2-HYDROXY-4-IODO-BENZALDEHYDE
- Product Name
- 2-HYDROXY-4-IODO-BENZALDEHYDE
- CAS No.
- 38170-02-4
- Chemical Name
- 2-HYDROXY-4-IODO-BENZALDEHYDE
- Synonyms
- 4-Iodo-2-hydroxybenzaldehyde;2-HYDROXY-4-IODO-BENZALDEHYDE;BENZALDEHYDE, 2-HYDROXY-4-IODO-
- CBNumber
- CB0668831
- Molecular Formula
- C7H5IO2
- Formula Weight
- 248.02
- MOL File
- Mol file
2-HYDROXY-4-IODO-BENZALDEHYDE Property
- Melting point:
- 87 °C
- Boiling point:
- 290.0±30.0 °C(Predicted)
- Density
- 2.039±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 7.32±0.10(Predicted)
- color
- Off-White
Safety
- HS Code
- 2913000090
N-Bromosuccinimide Price
- Product number
- HCH0354916
- Product name
- 2-HYDROXY-4-IODOBENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.6
- Updated
- 2021/12/16
- Product number
- 61-10218
- Product name
- 2-Hydroxy-4-iodobenzaldehyde
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $540
- Updated
- 2021/12/16
- Product number
- SC-62102
- Product name
- BENZALDEHYDE,2-HYDROXY-4-IODO-
- Purity
- 95
- Packaging
- 5g
- Price
- $1717
- Updated
- 2021/12/16
- Product number
- CD12076958
- Product name
- 2-Hydroxy-4-iodobenzaldehyde
- Purity
- 95%
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- CC00-2048
- Product name
- 2-Hydroxy-4-iodo-benzaldehyde
- Purity
- ＞98%
- Packaging
- 0.5g
- Price
- $175
- Updated
- 2021/12/16
2-HYDROXY-4-IODO-BENZALDEHYDE Chemical Properties,Usage,Production
Uses
2-hydroxy-4-iodobenzaldehyde is used in the preparation of anti-B7-H3 antibodies.
Synthesis
50-00-0
533-58-4
38170-02-4
Step 1: Preparation of 2-hydroxy-4-iodobenzaldehyde Magnesium chloride (MgCl2, 19.5 g, 204 mmol) was added batchwise to a frozen solution of commercially available 2-iodophenol (30 g, 136 mmol) in acetonitrile (ACN) while keeping the reaction temperature below 10 °C. Paraformaldehyde (28.6 g, 954 mmol) and triethylamine (TEA, 76 mL, 545 mmol) were subsequently added and the reaction was exothermic to 15 °C. The reaction mixture was heated to 72 °C and maintained for 2 hours. Upon completion of the reaction, it was cooled to room temperature, poured into saturated aqueous ammonium chloride solution (500 mL) and extracted with ethyl acetate (2 x 150 mL). The organic phases were combined and washed sequentially with aqueous sodium bicarbonate (NaHCO3) (2 × 150 mL), aqueous 1N hydrochloric acid (HCl) (2 × 150 mL) and brine (2 × 150 mL). The organic layer was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography (silica gel, 5% ethyl acetate/hexane). The target fractions were collected, combined and the solvent was removed under reduced pressure to give 2-hydroxy-4-iodobenzaldehyde (27 g, 79% yield) as a yellow solid. The salicylaldehyde derivative was of suitable purity and could be used directly in the subsequent reaction.
References
[1] Patent: WO2006/40676, 2006, A1. Location in patent: Page/Page column 51
[2] Patent: WO2004/87686, 2004, A2. Location in patent: Page 12-130
[3] Patent: WO2004/87687, 2004, A1. Location in patent: Page 12-130
[4] Patent: WO2006/40672, 2006, A1. Location in patent: Page/Page column 59
2-HYDROXY-4-IODO-BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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