Z-ASP-OME
- Product Name
- Z-ASP-OME
- CAS No.
- 4668-42-2
- Chemical Name
- Z-ASP-OME
- Synonyms
- Z-ASP-OME;CBZ-ASP-OME;Z-L-ASP-OME;Cbz-L-Asp-OMe;Z-ASPARTIC ACID-OME;Z-ASP-OME USP/EP/BP;1-Methyl N-Cbz-L-aspartate;Z-L-ASPARTIC ACID A-METHYLESTER;Z-L-ASPARTIC ACID 1-METHYL ESTER;Cbz -L-asparticacidα-methylester
- CBNumber
- CB0698108
- Molecular Formula
- C13H15NO6
- Formula Weight
- 281.26
- MOL File
- 4668-42-2.mol
Z-ASP-OME Property
- Melting point:
- 89.0 to 93.0 °C
- Boiling point:
- 498.9±45.0 °C(Predicted)
- Density
- 1.304±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 4.09±0.19(Predicted)
- color
- White to Almost white
- BRN
- 4813538
- CAS DataBase Reference
- 4668-42-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/22-37-41
- Safety Statements
- 26-36
- WGK Germany
- 3
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 95998
- Product name
- Z-Asp-OMe
- Purity
- ≥98.0% (TLC)
- Packaging
- 5g
- Price
- $415
- Updated
- 2023/06/20
- Product number
- M2707
- Product name
- 1-Methyl N-Carbobenzoxy-L-aspartate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $99
- Updated
- 2025/07/31
- Product number
- M2707
- Product name
- 1-Methyl N-Carbobenzoxy-L-aspartate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $390
- Updated
- 2025/07/31
- Product number
- C227948
- Product name
- N-Cbz-L-AsparticAcid1-MethylEster
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C227948
- Product name
- N-Cbz-L-AsparticAcid1-MethylEster
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
Z-ASP-OME Chemical Properties,Usage,Production
Uses
peptide synthesis
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
67-56-1
4515-23-5
4668-42-2
The general procedure for the synthesis of (S)-3-(((benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutanoic acid from methanol and Z-aspartic anhydride was as follows: 49.0 g (196 mmol) of benzyl (S)-(2,5-dioxo-tetrahydrofuran-3-yl)carbamate obtained from Steps 1-1 (2) was dissolved in 100 mL of ethyl acetate, followed by adding 150 mL of methanol and the reaction was stirred at room temperature for 5 hours. Upon completion of the reaction, the mixture was concentrated to dryness under reduced pressure and the resulting residue was dissolved in 200 mL of diisopropyl ether. 34 mL of dicyclohexylamine was added slowly and dropwise with stirring to produce (S)-3-((benzyloxycarbonyl)amino)-4-methoxy-4-oxobutanoic acid dicyclohexylamine salt. The salt was collected by filtration and suspended in 200 mL of distilled water. 200 mL of ethyl acetate was added and the pH was adjusted with 6N hydrochloric acid to 2. After phase separation was carried out, the organic layer was washed several times with distilled water, dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. To the concentrated residue 200 mL of diethyl ether and 20 mL of petroleum ether were added to promote crystallization. The resulting crystals were filtered to give 32.3 g of (S)-3-(((benzyloxy)carbonyl)amino)-4-methoxy-4-oxobutanoic acid in 54% yield. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.37 (m, 5H), 5.76 (d, 1H), 5.13 (s, 1H), 4.65 (m, 1H), 3.76 (s, 2H), 3.00 (dd, 2H).
References
[1] Patent: WO2012/148246, 2012, A2. Location in patent: Page/Page column 13
Z-ASP-OME Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Z-ASP-OME manufacturers
- Product
- Z-ASP-OME 4668-42-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Z-ASP-OME 4668-42-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2019-08-31