MAC-545496
- Product Name
- MAC-545496
- CAS No.
- 838810-96-1
- Chemical Name
- MAC-545496
- Synonyms
- MAC-545496;MAC-545496, 10 mM in DMSO;N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide;N-[[(5-Chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)benzamide;Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)-;Bacterial,S. aureus,Antivirulence,Inhibitor,MAC545496,mprF,nanomolar,GraR,MAC-545496,MRSA,survival,inhibit,biofilm,MAC 545496,virulence,β-lactam
- CBNumber
- CB06124311
- Molecular Formula
- C18H18ClN5O3S
- Formula Weight
- 419.89
- MOL File
- 838810-96-1.mol
MAC-545496 Property
- Density
- 1.458±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (25 mg/ml)
- form
- solid
- pka
- 7.09±0.70(Predicted)
- color
- Yellow/orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- CS-0109477
- Product name
- MAC-545496
- Purity
- 99.72%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0109477
- Product name
- MAC-545496
- Purity
- 99.72%
- Packaging
- 50mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- CS-0109477
- Product name
- MAC-545496
- Purity
- 99.72%
- Packaging
- 10mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- AG-CR1-0163-M005
- Product name
- MAC-545496
- Purity
- ≥98%(HPLC)
- Packaging
- 5mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- A1263957
- Product name
- N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide
- Purity
- 98%
- Packaging
- 50mg
- Price
- $360
- Updated
- 2021/12/16
MAC-545496 Chemical Properties,Usage,Production
Description
MAC-545496 (838810-96-1) is an inhibitor of glycopeptide-resistance-associated protein R (GraR, also known as ApsR).? GraR and its regulatory system are important for virulence of S. aureus.? MAC-545496 is able to reverse ?-lactam resistance in S. aureus in a G. Mellonella larvae model.? 0.06 μg/mL MAC-545496? lowered the minimum inhibitory concentration (MIC) for oxacillin against S. aureus below the CLSI clinical breakpoint. It lowered the ?-lactam MIC from 512 to 8 μg/mL against S. aureus USA300.
References
El-Halfawy et al. (2020), Discovery of an antivirulence compound that reverses ?-lactam resistance in MRSA; Nat. Chem. Biol., 16 143
MAC-545496 Preparation Products And Raw materials
Raw materials
Preparation Products
MAC-545496 Suppliers
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- +1-781-999-5354 +1-00000000000
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- United States
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- +1-+1(833)-552-7181
- sales@aladdinsci.com
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- support@targetmol.com
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