Eprinomectin
- Product Name
- Eprinomectin
- CAS No.
- 123997-26-2
- Chemical Name
- Eprinomectin
- Synonyms
- Emamectin B1 Benzoate;eprinex;Eprinomectin (Mixture of B1a and B1b);MK 397;EPRINOMECTIN;Eprinomection;EprinomectinB1;Acetaminobamectin;Acetaminoabamectin;acetamido abamectin
- CBNumber
- CB2316329
- Molecular Formula
- C50H75NO14
- Formula Weight
- 914.1288
- MOL File
- 123997-26-2.mol
Eprinomectin Property
- Melting point:
- 163-166°C
- Density
- 1.23
- Flash point:
- 2 °C
- storage temp.
- 2-8°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
- form
- Solid
- color
- White to off-white
- Stability:
- Hygroscopic
Safety
- Hazard Codes
- F,Xn,N,T
- Risk Statements
- 11-20/21/22-36-62-50/53-25-63
- Safety Statements
- 26-36/37-16-61-60-45
- RIDADR
- UN 2811
- WGK Germany
- 3
- HS Code
- 2941906000
- Toxicity
- LD50 orally in mice: 24 mg/kg (Jones)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H361Suspected of damaging fertility or the unborn child
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P273Avoid release to the environment.
N-Bromosuccinimide Price
- Product number
- 32526
- Product name
- Eprinomectin
- Purity
- PESTANAL
- Packaging
- 100mg
- Price
- $238
- Updated
- 2024/03/01
- Product number
- 1237752
- Product name
- Eprinomectin
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 300mg
- Price
- $678
- Updated
- 2024/03/01
- Product number
- 28182
- Product name
- Eprinomectin
- Packaging
- 50mg
- Price
- $66
- Updated
- 2023/06/20
- Product number
- 28182
- Product name
- Eprinomectin
- Packaging
- 100mg
- Price
- $118
- Updated
- 2023/06/20
- Product number
- PHR1766
- Product name
- Eprinomectin
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 1g
- Price
- $180
- Updated
- 2024/03/01
Eprinomectin Chemical Properties,Usage,Production
Description
Eprinomectin is a semisynthetic avermectin that consists of a mixture of two homologues, eprinomectin B1a (4 epi-acetylamino-4 -deoxy-avermectin B1; 90%) and eprinomectin B1b (10%).Eprinomectin was developed as a topical endectocide for all categories of cattle including lactating dairy cattle, and the process by which eprinomectin was selected for further development has been described (90). Briefly, several hundred avermectin/ milbemycin analogues were screened in a sheep model for efficacy against a range of endoparasites and in lactating dairy cows for a low milk:plasma partitioning ratio. Themilk:plasma ratio for eprinomectin is <0.2; ivermectin, by comparison, partitions equally between milk and plasma.
Description
Eprinomectin is an avermectin with anthelmintic and insecticidal activities. It is comprised of eprinomectin B1a and eprinomectin B1b . Eprinomectin (≥0.08 mg/kg, applied topically) reduces worm burden by 99% or more in bovine models of adult H. placei, O. ostertagi, T. axei, Cooperia punctata, N. helvetianus, O. radiatum, or D. viviparus infection. It also reduces parasite burden in bovine models of horn fly (H. irritans) or mange mite (C. bovis) infestation, as well as in cows naturally infested with lice (L. vituli), when applied topically at doses ranging from 0.16 to 0.5 mg/kg. Formulations containing eprinomectin have been used in the treatment and control of a variety of endo- and ectoparasites in cattle.
Chemical Properties
Crystalline Solid
Uses
A mixture of semi-synthetic Avermectins; containing 90% or more of component B1a and 10% or less of component B1b. Antiparasitic
Uses
Eprinomectin is a mixture of eprinomectins B1a and B1b in a 9:1 ratio, produced from a mixture of avermectin B1a and B1b. Eprinomectin is used commercially as a topical endectocide (insecticide, miticide and nematocide) for cattle, including lactating dairy cows. Like all avermectins and milbemycins, eprinomectin acts by binding to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite, mite or insect.
Uses
A mixture of Eprinomectin B1a and B1b showing anti-anthelintic activity
brand name
Eprinex [Veterinary](Merial).
Veterinary Drugs and Treatments
In cattle, eprinomectin is indicated for a variety gastrointestinal
roundworms including
adult and L4 stages of Haemonchus placei,
Ostertagia ostertagi, Trichostrongylus axei and colubriformis,
Cooperia oncophora/punctata/surnabada, Nematodirus helvetianus,
Oesophagostomum radiatum, Bunostomum phlebotomum, and
Trichuris spp. (adults only); cattle grubs; lice; mange mites; horn
flies (for 7 days after treatment), and lungworms (Dictyocaulus
vivaparus—for 21 days after treatment).
Topical eprinomectin may be useful for the topical treatment
of ear mites (Psoroptes cuniculi) in rabbits. One small study (6 subjects)
showed partial response when rabbits were dosed at 5 mg/kg
topically, twice at 14 day intervals. (Ulutas, Voyvoda et al. 2005)
Toxicity evaluation
Acute oral LD50 for rats: 55mg/kg
Eprinomectin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Eprinomectin manufacturers
- Product
- EPRINOMECTIN 123997-26-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 95.0%
- Supply Ability
- 1tons
- Release date
- 2024-04-26
- Product
- Eprinomectin 123997-26-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 100kg
- Release date
- 2021-10-21
- Product
- Eprinomectin 123997-26-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- CP2015
- Supply Ability
- 20tons
- Release date
- 2023-09-20