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Astragaloside A

Product Name
Astragaloside A
CAS No.
83207-58-3
Chemical Name
Astragaloside A
Synonyms
Astragaloside IV;Astramembrannin i;Astragalin A;astragaloside A;Astragaloside A 5%;ASTRAGALOSIDE IV(P);Astragaloside IV(A);Astragaloside IV CRS;Astragaloside IV ,98%;Astragalus methylside
CBNumber
CB0500944
Molecular Formula
C41H68O14
Formula Weight
784.97
MOL File
83207-58-3.mol
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Astragaloside A Property

Boiling point:
895.7±65.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
form 
A crystalline solid
pka
12.91±0.70(Predicted)
InChI
InChI=1/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24?,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/s3
InChIKey
QMNWISYXSJWHRY-APZLXCBQNA-N
SMILES
[C@@]123CC[C@]4(C)[C@]([H])([C@@H](O)C[C@@]4(C)[C@]1([H])C[C@H](O[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)[C@@]1([H])C(C)(C)C(O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)CC[C@]21C3)[C@@]1(C)CC[C@@H](C(O)(C)C)O1 |&1:0,3,5,7,10,12,15,17,18,20,21,23,28,35,38,40,42,46,48,52,r|
LogP
0.628 (est)
CAS DataBase Reference
83207-58-3
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Safety

HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16677
Product name
Astragaloside A
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
16677
Product name
Astragaloside A
Purity
≥98%
Packaging
5mg
Price
$233
Updated
2024/03/01
Cayman Chemical
Product number
16677
Product name
Astragaloside A
Purity
≥98%
Packaging
10mg
Price
$412
Updated
2024/03/01
Cayman Chemical
Product number
16677
Product name
Astragaloside A
Purity
≥98%
Packaging
50mg
Price
$1092
Updated
2024/03/01
TRC
Product number
A790125
Product name
AstragalosideA
Packaging
1mg
Price
$45
Updated
2021/12/16
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Astragaloside A Chemical Properties,Usage,Production

Uses

Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes from apoptosis resulting from ischemia/reperfusion and inhibits inflammation signaled through TNF-α. Furthermore, astragaloside A stimulates angiogenesis, promotes the differentiation of neural stem cells, and increases neuroregeneration.

Definition

ChEBI: A pentacyclic triterpenoid that is cycloastragenol having beta-D-xylopyranosyl and beta-D-glucopyranosyl residues attached at positions O-3 and O-6 respectively. It is isolated from <ital Astragalus membranaceus var mongholicus.

benefits

Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. It is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. Astragaloside IV improves post-ischemic heart function and ameliorated reperfusion arrhythmias accompanied by a significant increase in myocardial antioxidative enzyme superoxide dismutase activity in rat hearts in vitro. While, Astragaloside IV's protective effect on heart function can be partially abrogated by the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methyl ester.

Health effects

As the main active ingredient of the Chinese medicine Astragalus membranaceus, Astragaloside A has a good regulatory effect on the heart. It can protect against ischemic and hypoxic cardiomyocytes, protect the heart structure, and enhance heart function.

Pharmaceutical Applications

Astrageloside A has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, Astragaloside A possesses potential for broad application in many diseases.

Astragaloside A Preparation Products And Raw materials

Raw materials

Preparation Products

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Astragaloside A Suppliers

China 165 India 2 United States 12 Global 179
MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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AdooQ BioScience, LLC
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+1 (866) 333-9607
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Target molecule Corp.
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857-239-0968
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Musechem
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InvivoChem
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BOC Sciences
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inquiry@bocsci.com
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Aladdin Scientific
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+1-833-552-7181
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sales@aladdinsci.com
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TargetMol Chemicals Inc.
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+1-781-999-5354
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support@targetmol.com
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United States
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19973
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View Lastest Price from Astragaloside A manufacturers

Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Astragaloside a ;Astragaloside IV 83207-58-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2024-05-10
Shaanxi Haibo Biotechnology Co., Ltd
Product
Astragaloside A 83207-58-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-22
Henan Fengda Chemical Co., Ltd
Product
Astragaloside A 83207-58-3
Price
US $8.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28

83207-58-3, Astragaloside ARelated Search:

1,1,2,2-TETRAMETHYLCYCLOPROPANE Astragaloside VI AstragalosideⅠ Astragaloside IV,Astragaloside IV,ASTRAGALOSIDE CYCLOPENTADECANE 4-tert-Butylcyclohexanol Menthoxypropanediol CYCLOPENTADECANOL Astragalin Astragaloside II,Astragaloside B,Astragaloside-Ⅱ,ASTRAGALOSIDE II Astragaloside III,Astragaloside-Ⅲ ASTRAGALOSIDE I 2-METHYLPENTACOSANE 1,1-DIETHYLCYCLOPROPANE 2-(TRANS-4'-N-BUTYL-CYCLOHEXYL)PROPANE-1,3-DIOL 2-(TRANS-4-PENTYLCYCLOHEXYL)PROPANE-1,3-DIOL ASTRAGALOSIDE Astragaloside VII ASTRAGALOSIDE I(RG),Astragaloside Ⅳ

  • ASTRAGALOSIDE IV(P)
  • astragaloside A
  • Astragaloside IV
  • Astragaloside IV ,98%
  • Astragaloside IV(A)
  • Astragaloside A(Astragaloside IV)
  • Astramembrannin i
  • beta-D-Glucopyranoside, (3beta,6alpha,16beta,24R)-20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
  • β-D-Glucopyranoside, (3β,6α,16β,24R)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
  • Astragalus Extract Astragaloside IV
  • Astragaloside IV-Astragaloside A
  • Astragaloside IV CRS
  • Astragalin A
  • Astragaloside A USP/EP/BP
  • Astragaloside A 5%
  • b-D-Glucopyranoside, (3b,6a,16b,24R)-20,24-epoxy-16,25-dihydroxy-3-(b-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
  • Astragaloside A (Astramembrannin I
  • astragalus polysaccharide concentrated extract
  • Astragalus methylside
  • (2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)hexadecahydrocyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  • 83207-58-3
  • Inhibitors
  • API
  • Plant extracts