S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE
- Product Name
- S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE
- CAS No.
- 222638-67-7
- Chemical Name
- S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE
- Synonyms
- BEC HCl;Reaxys ID: 25974550;Methionine Impurity 19;BEC hydrochloride, 10 mM in DMSO;Methsuximide Impurity 1(Normesuximide);S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE;BEC hydrochloride - S-(2-Boronoethyl)-L-cysteine hydrochloride;(R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochloride;BEC HCl, 98%, a slow-binding and competitive Arginase II inhibitor;Inhibitor,NF-κB,hyperresponsiveness,metaplasia,inhibit,Arginase,BEC,BEC hydrochloride,Arginase-II,inflammation,CCL20
- CBNumber
- CB0669030
- Molecular Formula
- C5H13BClNO4S
- Formula Weight
- 229.48
- MOL File
- 222638-67-7.mol
S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H228Flammable solid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
N-Bromosuccinimide Price
- Product number
- 22145
- Product name
- BEC (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 22145
- Product name
- BEC (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- 22145
- Product name
- BEC (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $257
- Updated
- 2024/03/01
- Product number
- 22145
- Product name
- BEC (hydrochloride)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $469
- Updated
- 2024/03/01
- Product number
- B129600
- Product name
- BEC hydrochloride
- Packaging
- 1mg
- Price
- $105
- Updated
- 2021/12/16
S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Chemical Properties,Usage,Production
Description
BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 μM from kinetic analyses. It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively. It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.
Uses
BEC Hydrochloride is Arginase II inhibitor. For the biological study of the inhibition of arginase II, it prevented nitrate tolerance in human umbilical vein endothelial cell and in mouse aorta.
in vivo
Administration of the arginase inhibitor BEC decreases arginase activity and causes alterations in NO homeostasis, which are reflected by increases in S-nitrosylated and nitrated proteins in the lungs from inflamed mice. BEC enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and leads to further increases in airways hyperresponsiveness[3].
| Animal Model: | C57BL/6J wild-type mice, mice deficient in arginase 2 (Arg2-/-), mice deficient in both arginase 1 and 2 (Arg1-/-Arg2-/-), and mice deficient in NOX2 (NOX2-/- |
| Dosage: | 20 mg/kg. |
| Administration: | I.V., in 0.9% saline, 1 hour before the injection of LPS. |
| Result: | BEC robustly reduced VEGF expression in neuroglia (72% reduction) and macrophage/microglia (87% reduction). |
References
[1] NOEL N. KIM. Probing Erectile Function: S-(2-Boronoethyl)-l-Cysteine Binds to Arginase as a Transition State Analogue and Enhances Smooth Muscle Relaxation in Human Penile Corpus Cavernosum?,?[J]. Biochemistry Biochemistry, 2001, 40 9: 2678-2688. DOI: 10.1021/bi002317h
[2] DIANA M. COLLELUORI David E A. Classical and Slow-Binding Inhibitors of Human Type II Arginase?[J]. Biochemistry Biochemistry, 2001, 40 31: 9356-9362. DOI: 10.1021/bi010783g
S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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