Eprinomectin

ChemicalBook > CAS DataBase List > Eprinomectin

Product Name: Eprinomectin
CAS No.: 123997-26-2
Chemical Name: Eprinomectin
Synonyms: Emamectin B1 Benzoate;eprinex;Eprinomectin (Mixture of B1a and B1b);MK 397;EPRINOMECTIN;Eprinomection;EprinomectinB1;Acetaminobamectin;Acetaminoabamectin;acetamido abamectin
CBNumber: CB2316329
Molecular Formula: C50H75NO14
Formula Weight: 914.1288
MOL File: 123997-26-2.mol

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Eprinomectin Property

Melting point:: 163-166°C
Density: 1.23
Flash point:: 2 °C
storage temp.: 2-8°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form: Solid
color: White to off-white
Stability:: Hygroscopic

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Safety

Hazard Codes: F,Xn,N,T
Risk Statements: 11-20/21/22-36-62-50/53-25-63
Safety Statements: 26-36/37-16-61-60-45
RIDADR: UN 2811
WGK Germany: 3
HS Code: 2941906000
Toxicity: LD50 orally in mice: 24 mg/kg (Jones)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H361Suspected of damaging fertility or the unborn child

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 32526
Product name: Eprinomectin
Purity: PESTANAL
Packaging: 100mg
Price: $238
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1237752
Product name: Eprinomectin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 300mg
Price: $678
Updated: 2024/03/01

Cayman Chemical

Product number: 28182
Product name: Eprinomectin
Packaging: 50mg
Price: $66
Updated: 2023/06/20

Cayman Chemical

Product number: 28182
Product name: Eprinomectin
Packaging: 100mg
Price: $118
Updated: 2023/06/20

Sigma-Aldrich

Product number: PHR1766
Product name: Eprinomectin
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1g
Price: $180
Updated: 2024/03/01

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Eprinomectin Chemical Properties,Usage,Production

Description

Eprinomectin is a semisynthetic avermectin that consists of a mixture of two homologues, eprinomectin B1a (4 epi-acetylamino-4 -deoxy-avermectin B1; 90%) and eprinomectin B1b (10%).Eprinomectin was developed as a topical endectocide for all categories of cattle including lactating dairy cattle, and the process by which eprinomectin was selected for further development has been described (90). Briefly, several hundred avermectin/ milbemycin analogues were screened in a sheep model for efficacy against a range of endoparasites and in lactating dairy cows for a low milk:plasma partitioning ratio. Themilk:plasma ratio for eprinomectin is <0.2; ivermectin, by comparison, partitions equally between milk and plasma.

Description

Eprinomectin is an avermectin with anthelmintic and insecticidal activities. It is comprised of eprinomectin B_1a and eprinomectin B_1b . Eprinomectin (≥0.08 mg/kg, applied topically) reduces worm burden by 99% or more in bovine models of adult H. placei, O. ostertagi, T. axei, Cooperia punctata, N. helvetianus, O. radiatum, or D. viviparus infection. It also reduces parasite burden in bovine models of horn fly (H. irritans) or mange mite (C. bovis) infestation, as well as in cows naturally infested with lice (L. vituli), when applied topically at doses ranging from 0.16 to 0.5 mg/kg. Formulations containing eprinomectin have been used in the treatment and control of a variety of endo- and ectoparasites in cattle.

Chemical Properties

Crystalline Solid

Uses

A mixture of semi-synthetic Avermectins; containing 90% or more of component B1a and 10% or less of component B1b. Antiparasitic

Uses

Eprinomectin is a mixture of eprinomectins B1a and B1b in a 9:1 ratio, produced from a mixture of avermectin B1a and B1b. Eprinomectin is used commercially as a topical endectocide (insecticide, miticide and nematocide) for cattle, including lactating dairy cows. Like all avermectins and milbemycins, eprinomectin acts by binding to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite, mite or insect.

Uses

A mixture of Eprinomectin B1a and B1b showing anti-anthelintic activity

brand name

Eprinex [Veterinary](Merial).

Veterinary Drugs and Treatments

In cattle, eprinomectin is indicated for a variety gastrointestinal roundworms including adult and L4 stages of Haemonchus placei, Ostertagia ostertagi, Trichostrongylus axei and colubriformis, Cooperia oncophora/punctata/surnabada, Nematodirus helvetianus, Oesophagostomum radiatum, Bunostomum phlebotomum, and Trichuris spp. (adults only); cattle grubs; lice; mange mites; horn flies (for 7 days after treatment), and lungworms (Dictyocaulus vivaparus—for 21 days after treatment).
Topical eprinomectin may be useful for the topical treatment of ear mites (Psoroptes cuniculi) in rabbits. One small study (6 subjects) showed partial response when rabbits were dosed at 5 mg/kg topically, twice at 14 day intervals. (Ulutas, Voyvoda et al. 2005)

Toxicity evaluation

Acute oral LD₅₀ for rats: 55mg/kg

Eprinomectin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Eprinomectin manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.

Product: EPRINOMECTIN 123997-26-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 95.0%
Supply Ability: 1tons
Release date: 2024-04-26

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Eprinomectin 123997-26-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 100kg
Release date: 2021-10-21

Hebei Yanxi Chemical Co., Ltd.

Product: Eprinomectin 123997-26-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: CP2015
Supply Ability: 20tons
Release date: 2023-09-20

123997-26-2, EprinomectinRelated Search:

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EPRINOMECTIN

(4''R)-4''-(ACETYLAMINO)-4''-DEOXY-AVERMECTIN B1

Emamectin B1 Benzoate

EPRINOMECTIN VETRANAL

EprinomectinB1

Avermectin B1, 4-(acetylamino)-4-deoxy-, (4R)-

(4''r)-4''-(acetylamino)-4''-deoxy-avermectin b1solution

eprinex

eprinomectin (mixure of eprinomectin b1a and b1b minor component)

eprinomectin solution

MK 397

Acetaminoabamectin

Eprinomectin, 100 ng/ in Acetonitril , Vetranal

Eprinomection

Eprinomectin (300 mg) (COLD SHIPMENT REQUIRED)

MK-397, 4''R-epiacetylaMino-4''-deoxyaverMectin B1

EprinoMectin-d3 (Mixture of B1a and B1b)

Eprinomectin@100 μg/mL in Acetonitrile

Eprinomectin (Mixture of B1a and B1b)

acetamido abamectin

Eprinomectin (COLD SHIPMENT REQUIRED) (1237752)

Acetaminobamectin

CA13187000 Eprinomectin

Eprinomectin 100 μg/ml Acetonitrile

Eprinomectin in Acetonitrile

Phenyl Acetate Impurity 12

Eprinomectin, 10 mM in DMSO

123997-26-2

C50H75NO14C49H73NO14

C50H75NO14

C49H72NO14R

C49H73NO14C50H75NO14

Chiral Reagents

Heterocycles