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S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE

Product Name
S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE
CAS No.
222638-67-7
Chemical Name
S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE
Synonyms
BEC HCl;Reaxys ID: 25974550;Methionine Impurity 19;BEC hydrochloride, 10 mM in DMSO;Methsuximide Impurity 1(Normesuximide);S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE;BEC hydrochloride - S-(2-Boronoethyl)-L-cysteine hydrochloride;(R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochloride;BEC HCl, 98%, a slow-binding and competitive Arginase II inhibitor;Inhibitor,NF-κB,hyperresponsiveness,metaplasia,inhibit,Arginase,BEC,BEC hydrochloride,Arginase-II,inflammation,CCL20
CBNumber
CB0669030
Molecular Formula
C5H13BClNO4S
Formula Weight
229.48
MOL File
222638-67-7.mol
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S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22145
Product name
BEC (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
22145
Product name
BEC (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
22145
Product name
BEC (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$257
Updated
2024/03/01
Cayman Chemical
Product number
22145
Product name
BEC (hydrochloride)
Purity
≥95%
Packaging
25mg
Price
$469
Updated
2024/03/01
TRC
Product number
B129600
Product name
BEC hydrochloride
Packaging
1mg
Price
$105
Updated
2021/12/16
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S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 μM from kinetic analyses. It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively. It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances nitric oxide-dependent relaxation of human penile corpus cavernosum smooth muscle in vitro when used at concentrations ranging from 0.1 to 1 mM.

Uses

BEC Hydrochloride is Arginase II inhibitor. For the biological study of the inhibition of arginase II, it prevented nitrate tolerance in human umbilical vein endothelial cell and in mouse aorta.

in vivo

Administration of the arginase inhibitor BEC decreases arginase activity and causes alterations in NO homeostasis, which are reflected by increases in S-nitrosylated and nitrated proteins in the lungs from inflamed mice. BEC enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and leads to further increases in airways hyperresponsiveness[3].

Animal Model:C57BL/6J wild-type mice, mice deficient in arginase 2 (Arg2-/-), mice deficient in both arginase 1 and 2 (Arg1-/-Arg2-/-), and mice deficient in NOX2 (NOX2-/-
Dosage:20 mg/kg.
Administration:I.V., in 0.9% saline, 1 hour before the injection of LPS.
Result:BEC robustly reduced VEGF expression in neuroglia (72% reduction) and macrophage/microglia (87% reduction).

References

[1] NOEL N. KIM. Probing Erectile Function: S-(2-Boronoethyl)-l-Cysteine Binds to Arginase as a Transition State Analogue and Enhances Smooth Muscle Relaxation in Human Penile Corpus Cavernosum?,?[J]. Biochemistry Biochemistry, 2001, 40 9: 2678-2688. DOI: 10.1021/bi002317h
[2] DIANA M. COLLELUORI  David E A. Classical and Slow-Binding Inhibitors of Human Type II Arginase?[J]. Biochemistry Biochemistry, 2001, 40 31: 9356-9362. DOI: 10.1021/bi010783g

S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE Suppliers

China 67 India 1 United States 10 Global 78
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
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222638-67-7, S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDERelated Search:

L-Cysteine monohydrochloride S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE BEC

  • BEC HCl
  • BEC HCl, 98%, a slow-binding and competitive Arginase II inhibitor
  • S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE
  • BEC hydrochloride - S-(2-Boronoethyl)-L-cysteine hydrochloride
  • Reaxys ID: 25974550
  • (R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochloride
  • Inhibitor,NF-κB,hyperresponsiveness,metaplasia,inhibit,Arginase,BEC,BEC hydrochloride,Arginase-II,inflammation,CCL20
  • Methsuximide Impurity 1(Normesuximide)
  • BEC hydrochloride, 10 mM in DMSO
  • Methionine Impurity 19
  • 222638-67-7
  • C5H12BNO4SClH
  • C5H13BClNO4S