Ipriflavone
- Product Name
- Ipriflavone
- CAS No.
- 35212-22-7
- Chemical Name
- Ipriflavone
- Synonyms
- Ipriavone;Ipriflavon;7-ISOPROPOXYISOFLAVONE;Ipriflavone (Osteofix);tc80;osten;fl113;osteofix;YAMBOLAP;Iprosten
- CBNumber
- CB0698496
- Molecular Formula
- C18H16O3
- Formula Weight
- 280.32
- MOL File
- 35212-22-7.mol
Ipriflavone Property
- Melting point:
- 116-120 °C(lit.)
- Boiling point:
- 363.04°C (rough estimate)
- Density
- 1.2170 (rough estimate)
- refractive index
- 1.4700 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMF:20.0(Max Conc. mg/mL);71.35(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.71(Max Conc. mM)
DMSO:33.11(Max Conc. mg/mL);118.11(Max Conc. mM)
Ethanol:1.5(Max Conc. mg/mL);5.35(Max Conc. mM) - form
- powder to crystal
- color
- White to Almost white
- Merck
- 14,5074
- InChI
- InChI=1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3
- InChIKey
- SFBODOKJTYAUCM-UHFFFAOYSA-N
- SMILES
- C1OC2=CC(OC(C)C)=CC=C2C(=O)C=1C1=CC=CC=C1
- LogP
- 4.245 (est)
- CAS DataBase Reference
- 35212-22-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-36/37/39-27-26
- WGK Germany
- 2
- RTECS
- DJ3100500
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 381551
- Product name
- 7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $99.2
- Updated
- 2024/03/01
- Product number
- 16499
- Product name
- Ipriflavone
- Purity
- analytical standard
- Packaging
- 100mg
- Price
- $92
- Updated
- 2022/05/15
- Product number
- I0669
- Product name
- Ipriflavone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $47
- Updated
- 2024/03/01
- Product number
- I0669
- Product name
- Ipriflavone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $138
- Updated
- 2024/03/01
- Product number
- 26319
- Product name
- Ipriflavone
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
Ipriflavone Chemical Properties,Usage,Production
Description
Ipriflavone, a derivative of isoflavone, is a calcium metabolism regulator useful in the treatment of primary and secondary osteoporosis, as well as disorders of osteogenesis. It appears to be without significant side-effects.
Chemical Properties
white powder
Originator
Chinoin (Japan)
Uses
7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one (Ipriflavone) has been used as a model drug in a study to functionalize the mesoporous bioactive glasses (MBG). Study suggested that since ipriflavone is a hydrophobic anti-osteoporotic drug, it easily attaches to the surface of MBG and results in long-term drug delivery.
Uses
anabolic
Definition
ChEBI: Ipriflavone is a member of the class of isoflavones that is isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. A synthetic isoflavone, it was formerly used for the treatment of osteoporosis, although a randomised controlled study failed to show any benefit. It is still used to prevent osteoporosis in post-menopausal women. It has a role as a bone density conservation agent. It is a member of isoflavones and an aromatic ether.
brand name
Osten
benefits
Ipriflavone is used clinically to treat osteoporosis. Bodybuilders also use ipriflavone, but enough experimental data supports this purpose. It has been shown to have anti-inflammatory and antioxidant activity. It helps to reduce bone loss, increase bone density, and reduce the risk of developing osteoporosis. It has also been found to help reduce neuroinflammation . In addition, it has been found to help reduce the risk of certain types of cancer, improve cognitive function and reduce the risk of depression.
General Description
7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one (Ipriflavone), a synthetic flavonoid, is reported to stimulate the activity of osteoblasts. It is reported to promote the deposition of calcium and the formation of mineralized nodules by newborn rat calvarial osteoblast-like (ROB) cells as well as the activity of alkaline phosphatase. Ipriflavone, an isoflavone derivative, is a new drug used to decrease bone loss in osteoporosis.
Side effects
Ipriflavone should be taken under medical supervision only. It can produce side effects such as stomach pain, diarrhoea, dizziness, etc. It may have a sudden increase in the WBC count if administered for six months or more. When the treatment with Ipriflavone is on, it is suggested that the WBC count should be monitored.
in vitro
Ipriflavone inhibits the proliferation and DNA synthesis of MDA-231 cells and blocks the ligand-induced phosphorylation of Tyr(845) of the EGFR. Ipriflavone does not promote apoptosis of MDA-231 cells. Ipriflavone also promotes the deposition of calcium and the formation of mineralized nodules by newborn rat calvarial osteoblast-like cells as well as the activity of alkaline phosphatase.
in vivo
Ipriflavone ameliorated the host inflammatory response associated with activation of NLRP3 inflammasomes at the implantation site, which was characterised by inflammatory cell infiltration and reduced levels of the pro-inflammatory cytokine interleukin-1β. Daily oral administration of ipriflavone at 12 mg/mouse significantly inhibits the development of new osteolytic bone metastases and the progression of established osteolytic lesions, prolonging the life of tumor-bearing mice. Ipriflavone reduces the number of osteoclasts at the bone-cancer interface with no severe adverse effects on the host. 1-month treatment with ipriflavone increases bone density and improves the biomechanical properties of adult rat male bones without altering mineral composition.
Ipriflavone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ipriflavone manufacturers
- Product
- Ipriflavone 35212-22-7
- Price
- US $145.00-65.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-12-25
- Product
- Ipriflavone 35212-22-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- ≥98% HPLC
- Supply Ability
- 1000KG
- Release date
- 2022-09-22
- Product
- Ipriflavone 35212-22-7
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- More than 99%
- Supply Ability
- 2000KG/MONTH
- Release date
- 2024-04-22