ChemicalBook > CAS DataBase List > TERT-BUTYLCARBAMIDINE HYDROCHLORIDE

TERT-BUTYLCARBAMIDINE HYDROCHLORIDE

Product Name: TERT-BUTYLCARBAMIDINE HYDROCHLORIDE
CAS No.: 18202-73-8
Chemical Name: TERT-BUTYLCARBAMIDINE HYDROCHLORIDE
Synonyms: tert-ButylcarbamidineHCl;pivalamidine hydrochloride;PivalamidineHydrochloride>2,2-DIMETHYLPROPIONAMIDINE HCL;2,2-Dimethylpropanimidamide HCl;T-BUTYLCARBAMIDINE HYDROCHLORIDE;trimethylacetamidine hydrochloride;TERT-BUTYLCARBAMIDINE HYDROCHLORIDE;2-Methylisobutanamidine hydrochloride;2,2-Dimethylpropanamidine hydrochloride
CBNumber: CB0666352
Molecular Formula: C5H13ClN2
Formula Weight: 136.62
MOL File: 18202-73-8.mol

Less

TERT-BUTYLCARBAMIDINE HYDROCHLORIDE Property

Melting point:: 190 °C
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: powder to crystal
color: White to Almost white
Sensitive: Hygroscopic
BRN: 3618865
InChIKey: ARDGQYVTLGUJII-UHFFFAOYSA-N
CAS DataBase Reference: 18202-73-8(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
HazardClass: IRRITANT
HS Code: 2921199990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S168351
Product name: 2,2-DIMETHYL-PROPIONAMIDINE, HYDROCHLORIDE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $30.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: S168351
Product name: 2,2-DIMETHYL-PROPIONAMIDINE, HYDROCHLORIDE
Purity: AldrichCPR
Packaging: 25MG
Price: $29.8
Updated: 2024/03/01

TCI Chemical

Product number: P1761
Product name: Pivalamidine Hydrochloride
Purity: >98.0%(N)(T)
Packaging: 5g
Price: $77
Updated: 2025/07/31

TCI Chemical

Product number: P1761
Product name: Pivalamidine Hydrochloride
Purity: >98.0%(N)(T)
Packaging: 25g
Price: $233
Updated: 2025/07/31

TRC

Product number: P550695
Product name: PivalimidamideHydrochloride
Packaging: 5g
Price: $135
Updated: 2021/12/16

Less

TERT-BUTYLCARBAMIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Pivalimidamide Hydrochloride is used as a reagent in the preparation of 2-alkyl-4-aryltetrahydropyridopyrimidines and 2-alkyl-4-aryl-tetrahydropyrimidoazepines as selective 5-HT2A antagonists.

Synthesis

630-18-2

75-36-5

18202-73-8

Step (1) Preparation of tert-butylamidine hydrochloride: To a magnetically stirred mixed solution of 2,2-dimethyl-1-propanenitrile (25.0 g, 0.30 mol) and anhydrous methanol (26.8 mL, 0.79 mol) was added dropwise acetyl chloride (25 mL, 0.36 mol) and ether (30 mL) at 0 °C. After the dropwise addition, stirring was continued at 0 °C for 15 min. Subsequently, the reaction mixture was stirred at room temperature for 3 days. After completion of the reaction, white crystals were obtained by filtration, washed with ether and dried under vacuum. The dried crystals were mixed with an ethanol solution of 10% ammonia (150 mL, 0.90 mol) and stirred at room temperature for 3 days. The reaction mixture was filtered and the filtrate was concentrated to give a white solid. Recrystallization by ethanol gave a white crystalline product (18.9 g, 46% yield) with a melting point of 205°C (literature value 188°-190°C). NMR hydrogen spectrum (DMSO-d6): δ 1.22 (s, 9H), 8.63 (br d, 3H).

References

[1] Patent: US4786640, 1988, A

TERT-BUTYLCARBAMIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Ethanol Acetone Pivaloyl chloride Diethyl ether Phosphorus pentoxide Ammonia

Preparation Products

Less

TERT-BUTYLCARBAMIDINE HYDROCHLORIDE Suppliers

Americas 1 Belgium 1 China 89 Germany 4 India 6 Japan 2 Switzerland 2 United Kingdom 12 United States 20 Global 137

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Aemon Chemical

Tel: 0086-755-86198205
Email: acinfo@aemonchem.com
Country: China
ProdList: 1931
Advantage: 57

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai Hong-chuang Pharma Tech Co., Ltd.

Tel: 18151128828
Fax: -
Email: hc-sales@foxmail.com
Country: China
ProdList: 2647
Advantage: 55

Shanghai Carlow Chemicals Co., Ltd.

Tel: 21-33526724 18930996265
Fax: 37023730
Email: info@carlowchem.com
Country: China
ProdList: 1922
Advantage: 58

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4526
Advantage: 56

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Changzhou Bestar Industry Co.,Ltd.

Tel: 0519-82309982
Fax: 0519-82309985
Country: China
ProdList: 129
Advantage: 55

Struchem Co., Ltd.

Tel: 0512-63009836 18994340901
Fax: 0512-63006936
Email: helen@struchem.com
Country: China
ProdList: 3981
Advantage: 60

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7992
Advantage: 55

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 6059
Advantage: 65

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Nanjing NingFan Pharm-Tech CO. LTD.

Tel: 17368696818
Country: China
ProdList: 1984
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Shanghai Zhibang Biological Medicine Co., LTD

Tel: 021-54285032 18116461626
Fax: 021-54285032
Email: 25493162@qq.com
Country: China
ProdList: 148
Advantage: 58

Henan Aosman Biotechnology Co., LTD

Tel: 0371-0371-61318675 17719817155
Fax: 0371-61318675
Email: sales@xlinebio.com
Country: China
ProdList: 2857
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

Shanghai zhigan biotechnology co., LTD

Tel
Email: zhiqianbio@126.com
Country: China
ProdList: 19778
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Shanghai Lanle Bird Industrial Co., Ltd.

Tel: 15021845385
Email: 765325601@qq.com
Country: China
ProdList: 3609
Advantage: 58

Xi'an Minze Pharmaceutical Technology Co., Ltd

Tel: 13981836672
Email: 2560370848@qq.com
Country: China
ProdList: 2807
Advantage: 58

Changzhou Ditong Chemical Co.,Ltd

Tel: +86-0519-88299272
Email: info@edengenechem.com
Country: China
ProdList: 2176
Advantage: 58

Shandong chuangyingchemical Co., Ltd.

Tel: 18853181302
Email: sale@chuangyingchem.com
Country: CHINA
ProdList: 5906
Advantage: 58

Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd

Tel: 037188900765 18037465274
Fax: QQ3430974218
Email: enyawanglei@sina.cn
Country: China
ProdList: 13965
Advantage: 58

Chengdu Feibo Pharm Technology Co., Ltd

Tel: +86 028-84641798 15982321820
Email: abby@arkpharm.com
Country: China
ProdList: 10000
Advantage: 58

Shaanxi borno biotechnology co., LTD

Tel: +86-13759708231
Email: asherw9@hotmail.com
Country: China
ProdList: 2373
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Shanghai Hanlin biology science and technology co., ltd

Tel: 183-0212-4410 18302124410
Email: Djt18302124410@163.com
Country: China
ProdList: 3000
Advantage: 58

Guangzhou Yunmen Biotechnology Co., Ltd

Tel: 0751-18902340975/189023400307 18902340307
Fax: 0751-2819901
Email: 3356812514@qq.com
Country: China
ProdList: 9249
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2815987 13927875076
Fax: 0751-2828607
Email: 3007432263@qq.com
Country: China
ProdList: 9963
Advantage: 58

YANCHENG JIANGZHONG CHEMICALS CO., LTD.

Tel: 0515-88981987 13918567443
Fax: 0515-88981987
Email: richard.li_jzchem@263.net
Country: China
ProdList: 174
Advantage: 58

Less

View Lastest Price from TERT-BUTYLCARBAMIDINE HYDROCHLORIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: TERT-BUTYLCARBAMIDINE HYDROCHLORIDE 18202-73-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: TERT-BUTYLCARBAMIDINE HYDROCHLORIDE 18202-73-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

18202-73-8, TERT-BUTYLCARBAMIDINE HYDROCHLORIDERelated Search:

Dimethylamine 2,2-DIMETHYLPROPIONAMIDINE 1-Methyl-cyclopropanecarboxamidine HCl 1-(2,4-dichlorophenyl)cyclopropanecarboxamidine PIVALIMIDOHYDRAZIDE HYDROCHLORIDE ADAMANTANE-1-CARBOXAMIDINE HYDROCHLORIDE 5,5-Diethyl-4-(2-chlorophenyl)iminobarbituric acid N,N-DIMETHYL-[1-T-BUTYL-3,3-BIS(DIMETHYLAMINO)-2-AZA-3-PROPENYLIDEN]-AMMONIUM PERCHLORATE PYRIDO[3,4-D]PYRIMIDIN-4(3H)-ONE, 6-CHLORO-2-(1,1-DIMETHYLETHYL)- 1-(4-chlorophenyl)cyclopropanecarboxamidine TERT-BUTYLCARBAMIDINE HYDROCHLORIDE

2,2-DIMETHYLPROPANIMIDAMIDE HYDROCHLORIDE

2,2-DIMETHYLPROPIONAMIDINE HCL

2,2-DIMETHYL-PROPIONAMIDINEHYDROCHLORIDE

TERT-BUTYLCARBAMIDINE HYDROCHLORIDE

T-BUTYLCARBAMIDINE HYDROCHLORIDE

tert-ButylcarbamidineHCl

trimethylacetamidine hydrochloride

pivalamidine hydrochloride

2,2,2-Trimethylacetamidine hydrochloride, 98%

Propanimidamide, 2,2-dimethyl-, hydrochloride (1:1)

2-Methylisobutanamidine hydrochloride

2,2-diMethylpropaneiMidaMide hydrochloride

2,2-Dimethylpropanamidine hydrochloride

2,2-Dimethylpropanimidamide hydrochloride, Pivalamidine hydrochloride

PivalamidineHydrochloride&gt

2,2-Dimethylpropanimidamide HCl

2,2-dimethyl-Propanimidamide hydrochloride (1:1)

18202-73-8

C5H12N2ClH

C5H13ClN2

pharmacetical

Aliphatics