MAC-545496

Product Name: MAC-545496
CAS No.: 838810-96-1
Chemical Name: MAC-545496
Synonyms: MAC-545496;MAC-545496, 10 mM in DMSO;N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide;N-[[(5-Chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)benzamide;Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)-;Bacterial,S. aureus,Antivirulence,Inhibitor,MAC545496,mprF,nanomolar,GraR,MAC-545496,MRSA,survival,inhibit,biofilm,MAC 545496,virulence,β-lactam
CBNumber: CB06124311
Molecular Formula: C18H18ClN5O3S
Formula Weight: 419.89
MOL File: 838810-96-1.mol

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MAC-545496 Property

Density: 1.458±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO (25 mg/ml)
form: solid
pka: 7.09±0.70(Predicted)
color: Yellow/orange
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0109477
Product name: MAC-545496
Purity: 99.72%
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0109477
Product name: MAC-545496
Purity: 99.72%
Packaging: 10mg
Price: $160
Updated: 2021/12/16

Adipogen Life Sciences

Product number: AG-CR1-0163-M005
Product name: MAC-545496
Purity: ≥98%(HPLC)
Packaging: 5mg
Price: $210
Updated: 2021/12/16

ChemScene

Product number: CS-0109477
Product name: MAC-545496
Purity: 99.72%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

Ambeed

Product number: A1263957
Product name: N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide
Purity: 98%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

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MAC-545496 Chemical Properties,Usage,Production

Description

MAC-545496 (838810-96-1) is an inhibitor of glycopeptide-resistance-associated protein R (GraR, also known as ApsR).? GraR and its regulatory system are important for virulence of S. aureus.? MAC-545496 is able to reverse ?-lactam resistance in S. aureus in a G. Mellonella larvae model.? 0.06 μg/mL MAC-545496? lowered the minimum inhibitory concentration (MIC) for oxacillin against S. aureus below the CLSI clinical breakpoint. It lowered the ?-lactam MIC from 512 to 8 μg/mL against S. aureus USA300.

References

El-Halfawy et al. (2020), Discovery of an antivirulence compound that reverses ?-lactam resistance in MRSA; Nat. Chem. Biol., 16 143

MAC-545496 Preparation Products And Raw materials

Raw materials

Preparation Products

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MAC-545496 Suppliers

China 45 United States 5 Global 50

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4573
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Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 1005
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27313
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
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Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2998
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
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Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
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ProdList: 1925
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Heze Development Zone chuangli Chemical Co., Ltd.

Tel: +86-530-529 6766，+86-15666160102 15666160102
Fax: 0530-529 6766
Email: info@chuangli-chem.com
Country: China
ProdList: 899
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

838810-96-1, MAC-545496Related Search:

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MAC-545496

Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)-

N-[[(5-Chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)benzamide

Bacterial,S. aureus,Antivirulence,Inhibitor,MAC545496,mprF,nanomolar,GraR,MAC-545496,MRSA,survival,inhibit,biofilm,MAC 545496,virulence,β-lactam

N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide

MAC-545496, 10 mM in DMSO

838810-96-1