ChemicalBook > CAS DataBase List > S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE

S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE

Product Name: S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE
CAS No.: 222638-67-7
Chemical Name: S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE
Synonyms: BEC HCl;Reaxys ID: 25974550;Methionine Impurity 19;BEC hydrochloride, 10 mM in DMSO;Methsuximide Impurity 1(Normesuximide);S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE;BEC hydrochloride - S-(2-Boronoethyl)-L-cysteine hydrochloride;(R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochloride;BEC HCl, 98%, a slow-binding and competitive Arginase II inhibitor;Inhibitor,NF-κB,hyperresponsiveness,metaplasia,inhibit,Arginase,BEC,BEC hydrochloride,Arginase-II,inflammation,CCL20
CBNumber: CB0669030
Molecular Formula: C5H13BClNO4S
Formula Weight: 229.48
MOL File: 222638-67-7.mol

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S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22145
Product name: BEC (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 22145
Product name: BEC (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 22145
Product name: BEC (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $257
Updated: 2024/03/01

Cayman Chemical

Product number: 22145
Product name: BEC (hydrochloride)
Purity: ≥95%
Packaging: 25mg
Price: $469
Updated: 2024/03/01

TRC

Product number: B129600
Product name: BEC hydrochloride
Packaging: 1mg
Price: $105
Updated: 2021/12/16

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S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with K_i values of 0.4 and 0.6 μM from kinetic analyses. It is also a potent inhibitor of human arginase II with K_i values of 310 and 30 nM at pH 7.5 and 9.5, respectively. It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.

Uses

BEC Hydrochloride is Arginase II inhibitor. For the biological study of the inhibition of arginase II, it prevented nitrate tolerance in human umbilical vein endothelial cell and in mouse aorta.

in vivo

Administration of the arginase inhibitor BEC decreases arginase activity and causes alterations in NO homeostasis, which are reflected by increases in S-nitrosylated and nitrated proteins in the lungs from inflamed mice. BEC enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and leads to further increases in airways hyperresponsiveness^[3].

Animal Model:	C57BL/6J wild-type mice, mice deficient in arginase 2 (Arg2^-/-), mice deficient in both arginase 1 and 2 (Arg1^-/-Arg2^-/-), and mice deficient in NOX2 (NOX2^-/-
Dosage:	20 mg/kg.
Administration:	I.V., in 0.9% saline, 1 hour before the injection of LPS.
Result:	BEC robustly reduced VEGF expression in neuroglia (72% reduction) and macrophage/microglia (87% reduction).

References

[1] NOEL N. KIM. Probing Erectile Function: S-(2-Boronoethyl)-l-Cysteine Binds to Arginase as a Transition State Analogue and Enhances Smooth Muscle Relaxation in Human Penile Corpus Cavernosum?,?[J]. Biochemistry Biochemistry, 2001, 40 9: 2678-2688. DOI: 10.1021/bi002317h
[2] DIANA M. COLLELUORI David E A. Classical and Slow-Binding Inhibitors of Human Type II Arginase?[J]. Biochemistry Biochemistry, 2001, 40 31: 9356-9362. DOI: 10.1021/bi010783g

S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Suppliers

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222638-67-7, S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDERelated Search:

L-Cysteine monohydrochloride S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE BEC

BEC HCl

BEC HCl, 98%, a slow-binding and competitive Arginase II inhibitor

S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE

BEC hydrochloride - S-(2-Boronoethyl)-L-cysteine hydrochloride

Reaxys ID: 25974550

(R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochloride

Inhibitor,NF-κB,hyperresponsiveness,metaplasia,inhibit,Arginase,BEC,BEC hydrochloride,Arginase-II,inflammation,CCL20

Methsuximide Impurity 1(Normesuximide)

BEC hydrochloride, 10 mM in DMSO

Methionine Impurity 19

222638-67-7

C5H12BNO4SClH

C5H13BClNO4S