Overview Reference quality standards The current status of Chinese imipenem drugs
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BIAPENEM SIDE CHAIN

Overview Reference quality standards The current status of Chinese imipenem drugs
Product Name
BIAPENEM SIDE CHAIN
CAS No.
153851-71-9
Chemical Name
BIAPENEM SIDE CHAIN
Synonyms
Biapenem Side;BIAPENEM SIDE CHAIN;Biopenem side chain;Biapenem impurity 62;Side Chain of BiapeneM;Side chain for Biapenem ;Biapenem Related Compound 6;Biapenem Impurity 2 Chloride;BIAPENEM SIDE CHAIN USP/EP/BP;TIANFU CHEM-- BIAPENEM SIDE CHAIN
CBNumber
CB2349288
Molecular Formula
C5H8ClN3S
Formula Weight
177.66
MOL File
153851-71-9.mol
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BIAPENEM SIDE CHAIN Property

Melting point:
127-128 °C (decomp)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Sparingly, Heated), Methanol (Slightly)
form 
Solid
color 
White to Off-White Waxy
CAS DataBase Reference
153851-71-9(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D452923
Product name
6,7-Dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]-triazoliumChloride
Packaging
500mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
L840
Product name
6,7-Dihydro-6-mercapto-5h-pyrazolo[1,2-a][1,2,4]triazol-4-iumchloride
Packaging
10g
Price
$275
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0068770
Product name
SIDE CHAIN FOR BIAPENEM
Purity
95.00%
Packaging
1G
Price
$788.29
Updated
2021/12/16
Ambeed
Product number
A434196
Product name
6,7-dihydro-6-mercapto-5H-Pyrazolo[1,2-a][1,2,4]triazol-4-iumchloride
Purity
97%
Packaging
250mg
Price
$12
Updated
2021/12/16
Ambeed
Product number
A434196
Product name
6,7-dihydro-6-mercapto-5H-Pyrazolo[1,2-a][1,2,4]triazol-4-iumchloride
Purity
97%
Packaging
1g
Price
$35
Updated
2021/12/16
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BIAPENEM SIDE CHAIN Chemical Properties,Usage,Production

Overview

Biapenem side chain is a pharmaceutical raw material that can be used to produce Biapenem antibiotics. Biapenem (LJC 10627) is a carbapenem antibiotic for injection developed by Japanese Lederle Company and American Cyanamid Company in 1989. It is now completed in Phase III clinical studies in Japan and waits for approval. The most significant feature of this product is that the S in 2-position has bicyclic triazole 1β-methyl carbapenem. The study of structure-activity relationship shows that the presence of the side chain quaternary ammonium cation center is the key to affect the permeability of the outer membrane, so that its ability to inhibit the activity of pseudomonas aeruginosa and anaerobic bacteria is 2~4 times that of imipenem, its ability to inhibit the activity of drug-resistant pseudomonas aeruginosa is 4 to 8 times that of Meropenem, and its effect on acinetobacter and anaerobic bacteria is more effective than ceftazidime.

Reference quality standards

Appearance: white to yellowish crystalline powder
Determination of content: 98%
Specific rotation:-26.0 ° to-36.0 °
pH: 4.5 to 6.0
Single Impurity: <1.0%
Total Impurities: <3.0%
Tetrahydrofuran and acetone: tetrahydrofuran less than 0.072%, acetone less than 0.5%
Loss on drying: no more than 1.0%
Residue on ignition: no more than 0.2%
Heavy metals: no more than 20ppm

The current status of Chinese imipenem drugs

Penem drugs are the antibiotics that have the most wide antibacterial spectrum and stronger antibacterial activity, and therefore play an important role for the last line of defense of serious anti-clinical infection. In recent years, the serious problem of drug-resistant bacteria make the use of these drugs in the global and domestic have a rapid growth, and the world has listed 6 drug types of imipenem-cilastatin, panipenem-betamipron, meropenem, biapenem (Biopenone Side Chain), ertapenem and doripenem. However, the penem drugs is clinically used as a second-line drug, the government's guiding principle for rational application of antibiotics and the expensive price all greatly limit the use expansion of these drugs. These factors determine that this class of drugs in the short term is still a "nobility" variety with high added value and small scale. In 2008, the terminal sales scale of penem drugs in Chinese market was 19.9 billion yuan (equivalent to US $ 278 million), accounting for 9% of the global total sales (nearly $ 3 billion). The sales mumble was about 12.43 million and the consumption of raw materials was 5~6 ton/year, in which domestic raw materials were 1.9 tons (1.8 tons of meropenem, 0.14 tons of imipenem) and accounted for 36%.
In the raw material export market of 2008, the raw materials export volume of the three major penem products of China (meropenem, imipenem and intermediate 4-AA) were respectively 6 tons, 1.3 tons and 40 tons, accounting for more than 60% of the global generic drug market demand for raw materials.
Since 2009, with the continuous growth of international market demand, China's technical costs of raw materials and intermediates gradually have advantages, especially meropenem shares a larger share in the international market and has a certain discourse power of price. In 2009, the annual export volume of meropenem and 4-AA is expected to reach 8 tons and 50 tons, with a growth rate of about 30%. Penem drugs will continue to grow rapidly and steadily according to their "rhythm".

Chemical Properties

White to off-white waxy solid

BIAPENEM SIDE CHAIN Preparation Products And Raw materials

Raw materials

Preparation Products

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BIAPENEM SIDE CHAIN Suppliers

Hunan Kaimir Biotechnology Co., Ltd.
Tel
0731-+86-0731-89714511 +86-18602659358
Fax
0731-89714511
Email
sales@chemapi.com.cn
Country
China
ProdList
34
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8012
Advantage
62
Jiangsu Yutian pharmaceutical Co.,Ltd.
Tel
18861350580 18861350582
Email
yutian02@jsytsw.com
Country
China
ProdList
80
Advantage
58
Cangzhou Dafeng Chemical Co., Ltd
Tel
18006162369
Email
dfhxchemical@163.com
Country
China
ProdList
18
Advantage
58
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-5032306 18917961636
Fax
+86-556-5032307
Email
wtx@bayeebio.com
Country
China
ProdList
261
Advantage
61
Hangzhou Read Chemical Co., Ltd
Tel
15306818081 15306818081
Fax
0571-87234255
Email
sales@hzread.com
Country
China
ProdList
61
Advantage
58
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Shanghai Buddy Bio-pharm Intermediates Ltd
Tel
021-50460499 13120992296
Fax
021-50460489
Email
xinxiaojuan513@163.com
Country
China
ProdList
24
Advantage
64
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9513
Advantage
66
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View Lastest Price from BIAPENEM SIDE CHAIN manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Biapenem Side Chain 153851-71-9
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-07
PNP Biotech Co. Ltd
Product
Biapenem Side Chain 153851-71-9
Price
US $0.00/kg
Min. Order
25kg
Purity
98%-99%
Supply Ability
Inquiry
Release date
2022-09-16
PNP Biotech Co. Ltd
Product
Side Chain For Biapenem 153851-71-9
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
Inquiry
Release date
2023-07-12

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