Imidazol-1-yl-acetic acid
- Product Name
- Imidazol-1-yl-acetic acid
- CAS No.
- 22884-10-2
- Chemical Name
- Imidazol-1-yl-acetic acid
- Synonyms
- 2-(1H-IMIDAZOL-1-YL)ACETIC ACID;1H-IMIDAZOLE-1-ACETIC ACID;Imidazole-1-acetic acid;1H-Imidazole-1-acetic;IMidazole-1-yl-acetic acid;(1-ImidazoL;AKOS MSC-0001;VITAS-BB TBB000646;CHEMBRDG-BB 4400175;TIMTEC-BB SBB010182
- CBNumber
- CB0675060
- Molecular Formula
- C5H6N2O2
- Formula Weight
- 126.11
- MOL File
- 22884-10-2.mol
Imidazol-1-yl-acetic acid Property
- Melting point:
- 258 °C
- Boiling point:
- 392.1±25.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Water (Slightly)
- pka
- 3.37±0.10(Predicted)
- form
- Solid
- color
- White to Pale Beige
- InChI
- InChI=1S/C5H6N2O2/c8-5(9)3-7-2-1-6-4-7/h1-2,4H,3H2,(H,8,9)
- InChIKey
- QAFBDRSXXHEXGB-UHFFFAOYSA-N
- SMILES
- C1N(CC(O)=O)C=CN=1
- CAS DataBase Reference
- 22884-10-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-41-37/38
- Safety Statements
- 26-39
- HazardClass
- IRRITANT
- HS Code
- 2933399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- Y0002011
- Product name
- Zoledronic acid impurity A
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 15 mg
- Price
- $155
- Updated
- 2025/07/31
- Product number
- PHR2459
- Product name
- Zoledronic Acid Related Compound A
- Purity
- PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial
- Packaging
- 50MG
- Price
- $863
- Updated
- 2025/07/31
- Product number
- 1724838
- Product name
- Zoledronic acid Related Compound A
- Packaging
- 30mg
- Price
- $1300
- Updated
- 2025/07/31
- Product number
- I0670
- Product name
- 1-Imidazoleacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- I0670
- Product name
- 1-Imidazoleacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $90
- Updated
- 2025/07/31
Imidazol-1-yl-acetic acid Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
An impurity arising in the synthesis of zoledronic acid (Z623500).
Definition
ChEBI: Imidazol-1-ylacetic acid is an imidazolyl carboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by an imidazol-1-yl group. It has a role as a metabolite. It is functionally related to an acetic acid.
Synthesis
83468-75-1
22884-10-2
The general procedure for the synthesis of (1-imidazolyl)acetic acid from the compound (CAS: 83468-75-1) was as follows: first, water (15.1 kg) was added to the reactor, followed by removal of chloroform by distillation, controlling the jacket temperature at 60-65 °C (boiling point of the azeotrope is 53 °C) and returning the aqueous phase back to the reactor by using a Dean-Stark water separator. After the chloroform is completely removed, the reactor jacket temperature is slowly raised to 115°C, at which point the tert-butanol and water form an azeotrope (boiling point of 80°C) that is distilled out. After the alcohol was completely removed, the remaining aqueous solution was cooled to room temperature and then drained from the reactor, resulting in 17.54 kg of solution containing (1-imidazolyl)acetic acid. The actual amount of (1-imidazolyl)acetic acid in the solution was determined by NMR to be 3.77 kg (29.9 mol) in 82.2% yield.
References
[1] Patent: WO2007/109542, 2007, A2. Location in patent: Page/Page column 4; 6
Imidazol-1-yl-acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Imidazol-1-yl-acetic acid manufacturers
- Product
- Imidazol-1-yl-acetic acid 22884-10-2
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-22
- Product
- Imidazol-1-ylacetic acid 22884-10-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 1 tons
- Release date
- 2025-04-14
- Product
- Imidazol-1-yl-acetic acid 22884-10-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-13