ChemicalBook > CAS DataBase List > Eflornithine hydrochloride

Eflornithine hydrochloride

Product Name
Eflornithine hydrochloride
CAS No.
68278-23-9
Chemical Name
Eflornithine hydrochloride
Synonyms
DFMO;DFMO HCL;RMI-71782;EflornitineHCl;EFLORNITHINE HCL;DFMO HYDROCHLORIDE;RMI-71782 HYDROCHLORIDE;Eflornitinehydrochloride;EFLORNITHINE HYDROCHLORIDE;Yifluorouracil hydrochloride
CBNumber
CB0663997
Molecular Formula
C6H13ClF2N2O2
Formula Weight
218.63
MOL File
68278-23-9.mol
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Eflornithine hydrochloride Property

Melting point:
181-184°C
storage temp. 
Store at -20°C
solubility 
H2O: >10 mg/mL, soluble
form 
solid
color 
white
Water Solubility 
Soluble to 75 mM in water
CAS DataBase Reference
68278-23-9(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D445843
Product name
DL-α-DifluoromethylornithineHydrochloride
Packaging
10mg
Price
$70
Updated
2021/12/16
TRC
Product number
D445843
Product name
DL-α-DifluoromethylornithineHydrochloride
Packaging
25mg
Price
$160
Updated
2021/12/16
AK Scientific
Product number
H211
Product name
EflornithineHCl
Packaging
25mg
Price
$98
Updated
2021/12/16
AK Scientific
Product number
H211
Product name
EflornithineHCl
Packaging
100mg
Price
$298
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002527
Product name
EFLORNITHINE HYDROCHLORIDE
Purity
95.00%
Packaging
5G
Price
$1784.48
Updated
2021/12/16
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Eflornithine hydrochloride Chemical Properties,Usage,Production

Uses

Antineoplastic; antiprotozoal.

Uses

DL-alpha-Difluoromethylornithine Hydrochloride is an irreversible inhibitor of ornithine decarboxylase.

Indications

Vaniqa (eflornithine hydrochloride 13.9%) cream is a unique topical cream that slows anagen hair growth by irreversibly blocking the enzyme ornithine decarboxylase. This enzyme produces polyamines in the hair matrix that are partially responsible for the growth of the anagen hair. The cream was tested only on the upper lip and chin region. The onset of action is usually within 8 weeks of starting the b.i.d. treatment, and the hair growth will return to baseline within 8 weeks of discontinuing the drug. Patients need to be reminded that this product does not remove hair but slows its growth in between whatever they use for hair removal.

brand name

Ornidyl (Sanofi Aventis); Vaniqa (Skinmedica).

in vivo

Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4].

IC 50

Trypanosoma

storage

Desiccate at RT

Eflornithine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Eflornithine hydrochloride Suppliers

China 116 Europe 2 Germany 1 India 8 Japan 1 Switzerland 2 United Kingdom 7 United States 27 Global 164
Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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Musechem
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View Lastest Price from Eflornithine hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Eflornithine hydrochloride 68278-23-9
Price
US $1.00-4.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1KG 100K
Release date
2025-05-19
Baoji Guokang Healthchem Co., Ltd.
Product
Eflornithine hydrochloride 68278-23-9
Price
US $2420.00/GK
Min. Order
100g
Purity
99%
Supply Ability
1000KG
Release date
2021-06-07
Shanghai Biolang Biotechnology Co., Ltd.
Product
Eflornithine hydrochloride 68278-23-9
Price
US $9.90-8.80/g
Min. Order
10g
Purity
99.99%HPLC.USP42
Supply Ability
1000kgs
Release date
2022-02-09

68278-23-9, Eflornithine hydrochlorideRelated Search:

L(+)-Ornithine hydrochloride L-Ornithine Topotecan hydrochloride Fluoxetine hydrochloride 1-AdaMantanethylaMine 2-(Difluoromethyl)-DL-ornithine DFMO 2-(Difluoromethyl)ornithine hydrate hydrochloride, DFMO hydrate hydrochloride,DFMO DL-Ornithine hydrochloride DFMO EFLORNITHINE DFMO ORNITHINE HC (S)-2-AMINO-2-METHYLBUTYRIC ACID BETA-FLUORO-DL-ALANINE 2,5-DIAMINO-2-METHYL-PENTANOIC ACID HCL 2-FLUORO-1,1-DIMETHYL-ETHYLAMINE HCL-SALT Eflornithine hydrochloride Levofloxacin HCL Capsule

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  • dl-ornithine,2-(difluoromethyl)-,monohydrochloride,hydrate
  • DFMO
  • DFMO HCL
  • DFMO HYDROCHLORIDE
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  • EFLORNITHINE HYDROCHLORIDE
  • DL-ALPHA-DIFLUOROMETHYLORNITHINE HYDROCHLORIDE
  • 2-(Difluoromethyl)-DL-ornithine monohydrochloride
  • DFMO (Ornithine Decarboxylase inhibitor DFMO)
  • 2-(DIFLUOROMETHYL)-ORNITHINE HYDROCHLORIDE
  • DL-alpha-Difluoromethylonithine
  • EflornitineHCl
  • Eflornitinehydrochloride
  • 2-(Difluoromethyl)-DL-Ornithine hydrochloride
  • Eflornithine hydrochloride API
  • 2,5-Diamino-2-(difluoromethyl)pentanoic acid hydrochloride hydrate
  • Eflornithine hydrochloride(DFMO)
  • Eflornithine hydrochloride USP/EP/BP
  • DL-α-Difluoromethylornithine Hydrochloride
  • Yifluorouracil hydrochloride
  • 68278-23-9
  • C6H12F2N2O2HCl
  • Amino Acids and Derivatives
  • facial hair remover