DAMNACANTHAL

Product Name: DAMNACANTHAL
CAS No.: 477-84-9
Chemical Name: DAMNACANTHAL
Synonyms: DAMNACANTAL;DAMNACANTHAL;3-HYDROXY-1-METHOXYANTHRAQUINONE-2-ALDEHYDE;1-Methoxy-2-formyl-3-hydroxy-9,10-anthraquinone;3-Hydroxy-1-Methoxy-2-anthraquinonecarboxaldehyde;1-Methoxy-3-hydroxy-9,10-dioxoanthracene-2-carbaldehyde;3-hydroxy-1-methoxy-9,10-dioxoanthracene-2-carbaldehyde;3-hydroxy-1-methoxy-9,10-dioxo-anthracene-2-carbaldehyde;3-hydroxy-9,10-diketo-1-methoxy-anthracene-2-carbaldehyde;9,10-Dihydro-3-hydroxy-1-Methoxy-9,10-dioxo-2-anthraldehyde
CBNumber: CB0681393
Molecular Formula: C16H10O5
Formula Weight: 282.25
MOL File: 477-84-9.mol

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DAMNACANTHAL Property

Melting point:: 218～219℃
Boiling point:: 531.9±50.0 °C(Predicted)
Density: 1.461±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 7 mg/ml)
pka: 5.26±0.20(Predicted)
form: Pale orange solid.
color: Yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 251650
Product name: Damnacanthal - CAS 477-84-9 - Calbiochem
Packaging: 1mg
Price: $272
Updated: 2024/03/01

Tocris

Product number: 1936
Product name: Damnacanthal
Purity: ≥98%(HPLC)
Packaging: 1
Price: $175
Updated: 2021/12/16

TRC

Product number: D134800
Product name: Damnacanthal
Packaging: 5mg
Price: $185
Updated: 2021/12/16

Usbiological

Product number: 255101
Product name: Damnacanthal
Packaging: 1mg
Price: $432
Updated: 2021/12/16

Usbiological

Product number: 007491
Product name: Damnacanthal
Packaging: 5mg
Price: $496
Updated: 2021/12/16

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DAMNACANTHAL Chemical Properties,Usage,Production

Description

Damnacanthal (477-84-9) is a potent inhibitor of p56lck?tyrosine kinase activity (IC50?= 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn?and p60src?tyrosine kinases and > 40-fold to 100-fold selectivity over other kinases.1?Mobilizes intracellular Ca2+?in dermal fibroblasts.2?Inhibits LIM-kinase, impairing cell migration and invasion.3?A potent inhibitor of angiogenesis.4?Inhibits mast cell activation.5

Uses

Damnacanthal-induced anti-inflammation is associated with inhibition of NF-κB activity. Damnacanthal is used in the treatment of inflammatory-related diseases.

Definition

ChEBI: 3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde is a monohydroxyanthraquinone and an aldehyde.

target

References

1) Faltynek?et al.?(1995),?Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity; Biochemistry,?34?12404 2) Aoki?et al.?(2000),?Mechanism of damnacanthal-induced ;Ca(2+)](i) elevation in human dermal fibroblasts; Eur. J. Pharmacol.,?387?119 3) Ohashi?et al.?(2014),?Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion; Mol. Biol. Cell,?25?828 4) Garcia-Vilas?et al.?(2017),?The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects; Cancer Letters,?385?1 5) Garcia-Vilas?et al.?(2015),?Damnacanthal inhibits IgE receptor-mediated activation of mast cells; Mol. Immunol.,?65?86

DAMNACANTHAL Preparation Products And Raw materials

Raw materials

Preparation Products

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DAMNACANTHAL Suppliers

China 75 Germany 1 Switzerland 1 United Kingdom 3 United States 9 Global 89

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477-84-9, DAMNACANTHALRelated Search:

BORRELIDIN (BETA,BETA-DIMETHYLACRYL)SHIKONIN Emodin 8-glucoside PLUMBAGIN Emodin-8-glucoside Chrysophanic acid PURPURIN Chrysophal 8-O-glucoside Chrysophanein AURANTIO-OBTUSIN Epimedium P.E Icariin 10%,20% HPLC 1-methoxyanthraquinone 1,3-DIHYDROXY-2-METHYLANTHRAQUINONE 2,6-DIHYDROXY-4-METHYLBENZALDEHYDE 1-(4-HYDROXY-2,5-DIMETHYL-PHENYL)-ETHANONE 2,4-DIHYDROXY-BENZENE-1,3-DICARB-ALDEHYDE DAMNACANTHAL DAMNACANTHAL(RG)

DAMNACANTHAL

DAMNACANTAL

1-Methoxy-2-formyl-3-hydroxy-9,10-anthraquinone

1-Methoxy-3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carbaldehyde

3-HYDROXY-1-METHOXYANTHRAQUINONE-2-ALDEHYDE

9,10-Dihydroxy-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde

1-Methoxy-3-hydroxy-9,10-dioxoanthracene-2-carbaldehyde

9,10-Dihydro-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarbaldehyde

3-hydroxy-1-methoxy-9,10-dioxo-anthracene-2-carbaldehyde

3-hydroxy-1-methoxy-9,10-dioxoanthracene-2-carbaldehyde

3-hydroxy-9,10-diketo-1-methoxy-anthracene-2-carbaldehyde

3-Hydroxy-1-Methoxy-2-anthraquinonecarboxaldehyde

9,10-Dihydro-3-hydroxy-1-Methoxy-9,10-dioxo-2-anthracenecarboxaldehyde

9,10-Dihydro-3-hydroxy-1-Methoxy-9,10-dioxo-2-anthraldehyde

2-Anthracenecarboxaldehyde,9,10-dihydro-3-hydroxy-1-methoxy-9,10-dioxo-

477-84-9