloside IV is a well-known AM compound known for its neuroprotective effects. It acts as an antioxidant and reduces cell inflammation and oxidative stress. Astragaloside IV helps protect dopaminergic neurons and promotes neural process outgrowth, potentially therapeutic in PD. All the benefits of this compound for neurodegenerative diseases such as AD, PD, cerebral ischemia, and autoimmune encephalomyelitis. AS-IV maintains dopamine synthesis by increasing enzymes tyrosine hydroxylase (TH) and nitric oxide synthase (NOS), which are involved in neuron production pathways, neural signalling, and cell immune responses. The other mechanism of AS-IV in PD disease is the prevention of neuron pathology by a neurotoxicant called 1-methyl-4-phenylpyridium ion (MPP+) throughout the increasing cell survival, inhibiting pro-apoptosis Bax-mediated pathway and caspase protein (Caspase-3) activity which can destroy cellular structures while increasing anti-apoptosis B-cell lymphoma 2 (Bcl-2). It also protects neuron mitochondria from apoptosis and DNA damage by inducing Akt to promote binding of hexokinase-II (HK-II) and mitochondria for the protection of neural mitochondria[1].

References

[1] Veit Ny . “Potential benefits of incorporating Astragalus membranaceus into the diet of people undergoing disease treatment: An overview.” Journal of Functional Foods 77 (2021): Article 104339.

Astragaloside IV Preparation Products And Raw materials

Raw materials

Preparation Products

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Astragaloside IV Suppliers

Nanjing Spring & Autumn Biological Engineering Co., Ltd.
Tel
025-84430028 13815430202
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sale02@cqherb.com
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China
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Xi'an Chaobang Biotechnology Co. , Ltd.
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13324615505
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976908044@qq.com
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China
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Jiangsu Yongjian Pharmaceutical Technology Co., Ltd
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17701422015
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3582572959@qq.com
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China
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Nanjing bingcheng Biotechnology Co., Ltd.
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18805194892; 18805194892
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2727751293@qq.com
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China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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China
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XiaoGan ShenYuan ChemPharm co,ltd
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15527768850
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1791901229@qq.com
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China
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China Langchem Inc.
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0086-21-58956006
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0086-21-58956100
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China
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Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
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+86-571-82880190
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info@yuhaochemical.com
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China
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9387
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Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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010-65763397
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waley188@sohu.com
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China
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View Lastest Price from Astragaloside IV manufacturers

Chengdu King-tiger Pharm-chem. Tech. Co., Ltd.
Product
Astragaloside IV 83207-58-3
Price
US $7.00-4600.00/g
Min. Order
10g
Purity
1%-98%
Supply Ability
100
Release date
2024-07-04
BINBO BIOLOGICAL CO.,LTD
Product
Astragaloside A 83207-58-3
Price
US $0.00/kg
Min. Order
1kg
Purity
0.3% 1% 3% 5% 10% 98%
Supply Ability
1000 kg
Release date
2024-12-02
Hebei Kingfiner Technology Development Co.Ltd
Product
Astragaloside A 83207-58-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
50000kg
Release date
2024-06-24

83207-58-3, Astragaloside IVRelated Search:


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  • Astragaloside IV
  • Astragaloside IV ,98%
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  • Astramembrannin i
  • beta-D-Glucopyranoside, (3beta,6alpha,16beta,24R)-20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
  • β-D-Glucopyranoside, (3β,6α,16β,24R)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
  • Astragalus Extract Astragaloside IV
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  • Astragaloside IV CRS
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  • Astragaloside A USP/EP/BP
  • Astragaloside A 5%
  • b-D-Glucopyranoside, (3b,6a,16b,24R)-20,24-epoxy-16,25-dihydroxy-3-(b-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
  • Astragaloside A (Astramembrannin I
  • astragalus polysaccharide concentrated extract
  • Astragalus methylside
  • (2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)hexadecahydrocyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  • Astragaloside IV
  • 83207-58-3
  • Inhibitors
  • API
  • Plant extracts