ChemicalBook > CAS DataBase List > 2-AMINO-6-CHLORO-PHENOL

2-AMINO-6-CHLORO-PHENOL

Product Name: 2-AMINO-6-CHLORO-PHENOL
CAS No.: 38191-33-2
Chemical Name: 2-AMINO-6-CHLORO-PHENOL
Synonyms: 2-AMino-6-chlorphenol;2-AMINO-6-CHLORO-PHENOL;2-chloro-6-aMinophenole;3-Chloro-2-hydroxyaniline;phenol, 2-amino-6-chloro-
CBNumber: CB0655640
Molecular Formula: C6H6ClNO
Formula Weight: 143.57
MOL File: 38191-33-2.mol

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2-AMINO-6-CHLORO-PHENOL Property

Melting point:: 80-81℃
Boiling point:: 247℃
Density: 1.406
Flash point:: 103℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: solid
pka: 8.28±0.10(Predicted)
color: Grey
InChI: InChI=1S/C6H6ClNO/c7-4-2-1-3-5(8)6(4)9/h1-3,9H,8H2
InChIKey: QUIIUKFPLUUSGQ-UHFFFAOYSA-N
SMILES: C1(O)=C(Cl)C=CC=C1N

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2922290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: TMT00393
Product name: 2-Amino-6-chlorophenol
Packaging: 1 g
Price: $550
Updated: 2025/07/31

TRC

Product number: A576675
Product name: 2-Amino-6-chlorophenol
Packaging: 500mg
Price: $40
Updated: 2021/12/16

TRC

Product number: A576675
Product name: 2-Amino-6-chlorophenol
Packaging: 5g
Price: $300
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4656-5-92
Product name: 2-Amino-6-chlorophenol
Packaging: 5G
Price: $240
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA120252
Product name: 2-Amino-6-chlorophenol
Packaging: 5G
Price: $300
Updated: 2021/12/16

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2-AMINO-6-CHLORO-PHENOL Chemical Properties,Usage,Production

Uses

2-Amino-6-Chlorophenol is used to synthesize HT2C receptor agonists with high selectivity in functional and binding assays.

Synthesis

603-86-1

38191-33-2

General procedure for the synthesis of 2-amino-6-chlorophenol from 2-chloro-6-nitrophenol: 2-chloro-6-nitrophenol (1.05 g, 6.03 mmol) was mixed with tin powder (2.32 g, 19.5 mmol) in glacial acetic acid, and the reaction was stirred for 18 hours at 80 °C. After completion of the reaction, the reaction mixture was diluted with deionized water (120 mL) and filtered to remove insoluble material. The filtrate was extracted with ethyl acetate (1 x 100 mL, followed by 2 x 50 mL). The organic phases were combined, washed with saturated saline (3 × 50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by rapid column chromatography on silica gel (eluent ratio 2:1 hexane:ethyl acetate) afforded 2-amino-6-chlorophenol as a brown to white crystalline solid (476 mg, 55% yield).1H-NMR (500 MHz, CDCl3) δ 6.73 (dd, J = 1.7, 8.1 Hz, 1H), 6.69 (t, J = 7.8 Hz, 1H ), 6.62 (dd, J = 1.7, 7.7 Hz, 1H), 5.46 (br s, 1H), 3.84 (br s, 2H); 13C-NMR (125 MHz, CDCl3) δ 139.32, 135.73, 121.28, 119.87, 118.31, 114.42; ESI-MS m/z 144 [M +H]+, calculated value of 144 for the molecular formula C6H7ClNO.

References

[1] Liebigs Annalen der Chemie, 1994, # 3, p. 269 - 276
[2] Journal of the Iranian Chemical Society, 2018, vol. 15, # 2, p. 281 - 291
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 23, p. 7974 - 7985
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 15, p. 3521 - 3525
[5] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3441 - 3449

2-AMINO-6-CHLORO-PHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-AMINO-6-CHLORO-PHENOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Amino-6-chlorophenol 38191-33-2
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-14

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-AMINO-6-CHLORO-PHENOL 38191-33-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-08

Shaanxi Dideu Medichem Co. Ltd

Product: 2-AMINO-6-CHLORO-PHENOL 38191-33-2
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-13

38191-33-2, 2-AMINO-6-CHLORO-PHENOLRelated Search:

2-CHLORO-4,6-DINITROPHENOL 6-CHLORO-2-AMINOPHENOL-4-SULFONIC ACID 2-Amino-6-chloro-4-nitrophenol 6-Amino-2,4-dichloro-3-methylphenol hydrochloride 2,4-Dichloro-3-methyl-6-nitrophenol 2-CHLORO-6-NITROPHENOL 4-(2-CHLORO-6-NITROPHENOXY)BENZENE-1-SULFONYL CHLORIDE 2-CHLORO-6-NITROANISOLE 2,4-Dichloro-6-nitrophenol 2-[2,4-Bis(tert-pentyl)phenoxy]-N-(3,5-dichloro-2-hydroxy-p-tolyl)butyramide 2,4-Dichloro-3-ethyl-6-nitrophenol 2-AMINO-4,6-DICHLOROPHENOL N-(3,5-DICHLORO-2-HYDROXY-4-METHYLPHENYL)-2-(2,4-DI-TERT-PENTYLPHENOXY)-ACETAMIDE 3-CHLORO-O-ANISIDINE 97 GALLION 1,2-DICHLORO-3-(2,6-DICHLOROPHENOXY)-4-NITROBENZENE AURORA KA-4065 METHYL 3-(2-CHLORO-6-NITROPHENOXY)-2-THIOPHENECARBOXYLATE

phenol, 2-amino-6-chloro-

2-chloro-6-aMinophenole

3-Chloro-2-hydroxyaniline

2-AMino-6-chlorphenol

2-AMINO-6-CHLORO-PHENOL

38191-33-2