Diethylstilbestrol
- Product Name
- Diethylstilbestrol
- CAS No.
- 6898-97-1
- Chemical Name
- Diethylstilbestrol
- Synonyms
- DES;Diethylstilbestrol;Diethylstillbestrol;3,4-Bis(4-hydroxypheny;Diethylstilbestrol >(E,Z)-Diethylstilbestrol;Diethylstilbestrol-(E,Z);Atovaquone CAS NO.6898-97-1;4-[(Z)-hex-3-en-3-yl]phenol;Diethylstilbestrol USP/EP/BP
- CBNumber
- CB0503501
- Molecular Formula
- C18H20O2
- Formula Weight
- 268.35
- MOL File
- 6898-97-1.mol
Diethylstilbestrol Property
- Melting point:
- 170-172 °C(lit.)
- Boiling point:
- 407.1±25.0 °C(Predicted)
- Density
- 1.107±0.06 g/cm3(Predicted)
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 9.27±0.15(Predicted)
- color
- White to Almost white
- Merck
- 14,3129
- InChIKey
- RGLYKWWBQGJZGM-ISLYRVAYSA-N
- CAS DataBase Reference
- 6898-97-1
Safety
- Hazard Codes
- T,N
- Risk Statements
- 45-61-36/37/38-51/53
- Safety Statements
- 53-36/37/39-45-60-61
- RIDADR
- UN 3077 9/PG 3
- WGK Germany
- 3
- RTECS
- WJ5600000
- HazardClass
- 9
- PackingGroup
- III
- HS Code
- 29072990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H350May cause cancer
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 218944
- Product name
- Diethylstilbestrol, mixture of cis and trans
- Purity
- 97%
- Packaging
- 5g
- Price
- $113
- Updated
- 2023/06/20
- Product number
- D0526
- Product name
- Diethylstilbestrol
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $48
- Updated
- 2024/03/01
- Product number
- D0526
- Product name
- Diethylstilbestrol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $119
- Updated
- 2024/03/01
- Product number
- 446129
- Product name
- Des-
- Packaging
- 2.5mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- 446134
- Product name
- Des-
- Packaging
- 10mg
- Price
- $460
- Updated
- 2021/12/16
Diethylstilbestrol Chemical Properties,Usage,Production
Description
Diethylstilbestrol is a derivative of stilbene, and it differs from sin-estrol by the presence of a double bond with trans-configuration of the two phenyl groups. In terms of estrogenic activity, this drug surpasses both estrone and hexestrol.
Chemical Properties
White solid
Uses
Diethylstilbestrol was used as internal standard for the analysis of drug residues in urine of rats and calves by on-line HPLC with ultraviolet and continuous-flow fast atom bombardmentmass spectrometry detectors.
Definition
ChEBI: Diethylstilbestrol is an olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups. It has a role as an antineoplastic agent, a carcinogenic agent, a xenoestrogen, an EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor, an antifungal agent, an endocrine disruptor, an EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor, an autophagy inducer and a calcium channel blocker. It is a polyphenol and an olefinic compound.
General Description
Mechanisms of the isomerization processes of molecular and anionic diethylstilbestrol (DES) has been reported. Estrogen activity of cis- and trans-diethylstilbestrol has been evaluated. Diethylstilbestrol is a carcinogenic synthetic estrogen.
Synthesis
Diethylstilbestrol, trans-|á,|?-diethyl-4,4-stilbendiol (28.1.34), is proposed to be synthesized in various ways. According to one of them, desoxyansoine is alkylated by ethyl iodide in the presence of sodium ethoxide, and the resulting ketone (28.1.30) is reacted in a Grignard reaction with ethylmagnesium bromide, which forms the carbinol (28.1.31). Dehydration of this compound by distillation in the presence of p-toluenesulfonic acid gives dimethyl ether of stilbestrol (28.1.32), methyl groups of which are removed by heating it at high temperatures with potassium hydroxide, thus forming diethylstilbestrol (28.1.33).
Diethylstilbestrol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Diethylstilbestrol manufacturers
- Product
- Diethylstilbestrol 6898-97-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500
- Release date
- 2023-07-31
- Product
- Diethylstilbestrol 6898-97-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2024-10-11
- Product
- Diethylstilbestrol 6898-97-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26