Chrysophanic acid
- Product Name
- Chrysophanic acid
- CAS No.
- 481-74-3
- Chemical Name
- Chrysophanic acid
- Synonyms
- CHRYSOPHANOL;RHUBARB EXTRACT;M13;Chrysophal;SEMEN CASSIAE EXTRACT;3-METHYLCHRYSAZIN;M 13;M-13;c.i.75400;NSC 37132
- CBNumber
- CB9760903
- Molecular Formula
- C15H10O4
- Formula Weight
- 254.24
- MOL File
- 481-74-3.mol
Chrysophanic acid Property
- Melting point:
- 194-198 °C
- Boiling point:
- 357.45°C (rough estimate)
- Density
- 1.2693 (rough estimate)
- refractive index
- 1.4872 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- chloroform: soluble1%
- form
- crystalline
- pka
- 6.63±0.20(Predicted)
- color
- yellow-orange
- Water Solubility
- <0.1 g/100 mL at 18 ºC
- λmax
- 429nm(MeOH)(lit.)
- Merck
- 14,2258
- BRN
- 1252300
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- LogP
- 4.720 (est)
- CAS DataBase Reference
- 481-74-3(CAS DataBase Reference)
- EPA Substance Registry System
- Chrysophanic acid (481-74-3)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/38-36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- CB6725000
- F
- 8-10
- HS Code
- 29146990
- Hazardous Substances Data
- 481-74-3(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 229075
- Product name
- 1,8-Dihydroxy-3-methylanthraquinone
- Purity
- 98%
- Packaging
- 50mg
- Price
- $115
- Updated
- 2025/07/31
- Product number
- PHL89378
- Product name
- Chrysophanol
- Purity
- phyproof<SUP>®</SUP> Reference Substance
- Packaging
- 25 mg
- Price
- $316
- Updated
- 2025/07/31
- Product number
- 229075
- Product name
- 1,8-Dihydroxy-3-methylanthraquinone
- Purity
- 98%
- Packaging
- 1g
- Price
- $936
- Updated
- 2025/07/31
- Product number
- C2505
- Product name
- Chrysophanic Acid
- Purity
- >96.0%(HPLC)
- Packaging
- 100mg
- Price
- $92
- Updated
- 2025/07/31
- Product number
- 19870
- Product name
- Chrysophanol
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $32
- Updated
- 2024/03/01
Chrysophanic acid Chemical Properties,Usage,Production
Description
Chrysophanol is an anthraquinone that has been found in R. palmatum and has diverse biological activities. It induces necrosis in J5 human liver cancer cells when used at concentrations of 25, 50, 75, 100, and 200 μM. Chrysophanol (5, 10, and 50 μM) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; ) and inhibits LPS-induced DNA oxidation in BV-2 microglia. In vivo, chrysophanol (5 mg/kg) decreases colonic levels of IL-6 and activation of NF-κB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of colitis induced by dextran sulfate (DSS; ). Chrysophanol (0.1, 1, and 10 mg/kg) increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).
Chemical Properties
yellow crystalline solid or brown powder
Uses
Chrysophanic acid, a natural anthraquinone, is used to study anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells 1. It is also used to study the inhibition of replication of poliovirus types 2 and 3 (Picornaviridae) in vitro 2.
Uses
antineoplastic, antibacterial
Uses
A topical ointment used in the treatment of dermal conditions such as eczema and herpes.
Definition
ChEBI: A trihydroxyanthraquinone that is chrysazin with a methyl substituent at C-3. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity.
Synthesis Reference(s)
Tetrahedron Letters, 20, p. 4911, 1979 DOI: 10.1016/S0040-4039(01)86747-2
General Description
Golden yellow plates or brown powder. Melting point 196°C. Slightly soluble in water. Pale yellow aqueous solutions turn red on addition of alkali. Solutions in concentrated sulfuric acid are red.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Chrysophanic acid is incompatible with strong oxidizing agents.
Fire Hazard
Flash point data for Chrysophanic acid are not available; however, Chrysophanic acid is probably combustible.
Purification Methods
Crystallise chrysophanic acid from EtOH or *benzene and has m 195.6-196.2o, after sublimation it in a vacuum. The yellow mono-acetate has m 188-190o (from MeOH or Me2CO). It forms Ni2+, Co2+ and Cu2+ complexes. [Beilstein 8 H 470, 8 I 725, 8 II 510, 8 III 3808, 8 IV 3277.]
References
[1] F H QI. Traditional Chinese medicine and related active compounds: a review of their role on hepatitis B virus infection.[J]. Drug Discoveries and Therapeutics, 2013, 7 6: 212-224. DOI: 10.5582/ddt.2013.v7.6.212
[2] CHI-CHENG LU. Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells[J]. Molecular Nutrition & Food Research, 2010, 54 7: 967-976. DOI: 10.1002/mnfr.200900265
[3] FUQING LIN. Chrysophanol affords neuroprotection against microglial activation and free radical-mediated oxidative damage in BV2 murine microglia.[J]. International journal of clinical and experimental medicine, 2015, 8 3: 3447-3455.
[4] SU-JIN KIM. Anti-Inflammatory activity of chrysophanol through the suppression of NF-kappaB/caspase-1 activation in vitro and in vivo.[J]. Molecules, 2010, 15 9: 6436-6451. DOI: 10.3390/molecules15096436
[5] YONGMEI ZHAO . Neuroprotective effects of Chrysophanol against inflammation in middle cerebral artery occlusion mice[J]. Neuroscience Letters, 2016, 630: Pages 16-22. DOI: 10.1016/j.neulet.2016.07.036
Chrysophanic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Chrysophanic acid Suppliers
- Tel
- 0851-8475-2296 18096062265
- Fax
- 0851-84752205
- 646585516@qq.com
- Country
- China
- ProdList
- 2778
- Advantage
- 58
- Tel
- 13186333400
- m13108465082@163.com
- Country
- China
- ProdList
- 886
- Advantage
- 58
- Tel
- 13186333400
- cuichengbio@163.com
- Country
- China
- ProdList
- 4859
- Advantage
- 58
- Tel
- 4001-009266 17349750668
- product@sci-e.com
- Country
- China
- ProdList
- 2808
- Advantage
- 58
- Tel
- 025-84430028 13815430202
- sale02@cqherb.com
- Country
- China
- ProdList
- 294
- Advantage
- 59
- Tel
- 029-029-86629612 18202932191
- sales3@pioneerbiotech.com
- Country
- China
- ProdList
- 300
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6003
- Advantage
- 61
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
View Lastest Price from Chrysophanic acid manufacturers
- Product
- Chrysophanol 481-74-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2025-05-07
- Product
- Chrysophanol 481-74-3
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-12-10
- Product
- Chrysophanol 481-74-3
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-10-08