ChemicalBook > CAS DataBase List > Etonogestrel

Etonogestrel

Product Name
Etonogestrel
CAS No.
54048-10-1
Chemical Name
Etonogestrel
Synonyms
Nexplanon;Implanon;org3236;CS-1364;Etonoestrel;ETONOGESTREL;3-oxodesogestrel;3-KETO DESOGESTREL;Etonogestrel Solution;Deoxyprene impurity D
CBNumber
CB8146610
Molecular Formula
C22H28O2
Formula Weight
324.46
MOL File
54048-10-1.mol
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Etonogestrel Property

Melting point:
182-184°C
Boiling point:
473.1±45.0 °C(Predicted)
alpha 
D +87.6°
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: >5mg/mL
pka
13.04±0.40(Predicted)
form 
powder
color 
white to beige
optical activity
[α]/D +80 to +95°, c = 1 (CHCl3)
InChI
InChI=1/C22H28O2/c1-4-21-13-14(3)20-17-9-7-16(23)12-15(17)6-8-18(20)19(21)10-11-22(21,24)5-2/h2,12,17-20,24H,3-4,6-11,13H2,1H3/t17-,18-,19-,20+,21-,22-/s3
InChIKey
GCKFUYQCUCGESZ-BPIQYHPVSA-N
SMILES
C([C@]12CC(=C)[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)C#C)C |&1:1,5,7,17,19,23,r|
CAS DataBase Reference
54048-10-1(CAS DataBase Reference)
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Safety

Risk Statements 
60-40
WGK Germany 
3
RTECS 
JF8290000
HS Code 
2937230000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H351Suspected of causing cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0356
Product name
Etonogestrel
Purity
≥98% (HPLC)
Packaging
5mg
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0356
Product name
Etonogestrel
Purity
≥98% (HPLC)
Packaging
25mg
Price
$463
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2453
Product name
Etonogestrel
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
200MG
Price
$534
Updated
2024/03/01
Sigma-Aldrich
Product number
1173268
Product name
Desogestrel Related Compound C
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25MG
Price
$1370
Updated
2022/05/15
Cayman Chemical
Product number
21062
Product name
Etonogestrel
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
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Etonogestrel Chemical Properties,Usage,Production

Description

Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.

Chemical Properties

White Solid

Uses

A biologically active metabolite of Desogestrel.

Definition

ChEBI: Etonogestrel is a 17beta-hydroxy steroid, a 3-oxo-Delta(4) steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a female contraceptive drug.

brand name

Implanon (Organon).

General Description

Etonogestrel, 17α-13-ethyl-17hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one,3-ketodesogestrel, is the active metabolite of desogestrel. It isthe progestin component in a newer implantable contraceptive(Implanon) and in the vaginal contraceptive ring (NuvaRing).

Biochem/physiol Actions

Etonogestrel is a lipophilic molecule. Pharmacokinetics studies reveal that etonogestrel is bound to protein albumin in the blood. This remains independent of both endogenous and exogenous concentration of estradiol.

Mode of action

Etonogestrel binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression. As a result of the negative feedback mechanism, luteinizing hormone (LH) release is inhibited, which leads to an inhibition of ovulation and an alteration in the cervical mucus and endometrium.

Etonogestrel Preparation Products And Raw materials

Raw materials

Preparation Products

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Etonogestrel Suppliers

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View Lastest Price from Etonogestrel manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Etonogestrel 54048-10-1
Price
US $1000.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-16
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Etonogestrel 54048-10-1
Price
US $1.00/g
Min. Order
1g
Purity
≥99%
Supply Ability
10kg/month
Release date
2021-06-10
Shaanxi Dideu Medichem Co. Ltd
Product
Etonogestrel 54048-10-1
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26

54048-10-1, EtonogestrelRelated Search:

Gestrinone Trinexapac-ethyl Ethyl propiolate Ethyl acetate Altrenogest Desogestrel Gestodene CHLOROPHOSPHONAZO III Ethylparaben Ethyl acrylate Ethyl cyanoacetate Ethanol ISOXADIFEN-ETHYL Eprinomectin Ectoine Brexpiprazole Levonorgestrel Norgestrel

  • Desogestrel Related CoMpound C
  • 13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-one
  • 3-KETO DESOGESTREL
  • ETONOGESTREL
  • (17alpha)-13-ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one
  • 3-Ketodesogestrel,3-Oxodesogestrel,Org-3236,Implanon
  • (17R)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one
  • Desogestrel Related Compound C (25 mg) (3-Keto-desogestrel)
  • Etonoestrel
  • (17α)-13-Ethyl-17-hydroxy-11-Methylene-18,19-dinorpregn-4-en-20-yn-3-one
  • (17a)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one
  • Implanon
  • Deoxypregnancy impurity D
  • (17-alpha)-13-ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-on
  • 13-ethyl-11-methylene-18,19-dinor-17-alpha-pregn-4-en-20-yn-3-one
  • 17-ethinyl-17-beta-hydroxy-18-methyl-11-methylene-4-estren-3-one
  • 19-dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-11-methylene-1(17-alpha
  • 3-oxodesogestrel
  • org3236
  • Etonogestrel-d6（Desogestrel EP Impurity D-d6）
  • Desogestrel EP Impurity D-d6
  • IMPLANON;NEXPLANON;3-OXODESOGESTREL;3-KETO-DESOGESTREL
  • Nexplanon
  • CS-1364
  • Desogestrel Impurity 4(Desogestrel EP Impurity D)
  • 3-Ketodesogestrel (Etonogestrel)
  • Etonogestrel Solution
  • desogestrel impurity D
  • Deoxyprene impurity D
  • 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17α)-
  • Etonogestrel USP/EP/BP
  • ETONOGESTREL 54048-10-1
  • Etonogestrel D6Q: What is Etonogestrel D6 Q: What is the CAS Number of Etonogestrel D6 Q: What is the storage condition of Etonogestrel D6
  • Etonogestrel D7Q: What is Etonogestrel D7 Q: What is the CAS Number of Etonogestrel D7 Q: What is the storage condition of Etonogestrel D7
  • EtonogestrelQ: What is Etonogestrel Q: What is the CAS Number of Etonogestrel Q: What is the storage condition of Etonogestrel Q: What are the applications of Etonogestrel
  • Desogestrel Related Compound C (3-Ketodesogestrel) (1173268)
  • Etonogestrel (1268783)
  • 11-Dihydrocarbamazepine
  • Desogestrel USP Related Compound C
  • Desogestrel Related Compound C (3-Ketodesogestrel)
  • Etonogestrel (Desogestrel EP Impurity D, Desogestrel USP Related Compound C, 3-Ketodesogestrel)
  • Desogestrel Related Compound C (25 mg) (13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol-3-one)
  • 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17α)-
  • 54048-10-1
  • 54058-10-1
  • C22H28O2
  • API
  • Inhibitors
  • Hormone Drugs
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Steroids