Doripenem hydrate

ChemicalBook > CAS DataBase List > Doripenem hydrate

Product Name: Doripenem hydrate
CAS No.: 364622-82-2
Chemical Name: Doripenem hydrate
Synonyms: Finibax;2H5]-Doripenem;DoripeneM Crude;doripenem hydrate;S 4661 monohydrate;Doripenem Hydrate (S 4661);Doripenem hydrate USP/EP/BP;Doripenem monohydrate, >=99%;DORIPENEM MONOHYDRATE STERILE;Doripenem Hydrate/Doribax/S-4661/Finibax
CBNumber: CB0511313
Molecular Formula: C15H26N4O7S2
Formula Weight: 438.51
MOL File: 364622-82-2.mol

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Doripenem hydrate Property

Melting point:: 173°C(dec.)(lit.)
storage temp.: 2-8°C
solubility: H2O: soluble5mg/mL, clear (warmed)
form: powder
color: white to beige
PH: Dissolve 0.3g of Doripenem Hydrate in 30mL of water: the pH of the solution is between 4.5 and 6.0.
BRN: 15340136
InChIKey: NTUBEBXBDGKBTJ-WGLOMNHJSA-N
CAS DataBase Reference: 364622-82-2(CAS DataBase Reference)

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Safety

WGK Germany: 3
HS Code: 2935.90.9500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1220
Product name: Doripenem hydrate
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: 32138
Product name: Doripenem monohydrate
Purity: VETRANAL
Packaging: 25mg
Price: $200
Updated: 2024/03/01

TCI Chemical

Product number: D5249
Product name: Doripenem Monohydrate
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $255
Updated: 2024/03/01

TCI Chemical

Product number: D5249
Product name: Doripenem Monohydrate
Purity: >98.0%(HPLC)
Packaging: 250mg
Price: $762
Updated: 2024/03/01

Cayman Chemical

Product number: 16934
Product name: Doripenem (hydrate)
Purity: ≥98%
Packaging: 50mg
Price: $225
Updated: 2021/12/16

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Doripenem hydrate Chemical Properties,Usage,Production

Description

Doripenem hydrate is a carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of infections such as HOSPITAL-ACQUIRED PNEUMONIA, and complicated intra-abdominal or urinary-tract infections, including PYELONEPHRITIS.
Doripenem hydrate was first approved by Pharmaceuticals and Medical Devices Agency of Japan (PMDA) on July 25, 2005, then approved by the U.S. Food and Drug Administration (FDA) on Oct 12, 2007, and approved by European Medicines Agency (EMA) on July 25, 2008. It was developed by Shionogi and Janssen, then marketed as Finibax® in Japan and as Doribax® in the US by Shionogi and as Doribax® by Janssen in BE.

Chemical Properties

Doripenem Hydrate occurs as a white to pale yellow-brown-white crystalline powder. It is sparingly soluble in water, slightly soluble in methanol, and practically insoluble in ethanol (99.5). It is gradually colored to pale yellow-brown-white by light.

Uses

Doripenem monohydrate is a broad spectrum antibiotic belonging to the class of antibiotics called carbapenems.

Uses

Doripenem (doripenem monohydrate) is an ultra-broad spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems. It is particularly active against Pseudomonas aeruginosa

Application

Doripenem monohydrate can be used as the precursor for the preparation of doripenem which may be used as an analytical reference standard for the determination of doripenem in:
Bovine muscle by liquid chromatography combined with tandem mass spectrometry (LC-MS/MS).
Bulk drug and formulations by high performance thin layer chromatography (HPTLC).
Medicinal products by capillary electrophoresis coupled to ultraviolet (UV) detector as well as micellar electrokinetic chromatography (MEKC) with UV detection.

Definition

ChEBI: Doripenem hydrate is a member of carbapenems.

Biochem/physiol Actions

Doripenem is an ultra-broad spectrum carbopenem antibiotic. Doripenem is active against both gram-positive and gram-negative bacteria.

Mode of action

Doripenem hydrate is a β-lactam antibiotic of the carbapenem class. It is effective against extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae, a microbe resistant to many first line beta-lactam antibiotics and certain cephalosporins. Doripenem hydrate is sparingly soluble in aqueous solution.
β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases; however, carbapenems, including doripenem, are highly resistant to β-lactamases.

References

[1]. yutaka nishino, makoto kobayashi, taneyoshi shinno, et al. practical large-scale synthesis of doripenem: a novel 1a-methylcarbapenem antibiotic. organic process research & development, 2003, 7:846-850.
[2]. masakatsu tsuji, yoshikazu ishii, akira ohno, et al. in vitro and in vivo antibacterial activities of s-4661, a new carbapenem. antimicrobial agents and chemotherapy, 1998, 42(1): 94-99.
[3]. yunhua chen, elizabeth garber, qiuqu zhao, et al. in vitro activity of doripenem (s-4661) against multidrug-resistant gram-negative bacilli isolated from patients with cystic fibrosis. antimicrobial agents and chemotherapy, 2005, 49(6):2510-2511.

Doripenem hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Doripenem hydrate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Doripenem hydrate 364622-82-2
Price: US $1.00-1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-05-07

Zhuozhou Wenxi import and Export Co., Ltd

Product: Doripenem hydrate 364622-82-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Doripenem hydrate 364622-82-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

364622-82-2, Doripenem hydrateRelated Search:

Doripenem (4R,5S,6S)-3-[[(3S,5S)-5-[[(Aminosulfonyl)amino]methyl]-1-[[(4-nitrophenyl)methoxy]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester Meropenem ACS-PNZ-PYRROLIDYL-(BOC)-NSO2NH2 BIAPENEM SIDE CHAIN 3-[(2S,4S)-4-Mercaptopyrrolidine-2-carboxamido]benzoic acid hydrochloride 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid Ertapenem sodium Side chain for meropenem Biapenem Rosuvastatin calcium Cisplatin AG 490 GOSSYPOL Temozolomide Fulvestrant Thienamycin Doripenem hydrate

(+)-(4r,5s,6s)-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-3-[[(3s,5s)-5-[(sulfamoylamino)-methyl]-3-pyrrolidinyl]thio]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate

doripenem hydrate

DoripeneM Crude

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, hydrate

(4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Doripenem monohydrate, >=99%

(4R,5S,6S)-6-((R)-1-Hydroxyethyl)-4-methyl-7-oxo-3-(((3S,5S)-5-((sulfamoylamino)methyl)pyrroli

S 4661 monohydrate

(4R,5S,6S)-6-((R)-1-Hydroxyethyl)-4-methyl-7-oxo-3-(((3S,5S)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate

Doripenem hydrate USP/EP/BP

DORIPENEM MONOHYDRATE STERILE

Doripenem Hydrate (S 4661)

Doripenem monohydrateQ: What is Doripenem monohydrate Q: What is the CAS Number of Doripenem monohydrate Q: What is the storage condition of Doripenem monohydrate

2H5]-Doripenem

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, hydrate (1:1), (4R,5S,6S)-

(4R,5S,6S)-3-[[(3S,5S)-5-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate (1:1)

Doripenem Hydrate/Doribax/S-4661/Finibax

Finibax

364622-82-2

34622-82-2

C15H24N4O6S2H2O

C15H26N4O7S2

Doribax, Doripenem monohydrate, S-4661, Finibax

Inhibitors