Etonogestrel
- Product Name
- Etonogestrel
- CAS No.
- 54048-10-1
- Chemical Name
- Etonogestrel
- Synonyms
- Nexplanon;Implanon;org3236;CS-1364;Etonoestrel;ETONOGESTREL;3-oxodesogestrel;3-KETO DESOGESTREL;Etonogestrel Solution;Deoxyprene impurity D
- CBNumber
- CB8146610
- Molecular Formula
- C22H28O2
- Formula Weight
- 324.46
- MOL File
- 54048-10-1.mol
Etonogestrel Property
- Melting point:
- 182-184°C
- Boiling point:
- 473.1±45.0 °C(Predicted)
- alpha
- D +87.6°
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: >5mg/mL
- pka
- 13.04±0.40(Predicted)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D +80 to +95°, c = 1 (CHCl3)
- InChIKey
- GCKFUYQCUCGESZ-BPIQYHPVSA-N
- CAS DataBase Reference
- 54048-10-1(CAS DataBase Reference)
Safety
- Risk Statements
- 60-40
- WGK Germany
- 3
- RTECS
- JF8290000
- HS Code
- 2937230000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H351Suspected of causing cancer
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML0356
- Product name
- Etonogestrel
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- SML0356
- Product name
- Etonogestrel
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $463
- Updated
- 2024/03/01
- Product number
- PHR2453
- Product name
- Etonogestrel
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 200MG
- Price
- $534
- Updated
- 2024/03/01
- Product number
- 1173268
- Product name
- Desogestrel Related Compound C
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 25MG
- Price
- $1370
- Updated
- 2022/05/15
- Product number
- 21062
- Product name
- Etonogestrel
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Etonogestrel Chemical Properties,Usage,Production
Description
Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.
Chemical Properties
White Solid
Uses
A biologically active metabolite of Desogestrel.
Definition
ChEBI: Etonogestrel is a 17beta-hydroxy steroid, a 3-oxo-Delta(4) steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a female contraceptive drug.
brand name
Implanon (Organon).
General Description
Etonogestrel, 17α-13-ethyl-17hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one,3-ketodesogestrel, is the active metabolite of desogestrel. It isthe progestin component in a newer implantable contraceptive(Implanon) and in the vaginal contraceptive ring (NuvaRing).
Biochem/physiol Actions
Etonogestrel is a lipophilic molecule. Pharmacokinetics studies reveal that etonogestrel is bound to protein albumin in the blood. This remains independent of both endogenous and exogenous concentration of estradiol.
Mode of action
Etonogestrel binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression. As a result of the negative feedback mechanism, luteinizing hormone (LH) release is inhibited, which leads to an inhibition of ovulation and an alteration in the cervical mucus and endometrium.
Etonogestrel Preparation Products And Raw materials
Raw materials
Preparation Products
Etonogestrel Suppliers
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View Lastest Price from Etonogestrel manufacturers
- Product
- Etonogestrel 54048-10-1
- Price
- US $40.00-40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-22
- Product
- Etonogestrel 54048-10-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- Etonogestrel 54048-10-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 10kg/month
- Release date
- 2021-06-10