2-HYDROXY-4-IODO-BENZALDEHYDE

Product Name: 2-HYDROXY-4-IODO-BENZALDEHYDE
CAS No.: 38170-02-4
Chemical Name: 2-HYDROXY-4-IODO-BENZALDEHYDE
Synonyms: 4-Iodo-2-hydroxybenzaldehyde;2-HYDROXY-4-IODO-BENZALDEHYDE;BENZALDEHYDE, 2-HYDROXY-4-IODO-
CBNumber: CB0668831
Molecular Formula: C7H5IO2
Formula Weight: 248.02
MOL File: Mol file

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2-HYDROXY-4-IODO-BENZALDEHYDE Property

Melting point:: 87 °C
Boiling point:: 290.0±30.0 °C(Predicted)
Density: 2.039±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 7.32±0.10(Predicted)
color: Off-White

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Safety

HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0354916
Product name: 2-HYDROXY-4-IODOBENZALDEHYDE
Purity: 95.00%
Packaging: 5MG
Price: $502.6
Updated: 2021/12/16

Abosyn

Product number: 61-10218
Product name: 2-Hydroxy-4-iodobenzaldehyde
Purity: 95-98%
Packaging: 1g
Price: $540
Updated: 2021/12/16

Labseeker

Product number: SC-62102
Product name: BENZALDEHYDE,2-HYDROXY-4-IODO-
Purity: 95
Packaging: 5g
Price: $1717
Updated: 2021/12/16

Crysdot

Product number: CD12076958
Product name: 2-Hydroxy-4-iodobenzaldehyde
Purity: 95%
Packaging: 250mg
Price: $125
Updated: 2021/12/16

Chemcia Scientific

Product number: CC00-2048
Product name: 2-Hydroxy-4-iodo-benzaldehyde
Purity: ＞98%
Packaging: 0.5g
Price: $175
Updated: 2021/12/16

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2-HYDROXY-4-IODO-BENZALDEHYDE Chemical Properties,Usage,Production

Uses

2-hydroxy-4-iodobenzaldehyde is used in the preparation of anti-B7-H3 antibodies.

Synthesis

50-00-0

533-58-4

38170-02-4

Step 1: Preparation of 2-hydroxy-4-iodobenzaldehyde Magnesium chloride (MgCl2, 19.5 g, 204 mmol) was added batchwise to a frozen solution of commercially available 2-iodophenol (30 g, 136 mmol) in acetonitrile (ACN) while keeping the reaction temperature below 10 °C. Paraformaldehyde (28.6 g, 954 mmol) and triethylamine (TEA, 76 mL, 545 mmol) were subsequently added and the reaction was exothermic to 15 °C. The reaction mixture was heated to 72 °C and maintained for 2 hours. Upon completion of the reaction, it was cooled to room temperature, poured into saturated aqueous ammonium chloride solution (500 mL) and extracted with ethyl acetate (2 x 150 mL). The organic phases were combined and washed sequentially with aqueous sodium bicarbonate (NaHCO3) (2 × 150 mL), aqueous 1N hydrochloric acid (HCl) (2 × 150 mL) and brine (2 × 150 mL). The organic layer was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography (silica gel, 5% ethyl acetate/hexane). The target fractions were collected, combined and the solvent was removed under reduced pressure to give 2-hydroxy-4-iodobenzaldehyde (27 g, 79% yield) as a yellow solid. The salicylaldehyde derivative was of suitable purity and could be used directly in the subsequent reaction.

References

[1] Patent: WO2006/40676, 2006, A1. Location in patent: Page/Page column 51
[2] Patent: WO2004/87686, 2004, A2. Location in patent: Page 12-130
[3] Patent: WO2004/87687, 2004, A1. Location in patent: Page 12-130
[4] Patent: WO2006/40672, 2006, A1. Location in patent: Page/Page column 59

2-HYDROXY-4-IODO-BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXY-4-IODO-BENZALDEHYDE Suppliers

China 60 Germany 1 India 2 United States 3 Global 66

SuZhou ShiYa Biopharmaceuticals, Inc.

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Bide Pharmatech Ltd.

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parabiochem

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Amadis Chemical Company Limited

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MQ (shanghai) Pharmaceuticals Co., Ltd.

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Aikon International Limited

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38170-02-4, 2-HYDROXY-4-IODO-BENZALDEHYDERelated Search:

2-METHOXY-4-(TRIFLUOROMETHOXY)BENZALDEHYDE 2-Bromo-3-fluoro-6-methoxybenzaldehyde 2-Fluoro-3,4-dimethoxy-benzaldehyde 2-methoxy-3-(trifluoromethoxy)benzaldehyde 2-CHLORO-3,6-DIFLUOROBENZALDEHYDE 2,5-Dibromo-3-fluorobenzaldehyde 2-bromo-6-chloro-4-fluorobenzaldehyde Benzaldehyde, 2-bromo-6-(difluoromethoxy)- 2-BROMO-4-FLUORO-6-METHYLBENZALDEHYDE 2-Fluoro-5-methylbenzaldehyde 2,4-DIFLUORO-3-METHOXYBENZALDEHYDE 2-bromo-5-methyl-4-nitrobenzaldehyde 3,4-Dichloro-5-(trifluoromethyl)benzaldehyde 2-bromo-3-fluoro-6-hydroxybenzaldehyde 2-Chloro-4-trifluoroMethoxy-benzaldehyde Cupric acetate monohydrate Salicylaldoxime Calcium chloride

2-HYDROXY-4-IODO-BENZALDEHYDE

BENZALDEHYDE, 2-HYDROXY-4-IODO-

4-Iodo-2-hydroxybenzaldehyde

38170-02-4