Overview Reference quality standards The current status of Chinese imipenem drugs
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BIAPENEM SIDE CHAIN

Overview Reference quality standards The current status of Chinese imipenem drugs
Product Name
BIAPENEM SIDE CHAIN
CAS No.
153851-71-9
Chemical Name
BIAPENEM SIDE CHAIN
Synonyms
Biapenem Side;BIAPENEM SIDE CHAIN;Biopenem side chain;Side Chain of BiapeneM;Side chain for Biapenem　;Biapenem Related Compound 6;Biapenem Impurity 2 Chloride;BIAPENEM SIDE CHAIN USP/EP/BP;TIANFU CHEM-- BIAPENEM SIDE CHAIN;2-Methyl-186-nitrobenzyl&chloride
CBNumber
CB2349288
Molecular Formula
C5H8ClN3S
Formula Weight
177.66
MOL File
153851-71-9.mol
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BIAPENEM SIDE CHAIN Property

Melting point:
127-128 °C (decomp)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Sparingly, Heated), Methanol (Slightly)
form 
Solid
color 
White to Off-White Waxy
CAS DataBase Reference
153851-71-9(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D452923
Product name
6,7-Dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]-triazoliumChloride
Packaging
500mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
L840
Product name
6,7-Dihydro-6-mercapto-5h-pyrazolo[1,2-a][1,2,4]triazol-4-iumchloride
Packaging
10g
Price
$275
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0068770
Product name
SIDE CHAIN FOR BIAPENEM
Purity
95.00%
Packaging
1G
Price
$788.29
Updated
2021/12/16
AvaChem
Product number
2215
Product name
6,7-Dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazolium chloride
Packaging
25g
Price
$275
Updated
2021/12/16
Abosyn
Product number
61-5046
Product name
6-mercapto-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-iumchloride
Purity
95+%
Packaging
10g
Price
$300
Updated
2021/12/16
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BIAPENEM SIDE CHAIN Chemical Properties,Usage,Production

Overview

Biapenem side chain is a pharmaceutical raw material that can be used to produce Biapenem antibiotics. Biapenem (LJC 10627) is a carbapenem antibiotic for injection developed by Japanese Lederle Company and American Cyanamid Company in 1989. It is now completed in Phase III clinical studies in Japan and waits for approval. The most significant feature of this product is that the S in 2-position has bicyclic triazole 1β-methyl carbapenem. The study of structure-activity relationship shows that the presence of the side chain quaternary ammonium cation center is the key to affect the permeability of the outer membrane, so that its ability to inhibit the activity of pseudomonas aeruginosa and anaerobic bacteria is 2~4 times that of imipenem, its ability to inhibit the activity of drug-resistant pseudomonas aeruginosa is 4 to 8 times that of Meropenem, and its effect on acinetobacter and anaerobic bacteria is more effective than ceftazidime.

Reference quality standards

Appearance: white to yellowish crystalline powder
Determination of content: 98%
Specific rotation:-26.0 ° to-36.0 °
pH: 4.5 to 6.0
Single Impurity: <1.0%
Total Impurities: <3.0%
Tetrahydrofuran and acetone: tetrahydrofuran less than 0.072%, acetone less than 0.5%
Loss on drying: no more than 1.0%
Residue on ignition: no more than 0.2%
Heavy metals: no more than 20ppm

The current status of Chinese imipenem drugs

Penem drugs are the antibiotics that have the most wide antibacterial spectrum and stronger antibacterial activity, and therefore play an important role for the last line of defense of serious anti-clinical infection. In recent years, the serious problem of drug-resistant bacteria make the use of these drugs in the global and domestic have a rapid growth, and the world has listed 6 drug types of imipenem-cilastatin, panipenem-betamipron, meropenem, biapenem (Biopenone Side Chain), ertapenem and doripenem. However, the penem drugs is clinically used as a second-line drug, the government's guiding principle for rational application of antibiotics and the expensive price all greatly limit the use expansion of these drugs. These factors determine that this class of drugs in the short term is still a "nobility" variety with high added value and small scale. In 2008, the terminal sales scale of penem drugs in Chinese market was 19.9 billion yuan (equivalent to US $ 278 million), accounting for 9% of the global total sales (nearly $ 3 billion). The sales mumble was about 12.43 million and the consumption of raw materials was 5~6 ton/year, in which domestic raw materials were 1.9 tons (1.8 tons of meropenem, 0.14 tons of imipenem) and accounted for 36%.
In the raw material export market of 2008, the raw materials export volume of the three major penem products of China (meropenem, imipenem and intermediate 4-AA) were respectively 6 tons, 1.3 tons and 40 tons, accounting for more than 60% of the global generic drug market demand for raw materials.
Since 2009, with the continuous growth of international market demand, China's technical costs of raw materials and intermediates gradually have advantages, especially meropenem shares a larger share in the international market and has a certain discourse power of price. In 2009, the annual export volume of meropenem and 4-AA is expected to reach 8 tons and 50 tons, with a growth rate of about 30%. Penem drugs will continue to grow rapidly and steadily according to their "rhythm".

Chemical Properties

White to off-white waxy solid

BIAPENEM SIDE CHAIN Preparation Products And Raw materials

Raw materials

Preparation Products

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BIAPENEM SIDE CHAIN Suppliers

China 248 Germany 2 India 4 Ukraine 1 United Kingdom 4 United States 15 Global 274
Hunan Kaimir Biotechnology Co., Ltd.
Tel
0731-+86-0731-89714511 +86-18602659358
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0731-89714511
Email
sales@chemapi.com.cn
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China
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ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
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China
ProdList
8019
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62
Jiangsu Yutian pharmaceutical Co.,Ltd.
Tel
0518-86098000 18861350683
Email
lfan@jsytsw.com
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China
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80
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58
Cangzhou Dafeng Chemical Co., Ltd
Tel
18006162369
Email
dfhxchemical@163.com
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China
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18
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58
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-0556-5032306 18917961636
Fax
+86-556-5032307
Email
wtx@bayeebio.com
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China
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253
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61
Chembest Research Laboratories Limited
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021-20908456
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021-58180499
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sales@BioChemBest.com
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6009
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Shanghai Buddy Bio-pharm Intermediates Ltd
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021-50460499 13120992296
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021-50460489
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xinxiaojuan513@163.com
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China
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24
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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0573-85285100
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isenchem@163.com
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9492
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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zhangsn@titansci.com
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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info@chemlin.com.cn
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China
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18086
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64
XiaoGan ShenYuan ChemPharm co,ltd
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15527768850
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1791901229@qq.com
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Syntechem Co.,Ltd
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Fax
E-Mail Inquiry
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info@syntechem.com
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Wuhan Kemi-Works Chemical Co., Ltd
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027-85736489
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86-27-85736485
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info@kemiworks.net
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542
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Beijing HuaMeiHuLiBiological Chemical
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010-56205725
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010-65763397
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58
NCE Biomedical Co.,Ltd.
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
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Shanghai Jian Chao Chemical Technology Co., Ltd.
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18017383231 18017383231
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qq：2817624287
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lyh_antaeus@163.com
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Shanghai Record Pharmaceuticals Limited Company
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86-21-62506791
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86-21-63636419
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record@recordpharm.com
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38
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73
Shanghai Arbor Chemical Co., Ltd.
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021-021-60451683 15021268886
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Shanghai Witofly Chemical Co.,Ltd
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Wuhan DKY Technology Co.,Ltd.
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27-81302488 18007166089
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027-81302088
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Hubei XinyuanShun Chemical Co., Ltd.
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13971561712, 13995564702, 027-50664929
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hbeixys2001@163.com
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Bide Pharmatech Ltd.
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400-1647117 15221909166
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+86-21-61629029
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Chemwill Asia Co.,Ltd.
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86-21-51086038
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86-21-51861608
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ChemStrong Scientific Co.,Ltd
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0755-0755-66853366 13670046396
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0755-28363542
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sales@chem-strong.com
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Finetech Industry Limited
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027-87465837 19945049750
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027-8777-2287
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Wuhan Dahua Pharmaceutical Co., Ltd.
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027-59262863 13277907145 3091977954
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027-59420980
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SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
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021-69106960 13701823733
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13701823733@163.com
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Shanghai HuanChuan Industry Co.,Ltd.
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021-61478794
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50
Shenzhen Nexconn Pharmatechs Ltd.
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admin@nexconn.com
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Beijing Holiyang Chemical Co. Ltd.
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Shanghai YouPeng Chemical Co. Ltd.
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021-69005955 13701776567
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Sichuan Hainuowei Technology Co. Ltd.
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13708085536
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Shanghai TongYuan Chemical Co., Ltd.
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Shanghai Kaisai Chemical Co., Ltd
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Credit Asia Chemical Co., Ltd.
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+86 (21) 6129-4103
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Shanghai LanRun Chemical Co., Ltd.
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021-69515658 ; 69515628 13701998368
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Shanghai Rolead Chemical Technology Co., Ltd.
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Shanghai Kangtuo Chemical Co., Ltd.
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Hubei Jusheng Technology Co.,Ltd
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027-59599241 18871490274
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Intelligence Pharm Science(Shanghai) Co., Ltd.
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021-57898186
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021-37699262
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Kono Chem Co.,Ltd
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15829389671
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029-86107037
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Shanghai Synchem Pharma Co., ltd
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21-619849051-1 18521059765
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Jinan Putubio Tech Co., Ltd.
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+86 (531) 8099-2215
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Shanghai QianYan Bio-technology Co., Ltd
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02781293128
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Shanghai XiZhi Chemical Co., Ltd.
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021-69005855 13701817869
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021-69005955
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Shanghai Pengsuo Biochemical Technology Co., Ltd.
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021-59118555 13701823997
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Shandong Xiya Chemical Co., Ltd.
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4009903999 13395398332
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0539-6365991
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Nanjing Ally Chemical S&T Co., Ltd.
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025-025-58367986 18913956109
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QQ:3209878052
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Zhengzhou Acme Chemical Co., Ltd.
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0371-0371-55629727 13323845623
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037155629727
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Shenzhen Simeiquan Biotechnology Co. Ltd
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18126413629 0755-23311925 2355327053
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0755-23311925
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abel@ycgmp.com
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View Lastest Price from BIAPENEM SIDE CHAIN manufacturers

PNP Biotech Co. Ltd
Product
Biapenem Side Chain 153851-71-9
Price
US $0.00/kg
Min. Order
25kg
Purity
98%-99%
Supply Ability
Inquiry
Release date
2022-09-16
PNP Biotech Co. Ltd
Product
Side Chain For Biapenem 153851-71-9
Price
US $0.00/kg
Min. Order
25kg
Purity
98%
Supply Ability
Inquiry
Release date
2023-07-12
Shaanxi Dideu Medichem Co. Ltd
Product
Biapenem Side Chain 153851-71-9
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-07

153851-71-9, BIAPENEM SIDE CHAINRelated Search:

Potassium chloride Sodium chloride Mercaptoacetic acid Biapenem (Z)-2-Amino-alpha-[1-(tert-butoxycarbonyl)]-1-methylethoxyimino-4-thiazolacetic acid Zolpidem tartrate Ammonium chloride Thionyl chloride Side chain for meropenem 3-Mercaptopropionic acid Polyvinyl chloride Pyraclostrobin Calcium thioglycolate Choline chloride Calcium chloride POTASSIUM THIOGLYCOLATE 2-Ethylhexyl mercaptoacetate Biapenem Impurity 33

  • 6-sulfanyl-5H,6H,7H-2,4000000$l^{5},8000000-pyrazolo[1,2-a][1$l^{5},2,4]triazol-4-yliuM chloride
  • 6,7-dihydro-6-mercapto-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride
  • 6,7-DIHYDRO-6-MERCAPTO-5H-PYRAZOLO(1,2-A) (1,2,4)-TRIAZOLIUM CHLORIDE
  • 5H-PYRAZOLO[1,2-A][1,2,4]TRIAZOL-4-IUM, 6,7-DIHYDRO-6-MERCAPTO-, CHLORIDE
  • Biapenem Side
  • 6-MERCAPTO-6,7-DIHYDRO-5H-PYRAZOLO[1,2-A][1,2,4]TRIAZOL-4-YLIUM
  • Side chain for biapenem, 6,7-dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazolium chloride, 6,7-dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium,
  • Side chain for Biapenem　
  • SIDE CHAIN FOR BIAPENEM 97+%（HPLC）
  • 5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium,6,7-dihydr
  • BiapeneM side chain-6,7-dihydro-6-Mercapto-5H-pyrazolo[1,2-a] [1,2,4] triazole chloride 6,7-dihydro-6-thiol-5h-pyrazolo [1,2-a] [1,2,4] triazole chloride
  • 6-Mercapto-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ylium chloride (Side chain for biapenem)
  • 6,7-dihydro-6-mercapto-5H-pyrazolo[1,2-a][1,2,4]triazolium chloride (the sidechain of biapenem)
  • BIAPENEM SIDE CHAIN
  • 6,7-DIHYDRO-6-MERCAPTO-5H-PYRAZOLO[1,2-ALPHA][1,2,4]TRIAZOLIUMCHLORIDE
  • 5H-Pyrazolo[1,2-a][1,2,4] triazol-4-ium, 6,7-dihydro-6-mercapto-, chlo
  • 6-Mercapto-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-iuM chloride
  • 6-sulfanyl-1H,5H,6H,7H-pyrazolo[1,2-a][1,2,4]triazol-1-yliuM chloride
  • Side Chain of BiapeneM
  • Biapenem Related Compound 6
  • BIAPENEM SIDE CHAIN USP/EP/BP
  • Biopenem side chain
  • 6,7-dihydro-6-mercapto-5h-pyrazolo[1,2-a][1,2,4]triazol-4-iu...
  • TIANFU CHEM-- BIAPENEM SIDE CHAIN
  • 2-Methyl-186-nitrobenzyl&chloride
  • 6,7- dihydro -6- mercapto -5H- pyrazole [1,2-a][1,2,4] triazolenenium chloride
  • 5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium, 6,7-dihydro-6-mercapto-, chloride (1:1)
  • 6,7-dihydro-6-mercapto-5H-Pyrazolo[1,2-a][1,2,4]triazol-4-ium chloride (1:1)
  • Biapenem Impurity 2 Chloride
  • 153851-71-9
  • 135851-71-9
  • C5H8ClN3S
  • API intermediates
  • (the sidechain of biapenem)
  • Chemical intermediate for Biapenem
  • Pharmaceutical intermediate
  • Other Products